Lung abscess: analysis of the results as community-acquired or nosocomial

To assess the etiology, underlying disease, treatment procedures, and mortality rate of lung abscesses by dividing the patients into community-acquired lung abscess (CALA) and nosocomial lung abscess (NLA) subgroups. Materials and methods: We reviewed and analyzed data on 62 adult cases of CALA and NLA treated during 2000-2011 at a tertiary university hospital in Turkey. Results: Of these 62 patients, 44 had CALA and 18 had NLA. Etiologic microorganisms were isolated in 20 of the 44 patients (45.4%) in the CALA group and in 15 of the 18 patients (83.3%) in the NLA group. Among these patients, Staphylococcus aureus (20.0%) and Pseudomonas aeruginosa (26.7%) were the most common microorganisms in the CALA and NLA groups, respectively. Computed tomography-guided drainage was performed in 20 patients in the study and the abscess was cured in 17 (85%) patients. The overall mortality rate was 12.9%. It was 4.5% and 33.3% in the CALA and NLA groups, respectively (P < 0.05). Conclusion: Lung abscess continues to be a significant cause of morbidity and mortality despite appropriate treatment. Medical therapy is started empirically, and so it is important to separate patients into subgroups of CLA or NLA.

Lung abscess: analysis of the results as community-acquired or nosocomial

To assess the etiology, underlying disease, treatment procedures, and mortality rate of lung abscesses by dividing the patients into community-acquired lung abscess (CALA) and nosocomial lung abscess (NLA) subgroups. Materials and methods: We reviewed and analyzed data on 62 adult cases of CALA and NLA treated during 2000-2011 at a tertiary university hospital in Turkey. Results: Of these 62 patients, 44 had CALA and 18 had NLA. Etiologic microorganisms were isolated in 20 of the 44 patients (45.4%) in the CALA group and in 15 of the 18 patients (83.3%) in the NLA group. Among these patients, Staphylococcus aureus (20.0%) and Pseudomonas aeruginosa (26.7%) were the most common microorganisms in the CALA and NLA groups, respectively. Computed tomography-guided drainage was performed in 20 patients in the study and the abscess was cured in 17 (85%) patients. The overall mortality rate was 12.9%. It was 4.5% and 33.3% in the CALA and NLA groups, respectively (P < 0.05). Conclusion: Lung abscess continues to be a significant cause of morbidity and mortality despite appropriate treatment. Medical therapy is started empirically, and so it is important to separate patients into subgroups of CLA or NLA.

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  • Burrell LS. Abscess of the lung. Br Med J 1937; 2: 789–90.
  • Bartlett JG. The role of anaerobic bacteria in lung abscess. Clin Infect Dis 2005; 40: 923–5.
  • Wang JL, Chen KY, Fang CT, Hsueh PR, Yang PC, Chang SC. Changing bacteriology of adult community-acquired lung abscess in Taiwan: Klebsiella pneumoniae versus anaerobes. Clin Infect Dis 2005; 40: 915–22.
  • Takayanagi N, Kagiyama N, Ishiguro T, Tokunaga D, Sugita Y. Etiology and outcome of community acquired lung abscess. Respiration 2010; 80: 98–105.
  • Mori T, Ebe T, Takahashi M, Isonuma H, Ikemoto H, Oguri T. Lung abscess: analysis of 66 cases from 1979 to 1991. Intern Med 1993; 32: 278–84.
  • American Thoracic Society, Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired ventilator-associated, and healthcareassociated pneumonia. Am J Respir Crit Care Med 2005; 171: 388–416.
  • Akgül AG, Topçu S, Liman ŞT. Lung abscess. Turkiye Klinikleri J Thor Surg 2012; 5: 52-6 (article in Turkish with English abstract).
  • Hirshberg B, Sklair-Levi M, Nir-Paz R, Ben-Sira L, Krivoruk V, Kramer MR. Factors predicting mortality of patients with lung abscess. Chest 1999; 115: 746–50.
  • Bartlett JG. Anaerobic bacterial infections of the lung. Chest 1987; 91: 901–9.
  • Bartlett JG. Anaerobic bacterial infections of the lung and pleural space. Clin Infect Dis 1993; 16: 248–55.
  • Hammond JM, Potgieter PD, Hanslo D, Scott H, Roditi D. The etiology and antimicrobial susceptibility patterns of microorganisms in acute community-acquired lung abscess. Chest 1995; 108: 937–41.
  • Manfredi F, Daly WJ, Behnke RH. Clinical observation of acute Friedlander pneumonia. Ann Intern Med 1963; 58: 642–53.
  • Dominguez DC, Antony SJ. Actinomyces and Nocardia infections in immunocompromised and nonimmunocompromised patients. J Natl Med Assoc 1999; 91: 35–9.
  • Santos J, Palacios R, Rivero A, García-Ordóñez MA, Aliaga L, Muniain MA. Nocardiosis in patients with HIV infection. Rev Clin Esp 2002; 202: 375–8.
  • Pintado V, Gomez-Mampaso E, Fortun J, Cobo J, Navas E, Quereda C et al. Infection with Nocardia species: clinical spectrum of disease and species distribution in Madrid, Spain, 1978–2001. Infection 2002; 30: 338–40.
  • Candevir A, Kurtaran B, Kibar F, Karakoç E, Aksu HSZ, Taşova Y. Invasive device-associated nosocomial infections of a teaching hospital in Turkey; four years’ experience. Turk J Med Sci 2011; 41: 137–47.
  • Allewelt M, Schuler P, Bolcskei PL, Mauch H, Lode H. Ampicillin + sulbactam vs clindamycin +/-cephalosporin for the treatment of aspiration pneumonia and primary lung abscess. Clin Microbiol Infect 2004; 10: 163–70.
  • Kollef MH. Appropriate empiric antimicrobial therapy of nosocomial pneumonia: the role of the carbapenems. Respir Care 2004; 49: 1530–41.
  • Kelogrigoris M, Tsagouli P, Stathopoulos K, Tsagaridou I, Thanos L. CT-guided percutaneous drainage of lung abscess: review of 40 cases. JBR-BTR 2011; 94: 191–5.
  • Ha HK, Kang MW, Park JM, Yang WJ, Shinn KS, Bahk YW. Lung abscess. Percutaneous catheter therapy. Acta Radiol 1993; 34: 362–5.
  • Van Sonnenberg E, D’Agostino HB, Casola G, Wittich GR, Varney RR, Harker C. Lung abscess. CT-guided drainage. Radiology 1991; 178: 347–51.
  • Yunus M. CT guided transthoracic catheter drainage of intrapulmonary abscess. J Pak Med Assoc 2009; 59: 703–9.
  • Öktem S, Özol D, Erdinç E. The retrospective analysis of cases with lung abscess. Tuberk Toraks 2001; 49: 96–100 (article in Turkish with English summary).
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

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