İltemir Candan DUVAN, Bülent BERKER, Hakan ŞATIROĞLU, Nilgün Öztürk TURHAN, Kaan AYDOZ, Ömer BAYRAK

Comparison of semen parameters between pregnant and nonpregnant couples with male factor infertility during intrauterine insemination

Amaç: Erkek faktörüne bağlı infertilitesi bulunan, gebeliği olan ve olmayan çiftlerin semen parametrelerinin intrauterin inseminasyon İUİ sırasında karşılaştırmak. Materyal ve metodlar: Çalışma, Ocak 2005 ile Aralık 2006 arasında erkek infertilite tanısıyla kliniğimizde uygulanan 156 İUİ siklusu içermektedir. İUİ siklusları, Grup 1, gebe (24 siklus) ve Grup 2, gebe olmayan (132 siklus) şeklinde iki gruba bölünmüştür.Bulgular: Her iki grupta da, ne başlangıçta ne de işlem görmüş sperm örneklerindeki progresif motilite istatistiksel olarak anlamlı idi (P > 0,05). Gruplar arasında başlangıç semen parametreleri karşılaştırıldığında sperm konsantrasyonu ve total sperm sayısı (TSS) belirgin olarak anlamlıydı (P = 0,03, P = 0,04). Örneklere işlem uygulandıktan sonra gebe olan ve olmayan sikluslarda sperm sayısı ve insemine motil sperm sayılarında belirgin olarak bir farklılık bulundu (P = 0,03, P = 0,03). 10 × 10 6 dan fazla TSS olduğunda % 18’ lik bir gebelik oranı sağlanmışken, 10 × 10 6 dan daha az TSS’de bu oran % 10 dır, istatistiksel olarak bir fark görülmemiştir (P > 0,05). Sonuçlar: Erkek faktörlü infertilitede, TSS ve IMS’ye ek olarak örneklerdeki sperm konsantrasyonu da İUİ’ ye bağlı gebelik sonuçlarını etkileyebilir.

Erkek faktör infertilitesine bağlı intrauterin inseminasyon yapılan çiftlerde semen parametrelerinin gebe kalan ve kalmayanlarda karşılaştırılması

Aim: To compare the semen parameters between pregnant and nonpregnant couples with male factor infertility during intrauterine insemination (IUI). Materials and Methods: The study included a total of 156 IUI cycles performed in our center from January 2005 to December 2006 with the indication of male infertility. IUI cycles were divided into 2 groups: group 1 pregnancy (24 cycles) and group 2 (132 cycles) nonpregnancy cycles.Results: In both groups, progressive motility of neither initial nor processed sperm specimens was significantly different (P > 0.05). When comparisons of semen parameters in groups were performed in the initial specimen, sperm concentration and total motile sperm count (TMC) were significantly different between the groups (P = 0.03, P = 0.04, respectively). After processing specimens a definite significant difference was found in sperm concentration and inseminated motile sperm count (IMC) between pregnancy and nonpregnancy cycles (P = 0.03, P = 0.03, respectively). Although TMC > 10 × 10 6 provided a pregnancy rate (PR) of 18% compared with TMC < 10 × 10 6 (PR: 10%), no significant differences were detected (P > 0.05).Conclusions: In addition to the initial TMC and IMC, sperm concentration in both initial and processed specimens may influence IUI-related pregnancy in male factor infertility.

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