Valentina URUMOVA, Ivan FASULKOV, Nasko VASILEV, Teodora MIRCHEVA, Manol KARADAEV

Determination of plasma fbrinogen and haptoglobin, hematological and blood biochemical changes in Bulgarian local goats with experimentally induced Staphylococcus aureus mastitis

The aim of the present study was to assess changes in acute phase proteins fbrinogen and haptoglobin, as well as hematological,blood biochemical, and microbiological alterations in local Bulgarian goats with experimentally induced Staphylococcus aureus mastitis.The experiments were conducted with 6 clinically healthy local Bulgarian goats, 2 to 6 years of age, weighing 46 57 kg. Te experimentalinfection was done with a stationary phase culture of a feld Staphylococcus aureus strain isolated from a cow with clinical mastitis.Blood haptoglobin in goats was considerably higher (Р < 0.05) as early as 8 h afer the pathogen s inoculation. The most signifcantdiferences from baseline values occurred 24 and 48 h (Р < 0.01) afer infection. Plasma fbrinogen increased signifcantly (Р < 0.05)8 h afer infection and reached the highest mean concentration (9.12 g/L) by 72 h. Leukocytosis was established as early as 4 h aferthe experimental infection when leukocyte counts were signifcantly higher than baseline (Р < 0.001). Te analysis of results indicatesthat in experimentally induced Staphylococcus aureus mastitis, signifcantly higher (P < 0.05) levels of the leukocyte, fbrinogen, andhaptoglobin are established as early as 8 h afer the infection.

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