Parental obesity compared with serum leptin and serum leptin receptor levels among abese adults in the Gaza Strip
Aims: To investigate whether parental obesity influences serum leptin hormone and soluble leptin receptor (Ob-Re) concentrations among obese adults in the Gaza Strip. Materials and methods: A case-control design was used. Sample used was convenient and obtained from 2 largest obesity clinics in the Gaza Strip. It consisted of 83 overweight and obese adults without history of other diseases (case group). Control group consisted of 83 ideal weight adults who were selectively chosen from the same clinics. Self reported structured interviews and serum blood samples were obtained from both groups. Human leptin competitive ELISA kits were used for determination of leptin and Ob-Re concentrations in the blood serum. SPSS system was used to analyze the data. Results: About 69% of the case group was found to have paternal and/or maternal obesity. Moreover, the mean of serum leptin hormone levels for the obese adults with history of obese parents was significantly higher than obese adults without history of obese parents (P = 0.02). No significant correlation was observed between parental obesity and Ob-Re levels among the case group (P = 0.88). Conclusions: Parental obesity plays an important role in obesity and serum leptin level during adulthood.
Parental obesity compared with serum leptin and serum leptin receptor levels among abese adults in the Gaza Strip
Aims: To investigate whether parental obesity influences serum leptin hormone and soluble leptin receptor (Ob-Re) concentrations among obese adults in the Gaza Strip. Materials and methods: A case-control design was used. Sample used was convenient and obtained from 2 largest obesity clinics in the Gaza Strip. It consisted of 83 overweight and obese adults without history of other diseases (case group). Control group consisted of 83 ideal weight adults who were selectively chosen from the same clinics. Self reported structured interviews and serum blood samples were obtained from both groups. Human leptin competitive ELISA kits were used for determination of leptin and Ob-Re concentrations in the blood serum. SPSS system was used to analyze the data. Results: About 69% of the case group was found to have paternal and/or maternal obesity. Moreover, the mean of serum leptin hormone levels for the obese adults with history of obese parents was significantly higher than obese adults without history of obese parents (P = 0.02). No significant correlation was observed between parental obesity and Ob-Re levels among the case group (P = 0.88). Conclusions: Parental obesity plays an important role in obesity and serum leptin level during adulthood.
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- Van-Dielen FMH, Van’t-Veer C, Buurman WA, Greve WM. Leptin and soluble leptin receptor levels in obese and weight losing individuals. J Clin Endocrinol Metab 2002; 87: 1708-1716.
- Laimer M, Ebenbichler CF, Kaser S, Sandhofer A, Weiss H, Nehoda H, et al. Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin. Obes Res 2002; 10: 597-601.
- Friedman JM, Halaas JL, Leptin and the regulation of body weight in mammals. Nature 1998; 395: 763-770.
- Dudeja V, Misra A, Pandey RM, Devina G, Kumar G, Vikram N K. BMI does not accurately predict overweight in Asia Indians in northern India. British J. Nutrition 2001; 86(1): 105-112.
- Nutrition Department, Directorate General of Primary Health Care and Public Health. The State of Nutrition West Bank and Gaza Strip: A comprehensive review of nutrition situation of West Bank and Gaza strip. UNICEF, WHO, and Palestinian National authority, MOH, Palestine; 2004.
- National Heart, Lung and Blood Institute, Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. The evidence report. Obes Res 1998; 6: 51S–209S.
- Kopelman PG. Obesity as a medical problem. Nature 2000; 404: 635-643.
- Kantachuvessiri A. Obesity in Thailand. J Med Assoc Thai 2005; 88: 554-562.
- Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. Predicting obesity in young adulthood from childhood and parental obesity. N Eng Med 1997; 337: 869-873.
- The National Academies press. Exploring a vision: Integrating knowledge for food and health; 2005
- WHO. The World Health Report. Life in the 21stcentury: A vision for all. Geneva; 1998.
- Warsy AS. El-Hazmi MAF. Diabetes meletus, hypertension and obesity- Common multifactorial disorders in Saudis. EMHJ 1999; 5/6: 1236-1242.
- Abdul-Rahim HF, Abu-Rmeileh NME, Husseini A, Holmboe- Ottesen G, Jervell J, Bjertness E. Obesity and selected co- morbidities in an urban Palestinian population. International Journal of obesity 2001; 25: 1736-1740.
- Zabut BM, Holi NH, El-Jeesh YI . Leptin and leptin receptor among obese Adults in the Gaza Strip. The Islamic University Journal 2007; 15: 127-140.
- Diagnostic System Laboratories, Inc. Texas, USA. Active Human Leptin ELISA, DSL-10-23100.
- Diagnostic System Laboratories, Inc. Texas, USA. Active Human Leptin Soluble Receptor ELISA, DSL-10-23200.
- Willms JD, Tremblay MS, Katzmarzyk PT. Geographic and demographic variation in the prevalence of overweight Canadian children. Obes Res 2003; 11: 668-673.
- Neiman P. Childhood Obesity. Retrieved on September 25th, 2004 from the World Wide Web: http://ditk-kids.com/articles/ childhood_obesity.htm.
- Frisancho AR. Prenatal compared with parental origins of adolescent fatness. Am J. clin. Nutr 2000; 72: 1186-1190.
- Whitaker RC, wright JA, Pepe MS, Seidel KD, Dietz WH. Predicting obesity in young adulthood from childhood and parental obesity. N Eng J. Med 2000; 337: 869-873.
- Tarquini B, Tarquini R, Perfetto F, Cornelissen G, Halberg F. Genetic and environmental Influences on human leptin concentration. Pediatrics 1999; 103: 998-1006.
- Tessitore L, Vizio B, Pesola D, Cecchini F, Mussa A, Argiles JM, et al. Expression and circulating levels of leptin increase in both gynaecological and breast cancer patients. Int J Oncol 2004; 24: 1529-1535.
- Considine RV, Sinha Mk, Heiman ML, Kriangiunas A, Stephens TW, Nyce MR, et al. Serum immunoreactive-leptin concentration in normal weight and obese humans. N Eng J Med 1996; 331: 292-295.
- Popruk S, Tungtrongchitr R, Pongpaew P, Phourat B, Tungtrongchitr A, Tribunyatkul S, et al. Relationship between soluble leptin receptor, leptin, lipid profiles and anthropometric parameters in overweight and obese Thai subjects. J Med Asso Thai, 2005; 88: 220-227.