YILDIRAY BAŞBUĞAN, NAZMİ YÜKSEK, NURİ ALTUĞ

Significance of homocysteine and cardiac markers in cattle with hypocalcemia

This study aimed to determine the levels of homocysteine and cardiac markers in cows with hypocalcemia. This research was conducted with a total of 20 cows, including 10 with hypocalcemia and 10 healthy controls. Hypocalcemia was diagnosed by determining low blood calcium (Ca) levels, and a standard hypocalcemia treatment was initiated in those cows with the disease. Blood samples were taken before the treatment and again 12 h after the treatment, and there was no significant difference in the homocysteine levels between the groups. Ca, ionized calcium (Ica), magnesium (Mg), and phosphorus (P) levels were lower, while cardiac troponin I (cTnI), parathormone (PTH), creatine kinase (CK), and creatine kinase-MB (CK-MB) levels were higher before treatment as compared with the control group. Increases in the Ca, Mg, Ica, and P levels, and a decrease in the PTH levels were detected after treatment when compared with those levels before treatment. The CK, CK-MB, and Mg levels also increased, while the Ica level decreased in the after-treatment group as compared with the control group. Therefore, the cTnI, CK, and CK-MB in cows with hypocalcemia were determined to be important diagnostically, but insignificant for prognosis. Homocysteine was not important for either diagnosis or prognosis.

Anahtar Kelimeler:

Hypocalcemia, homocysteine, cardiac biomarkers, troponin I

Significance of homocysteine and cardiac markers in cattle with hypocalcemia

Keywords:

Hypocalcemia, homocysteine, cardiac biomarkers, troponin I,

PDF

___

Çitil M. Diagnose of clinic and subclinic hypocalcemia. Review. Türkiye Klinikleri J Vet Sci 2011; 2: 110–117 (article in Turkish with an abstract in English).
Ok M. Treatment of milk fever and causes of failure of treatment. Review. Türkiye Klinikleri J Vet Sci 2011; 2: 118–122 (article in Turkish with an abstract in English).
Gül Y. Geviş Getiren Hayvanların İç Hastalıkları (Sığır, Koyun- Keçi). 3rd ed. Malatya, Turkey: Medipres; 2012 (in Turkish).
Alaçam E. Transition period and it’s important problems in dairy cows. Review. Turkiye Klinikleri J Vet Sci 2011; 2: 85–95 (article in Turkish with an abstract in English).
Harris B, Shearer JK. Metabolic Diseases of Dairy Cattle– Milk Fever. Fact Sheet DS 74 of the Dairy Production Guide. Gainesville, FL, USA: University of Florida; 1992.
Radostits OM, Gay CC, Hinchcliff KW, Constable PD. Veterinary Medicine: A Textbook of the Diseases of Cattle, Sheep, Goats, Pigs and Horses. 10thEd. Philadelphia, PA, USA: Saunders; 2007.
Başoğlu A, Sevinç M. Metabolik ve Endokrin Hastalıklar. Konya, Turkey: Pozitif Matbaacılık; 2004.
Kaneko JJ. Clinical Biochemistry of Domestic Animals, 5th ed. San Diego, CA, USA: Academic Press; 1997.
Mano T, Kamiya H, Kawakita S, Imamura Y, Suzuki A, Tani N, Hasegawa, H. A case of primary hypoparathyroidism complicated by heart failure. Jpn J Med 1991; 30: 464–467.
Gauthier GM, Keevil JG, McBride PE. The association of homocysteine and coronary artery disease. Clin Cardiol 2003; 26: 563–568.
Ciaccio M, Bivona G, Bellia C. Therapeutical approach to plasma homocysteine and cardiovascular risk reduction. Ther Clin Risk Manag 2008; 4: 219–224.
Gunes V, Atalan G, Citil M, Erdogan, HM. Use of cardiac troponin kits for the qualitative determination of myocardial cell damage due to traumatic reticuloperitonitis in cattle. Vet Rec 2008; 162: 514–517.
Gunes V, Erdogan HM, Citil M, Ozcan K. Assay of cardiac troponins in the diagnosis of myocardial degeneration due to foot and mouth disease in a calf. Vet Rec 2005; 156: 714–715.
Guyton AC, Hall JE. Tıbbi Fizyoloji, Türkçe. 10th ed. İstanbul, Turkey: Tavaslı Matbaacılık; 2001 (in Turkish).
Başbuğan Y, Ağaoğlu ZT, Yüksek N. An investigation on serum troponin concentration in healthy ruminants. Kafkas Univ Vet Fak Derg 2010; 16: 641–645.
Oetzel GR. Minimizing hypocalcemia during early lactation. In: Tri-State Dairy Nutrition Conference. Fort Wayne, IN, USA: Ohio State University 2013. pp. 23–32.
Salmanoğlu R, Salmanoğlu B. Puerperal hipokalsemili ineklerde kan kalsiyum düzeyleri ve klinik gözlemler. Ankara Üniv Vet Fak Derg 1998; 45: 151–157 (in Turkish).
Mulligan F, O’Grady L, Rice D, Doherty M. Production diseases of the transition cow: milk fever and subclinical hypocalcemia. Irish Vet J 2006; 59: 697–702.
Can MF. A socio-economic analysis of small ruminant breeders’ membership relations and organizational effectiveness. Ankara Üniv Vet Fak Derg 2014; 61: 119–124.
Can, MF, Altuğ, N. Socioeconomic implications of biosecurity practices in small-scale dairy farms. Vet Quart 2014; 34: 67–73.
Dabak M. Etiopathogenesis of calcium and phosphorus metabolism disorders. Review. Türkiye Klinikleri J Vet Sci 2011; 2: 102–109 (article in Turkish with an abstract in English).
Turgut K. Veteriner Klinik Laboratuvar Teşhis. Konya, Turkey: Bahçıvanlar Basım Sanayi; 2000.
Jackson PGG, Cockcroft PD. Clinical Examination of Farm Animals. Oxford, UK: Blackwell Science; 2002.
Goff JP, Liesegang A, Horst RL. Diet-induced pseudo hypoparathyroidism: a hypocalcemia and milk fever risk factor. J Dairy Sci 2013; 97: 1520–1528.
Sevinç M, Aslan V. The relationship between parturient paresis and fat cow syndrome in dairy cows. Turk J Vet Anim Sci 1998; 22: 23–28 (in Turkish with an abstract in English).
Zebeli Q, Beitz DC, Bradford BJ, Dunn SM, Ametaj BN. Peripartal alterations of calcitonin gene-related peptide and minerals in dairy cows affected by milk fever. Vet Clin Pathol 2013; 42: 70–77.
Ağaoğlu ZT, Yüksek N, Başbuğan Y. Magnesium metabolism and its disorders. Review. Türkiye Klinikleri J Vet Sci 2011; 2: 162–167 (article in Turkish with an abstract in English).
Şen İ, Güzelbekteş H, Coşkun A. Postparturient hemoglobinuria in dairy cattle. Review. Türkiye Kilinikleri J Vet Sci 2011; 2: 158–161 (article in Turkish with an abstract in English).
Leonardi F, Passeri B, Fusari A, De Razza P, Beghi C, Lorusso R, Corradi A, Botti P. Cardiac troponin I (cTn I) concentration in an ovine model of myocardial ischemia. Res Vet Sci 2008; 85: 141–144.