The aim of this study was to evaluate milk glutathione peroxidase (GPx) and superoxide dismutase (SOD) levels in Damascus goats with subclinical mastitis. According to the somatic cell counts (SCCs), 193 Damascus goats included in the study were divided into healthy (n = 75; SCC 0.05). In summary, a significant increase in GPx and decrease in SOD levels, respectively, were determined in goat milk samples with subclinical mastitis, and these changing trends were correlated with milk SCCs. However, age, parity, and number of offspring were not associated with these changing patterns.