Assessment of nasal mucociliary clearance in anesthetists

To assess mucociliary clearance in anesthetists who were exposed to waste anesthetic gases occupationally. Materials and methods: The first group consisted of 30 anesthetists who had been working at least 2 years. The control group of 30 subjects was selected from hospital staff with no history of occupational exposure to waste anesthetic gases. Mucociliary clearance time was assessed by measuring the saccharine nasal transit time (SNTT). Results: Thirty-six women and 24 men aged between 25 and 60 years were enrolled in the study. There were no differences between the anesthetist and control groups in terms of age, sex, height, or weight. The median SNTT for the anesthetists (10 min) was longer than that for the control group (8.3 min). The difference was significant (P = 0.025). In addition, there was a significant correlation between the SNTT and the working time (P = 0.02). Furthermore, anesthetists who had worked for 4 years or more had prolonged SNTT compared to those who had worked less than 4 years (P < 0.001). Conclusion: The present study demonstrated the impairment of mucociliary clearance in anesthetists. Increasing impairment with increasing working time was also detected.

Assessment of nasal mucociliary clearance in anesthetists

To assess mucociliary clearance in anesthetists who were exposed to waste anesthetic gases occupationally. Materials and methods: The first group consisted of 30 anesthetists who had been working at least 2 years. The control group of 30 subjects was selected from hospital staff with no history of occupational exposure to waste anesthetic gases. Mucociliary clearance time was assessed by measuring the saccharine nasal transit time (SNTT). Results: Thirty-six women and 24 men aged between 25 and 60 years were enrolled in the study. There were no differences between the anesthetist and control groups in terms of age, sex, height, or weight. The median SNTT for the anesthetists (10 min) was longer than that for the control group (8.3 min). The difference was significant (P = 0.025). In addition, there was a significant correlation between the SNTT and the working time (P = 0.02). Furthermore, anesthetists who had worked for 4 years or more had prolonged SNTT compared to those who had worked less than 4 years (P < 0.001). Conclusion: The present study demonstrated the impairment of mucociliary clearance in anesthetists. Increasing impairment with increasing working time was also detected.

___

  • Henderson KA, Matthews IP. An environmental survey of compliance with Occupational Exposure Standards (OES) for anaesthetic gases. Anaesthesia 1999; 54: 941–947.
  • Turkan H, Aydin A, Sayal A. Effect of volatile anesthetics on oxidative stress due to occupational exposure. World J Surg. 2005; 29: 540–542.
  • Guirguis SS, Pelmear PL, Roy ML, Wong L. Health effects associated with exposure to anaesthetic gases in Ontario hospital personnel. Br J Ind Med 1990; 47: 490–497. 8. Corbo GM, Foresi A, Bonfitto P, Mugnano A, Agabiti N, Cole PJ. Measurement of nasal mucociliary clearance. Arch Dis Child 1989; 64: 546–550.
  • Cinar F, Beder L. Nasal mucociliary clearance in coal mine workers. Otolaryngol Head Neck Surg 2004; 130: 767–769.
  • Lale AM, Mason JD, Jones NS. Mucociliary transport and its assessment: a review. Clin Otolaryngol Allied Sci 1998; 23: 388–396.
  • Wilkes AR, Raj N, Hall JE. Adverse airway events during brief nasal inhalations of volatile anaesthetics: the effect of humidity and repeated exposure on incidence in volunteers preselected by response to desflurane. Anaesthesia 2003; 58: 207–216.
  • Ledowski T, Paech MJ, Patel B, Schug SA. Bronchial mucus transport velocity in patients receiving propofol and remifentanil versus sevoflurane and remifentanil anesthesia. Anesth Analg 2006; 102: 1427–1430.
  • Kesimci E, Bercin S, Kutluhan A, Ural A, Yamanturk B, Kanbak O. Volatile anesthetics and mucociliary clearance. Minerva Anesthesiol 2008; 74: 107–111.
  • Konrad F, Marx T, Schraag M, Kilian J. Combination anesthesia and bronchial tranport velocity. Effects of anesthesia with isoflurane, fentanyl, vecuronium and oxygen-nitrous oxide breathing on bronchial mucus transport (in German). Anaesthetist 1997; 46: 403–407.
  • Singh M, Chandra M, Gupta SC, Sharma D. Role of measurement of nasal mucociliary clearance by saccharine test as a yard stick of success of functional endoscopic sinus surgery. Indian J Otolaryngol Head Neck Surg 2010; 62: 289– 295.
  • Cervin A, Lindsberg S. Changes in mucociliary activity may be used to investigate the airway-irritating potency of volatile anaesthetics. Br J Anaesth 1998; 80: 475–480.
  • Raphael JH, Strupish J, Selwyn DA, Hann HC, Langton JA. Recovery of respiratory ciliary function after depression by inhalation anaesthetic agents: an in vitro study using nasal turbinate explants. Br J Anaesth 1996; 76: 854–859.
  • Capellier G, Zhang Z, Maheu MF, Pointet H, Racadot E, Kantelip B, Regnard J, Barale F. Nasal mucosa inflammation induced by oxygen administration in humans. Acta Anaesthesiol Scand 1997; 41: 1011–1016.
  • Chalon J, Loew DA, Malebranche J. Effects of dry anesthetic gases on tracheobronchial ciliated epithelium. Anesthesiology 1972; 37: 338–343.
  • Sackner MA, Landa J, Greenelch N, Robinson MJ. Pathogenesis and prevention of tracheobronchial damage with suction procedures. Chest 1973; 64: 284–290.
  • Keller C, Brimacombe J. Bronchial mucus transport velocity in paralyzed anesthetized patients: a comparison of the laryngeal mask airway and cuffed tracheal tube. Anesth Analg 1998; 86: 1280–1282.
  • Raphael JH, Selwyn DA, Mottram SD, Langton JA, O’Callaghan C. Effects of 3 MAC of halothane, enflurane and isoflurane on cilia beat frequency of human nasal epithelium in vitro. Br J Anaesth 1996; 76: 116–121.
  • Raphael JH, Butt MW. Comparison of isoflurane with propofol on respiratory cilia. Br J Anaesth 1997; 79: 473–475.
  • Englender M, Chamovitz D, Harell M. Nasal transit time in normal subjects and pathologic conditions. Otolaryngol Head Neck Surg. 1990; 103: 909–912.
  • Soane RJ, Carney AS, Jones NS, Frier M, Perkins AC, Davis SS, Illum L. The effect of the nasal cycle on mucociliary clearance. Clin Otolaryngol Allied Sci 2001; 26: 9–15.
  • Littlejohn MC, Stiernberg CM, Hokanson JA, Quinn FB, Bailey BJ. The relationship between the nasal cycle and mucociliary clearance. Laryngoscope 1992; 102: 117–120.
  • Yasny JS, White J. Environmental implications of anesthetic gases. Anesth Prog 2012; 59: 154–158.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence

Yong LI, Lizhou SUN, Denmei ZHAO, Jun OUYANG, Mei XIANG

Ebola viral disease: What should be done to combat the epidemic in 2014?

Aliye BAŞTUĞ, Hürrem BODUR

Comparison of perioperative oxidative stress in endovascular and open repair of abdominal aortic aneurysm

Orhan Veli DOĞAN, Ümit MENTEŞE, Süheyla DOĞAN, Sefer USTA, İbrahim TURAN

Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey

Sibel İBA YILMAZ, Serpil EROL, Ahmet ÖZBEK, Mehmet PARLAK

The effect of extracorporeal shock wave lithotripsy on distribution of interstitial cells of Cajal in rabbit renal pelvis and proximal ureter

Özlem BOYBEYİ, Mine Fedakar ŞENYÜCEL, Ebru Şebnem AYVA, Tutku SOYER, Mustafa Kemal ASLAN

Comparative study of virulence factors among ESβL-producing and nonproducing Pseudomonas aeruginosa clinical isolates

Fatma IBRAHIM SONBOL, Abdel Fattah Badr MOHAMED, Maha Abd El Fattah KHALIL, Sameh Samir ALI

Pregnancy-associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome

Ayşegül BAYIR, Hasan KARA, Aysel KIYICI, Bahadır ÖZTÜRK, Abdullah SİVRİKAYA, Fikret AKYÜREK

Beneficial effects of melatonin and BQ-123 on the rat testis damage caused by cigarette smoke

Hüseyin ASLAN, Hakan KESİCİ, Zafer İsmail KARACA, Birsen ÖZYURT, Ufuk TAŞ, Fatih EKİCİ, Hasan ERDOĞAN, Fikret GEVREK, Sevil ÇAYLI

Acute effect of hemodialysis on arterial elasticity

Saim SAĞ, Dilek YEŞİLBURSA, Abdulmecit YILDIZ, Kamil DİLEK, Tunay ŞENTÜRK, Osman Akın SERDAR, Ali AYDINLAR

Clinicopathological importance of Ki-67, p27, and p53 expression in gastric cancer

Muhammet ÇALIK, Elif DEMİRCİ, Eren ALTUN, İlknur ÇALIK