Oral mucosal lesions: a retrospective review of one institution’s 13-year experience

To investigate the relative frequency of biopsied nonneoplastic oral mucosal lesions in Ankara, Turkey. Materials and methods: Biopsy records of a single center from 2000-2012 were retrospectively collected. Diagnosis was recorded and evaluated with respect to patient demographics (age, sex) and location of the lesion. Results: Of 11,980 biopsies, 1732 (14.5%) were mucosal nonneoplastic lesions. Hyperplastic lesions (n = 1000, 57.7%) with fibroepithelial hyperplasia in 30.9% of patients were the most common type of oral nonneoplastic lesions. The mean age of patients differed with respect to type of mucosal lesion, tending to be lower in patients with reactive lesions. Dermatoses showed a female predominance. Conclusion: Our findings revealed that hyperplastic lesions were the most common among nonneoplastic oral mucosa lesions. Geographic and ethnic differences of patients with various types of oral mucosal lesions require further investigation.

Oral mucosal lesions: a retrospective review of one institution’s 13-year experience

To investigate the relative frequency of biopsied nonneoplastic oral mucosal lesions in Ankara, Turkey. Materials and methods: Biopsy records of a single center from 2000-2012 were retrospectively collected. Diagnosis was recorded and evaluated with respect to patient demographics (age, sex) and location of the lesion. Results: Of 11,980 biopsies, 1732 (14.5%) were mucosal nonneoplastic lesions. Hyperplastic lesions (n = 1000, 57.7%) with fibroepithelial hyperplasia in 30.9% of patients were the most common type of oral nonneoplastic lesions. The mean age of patients differed with respect to type of mucosal lesion, tending to be lower in patients with reactive lesions. Dermatoses showed a female predominance. Conclusion: Our findings revealed that hyperplastic lesions were the most common among nonneoplastic oral mucosa lesions. Geographic and ethnic differences of patients with various types of oral mucosal lesions require further investigation.

___

  • Gultelkin SE, Tokman B, Turkseven MR. A review of paediatric oral biopsies in Turkey. Int Dent J 2003; 53: 26–32.
  • Adisa AO, Adeyemi BF, Oluwasola AO, Kolude B, Akang EE, Lawoyin JO. Clinico-pathological profile of head and neck malignancies at University College Hospital, Ibadan, Nigeria. Head Face Med 2011; 7: 9.
  • Jones AV, Franklin CD. An analysis of oral and maxillofacial pathology found in adults over a 30-year period. J Oral Pathol Med 2006; 35: 392–401. 4. Endo H, Rees TD, Matsue M, Kuyama K, Nakadai M, Yamamoto H. Early detection and successful management of oral pemphigus vulgaris: a case report. J Periodontol 2005; 76: 154–160.
  • Kumaraswamy KL, Vidhya M, Rao PK, Mukunda A. Oral biopsy: oral pathologist’s perspective. J Cancer Res Ther 2012; 8: 192–198.
  • Zhang W, Chen Y, An Z, Geng N, Bao D. Reactive gingival lesions: a retrospective study of 2,439 cases. Quintessence Int 2007; 38: 103–110.
  • Prabhu SR, Wilson DF. Human papillomavirus and oral disease - emerging evidence: a review. Aust Dent J 2013; 58: 2–10; quiz 125.
  • Rubaci AH, Kazancioglu HO, Olgac V, Ak G. The roles of matrix metalloproteinases-2, -7, -10 and tissue inhibitor of metalloproteinase-1 in the pathogenesis of oral lichen planus. J Oral Pathol Med 2012; 41: 689–696.
  • Kaplan I, Ventura-Sharabi Y, Gal G, Calderon S, Anavi Y. The dynamics of oral lichen planus: a retrospective clinicopathological study. Head Neck Pathol 2012; 6: 178–183.
  • Gondak RO, da Silva-Jorge R, Jorge J, Lopes MA, Vargas PA. Oral pigmented lesions: Clinicopathologic features and review of the literature. Med Oral Patol Oral Cir Bucal 2012; 17: e919– 924.
  • Sixto-Requeijo R, Diniz-Freitas M, Torreira-Lorenzo JC, Garcia-Garcia A, Gandara-Rey JM. An analysis of oral biopsies extracted from 1995 to 2009, in an oral medicine and surgery unit in Galicia (Spain). Med Oral Patol Oral Cir Bucal 2012; 17: e16–22.
  • Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. St. Louis, MO, USA: Saunders; 2009.
  • Mumcu G, Cimilli H, Sur H, Hayran O, Atalay T. Prevalence and distribution of oral lesions: a cross-sectional study in Turkey. Oral Dis 2005; 11: 81–87.
  • Shamim T, Varghese VI, Shameena PM, Sudha S. A retrospective analysis of gingival biopsied lesions in South Indian population: 2001-2006. Med Oral Patol Oral Cir Bucal 2008; 13: E414–418.
  • Rossi EP, Hirsch SA. A survey of 4,793 oral lesions with emphasis on neoplasia and premalignancy. J Am Dent Assoc 1977; 94: 883–886.
  • Bhaskar SN. Oral pathology in the dental office: survey of 20,575 biopsy specimens. J Am Dent Assoc 1968; 76: 761–766.
  • Gumru B. A retrospective study of 370 patients with oral lichen planus in Turkey. Med Oral Patol Oral Cir Bucal 2013; 18: e427–432.
  • Alli N, Gur G, Yalcin B, Hayran M. Patient characteristics in Behçet disease: a retrospective analysis of 213 Turkish patients during 2001-4. Am J Clin Dermatol 2009; 10: 411–418.
  • Weir JC, Davenport WD, Skinner RL. A diagnostic and epidemiologic survey of 15,783 oral lesions. J Am Dent Assoc 1987; 115: 439–442.
  • Greer RO Jr. Surgical oral pathology at the University of Colorado school of dentistry: a survey of 400 cases. J Colo Dent Assoc 1976; 54: 13–16.
  • Tay AB. A 5-year survey of oral biopsies in an oral surgical unit in Singapore: 1993-1997. Ann Acad Med Singapore 1999; 28: 665–671.
  • Buchner A, Shnaiderman-Shapiro A, Vered M. Relative frequency of localized reactive hyperplastic lesions of the gingiva: a retrospective study of 1675 cases from Israel. J Oral Pathol Med 2010; 39: 631–638.
  • Bodner L, Peist M, Gatot A, Fliss DM. Growth potential of peripheral giant cell granuloma. Oral Surg Oral Medicine Oral Pathol Oral Radiol Endod 1997; 83: 548–551.
  • Flaitz CM. Peripheral giant cell granuloma: a potentially aggressive lesion in children. Pediatr Dent 2000; 22: 232–233.
  • Gondivkar SM, Gadbail A, Chole R. Oral pregnancy tumor. Contemp Clin Dent 2010; 1: 190–192.
  • Radu O, Pantanowitz L. Kaposi sarcoma. Arch Pathol Lab Med 2013; 137: 289–294.
  • Yildirim B, Senguven B, Demir C. Prevalence of herpes simplex, Epstein Barr and human papilloma viruses in oral lichen planus. Med Oral Patol Oral Cir Bucal 2011; 16: e170– 174.
  • Au J, Patel D, Campbell JH. Oral lichen planus. Oral Maxillofac Surg Clin North Am 2013; 25: 93–100, vii.
  • Georgakopoulou EA, Achtari MD, Achtaris M, Foukas PG, Kotsinas A. Oral lichen planus as a preneoplastic inflammatory model. J Biomed Biotech 2012; 2012: 759626.
  • Robinson JC, Lozada-Nur F, Frieden I. Oral pemphigus vulgaris: a review of the literature and a report on the management of 12 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 84: 349–355.
  • Zarei MR, Chamani G, Amanpoor S. Reactive hyperplasia of the oral cavity in Kerman province, Iran: a review of 172 cases. Br J Oral Maxillofac Surg 2007; 45: 288–292.
  • Mollaoglu N. Oral lichen planus: a review. Br J Oral Maxillofac Surg 2000; 38: 370–377.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Investigation of TNF-alpha gene (G308A) and GSTP1 gene (Ile105Val) polymorphisms in Turkish patients with retinopathy of prematurity

Mehmet TÜRE, Meral YILDIZ, Mutlu KARKUCAK, Emine Tuna GÜLTEN, Deniz SIĞIRLI, Ahmet Tuncer ÖZMEN, Tahsin YAKUT

Is there any impact of PET/CT on radiotherapy planning in rectal cancer patients undergoing preoperative IMRT?

Diclehan KILIÇ, Serap ÇATLI, Şükran ÜLGER, Lütfiye Özlem KAPUCU

Beneficial effects of melatonin and BQ-123 on the rat testis damage caused by cigarette smoke

Hüseyin ASLAN, Hakan KESİCİ, Zafer İsmail KARACA, Birsen ÖZYURT, Ufuk TAŞ, Fatih EKİCİ, Hasan ERDOĞAN, Fikret GEVREK, Sevil ÇAYLI

Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence

Yong LI, Lizhou SUN, Denmei ZHAO, Jun OUYANG, Mei XIANG

Ebola viral disease: What should be done to combat the epidemic in 2014?

Aliye BAŞTUĞ, Hürrem BODUR

Is there an association between histopathological changes in the lower ureter and renal functions? Evaluation of patients who underwent ureteroneocystostomy for ureterovesical obstruction or vesicoureteral reflux

Müjdem Nur AZILI, Doğuş GÜNEY, Ayper KAÇAR, Hüseyin Tuğrul TİRYAKİ

Evaluation of autoinflammatory disease genes in nasal polyposis*

Mehmet Ali ÇETİN, Hacı Hüseyin DERE, Sibel ÖZDAŞ, Sabri KÖSEOĞLU, Serdar ENSARİ, Aykut İKİNCİOĞULLARI, Kürşat Murat ÖZCAN, Talih ÖZDAŞ

Polymorphism characteristics of HIV-1 gp120 and 5 hypervariable regions

Neng YAO, Chunxia ZHANG, Qi LIU, Jun LIU, Chiyu ZHANG

Gastrointestinal system lesions in children due to the ingestion of alkali and acid corrosive substances

Kaan DEMİRÖREN, Halil KOCAMAZ, Yaşar DOĞAN

The effect of extracorporeal shock wave lithotripsy on distribution of interstitial cells of Cajal in rabbit renal pelvis and proximal ureter

Özlem BOYBEYİ, Mine Fedakar ŞENYÜCEL, Ebru Şebnem AYVA, Tutku SOYER, Mustafa Kemal ASLAN