Postoperatif atriyal fi brilasyon, infl amasyon ve oksidatif stress

Postoperatif atriyal fi brilasyon kardiyak cerrahinin en sık görülen komplikasyonudur ve artmış komplikasyon riski ile ilişkilidir. Son zamanlarda yapılan araştırmalar infl amasyon ve oksidatif stresin atriyal fi brilasyon patofi zyolojisinde anahtar rol alabileceğini göstermiştir. Statinler, kortikosteroidler, N-asetil sistein, vitamin C ve balık yağı gibi antiinfl amatuar ve antioksidan ajanların postoperatif atriyal fi brilasyon sıklığını üzerine etkisini araştıran çalışmalarda ümit verici bulgular elde edilmesine rağmen; kesin birşey söylemek için farklı doz rejimlerinin kullanıldığı büyük randomize kontrollü çalışmalara ihtiyaç vardır.

Anahtar Kelimeler:

Koroner arter baypass cerrahisi, atriyal fi brilasyon, infl amasyon, oksidatif stress

Postoperative atrial fibrillation, oxidative stress, and inflammation

Postoperative atrial fibrillation is the most common complication of cardiac surgery. It is associated with increased complication rates. Recent trials have suggested that inflammation and oxidative stress have key roles in the pathophysiology of atrial fibrillation. Current evidence evaluating the use of antiinflammatory and antioxidant agents, including statins, corticosteroids, N-acetylcysteine, vitamin C, and fish oil, to prevent postoperative atrial fibrillation is promising. However, larger randomized, controlled trials comparing different dose regimens are needed.

Keywords:

atrial fibrillation, inflammation, oxidative stress, Coronary artery bypass graft s,

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