Meltem Arzu YETKİN, Aliye BAŞTUĞ, Esragül AKINCI, Hürrem BODUR, Bircan KAYAASLAN, Pınar ÖNGÜRÜ, Selim Sırrı EREN, Ayşe BUT

Analysis of 161 adult patients with brucellosis

To evaluate the epidemiology, clinical features, and complications of brucellosis. Materials and methods: Between January 2005 and December 2008, 161 patients with brucellosis who were admitted to our clinic were evaluated prospectively. Results: Of the patients, 97 (60.2%) were male, and the mean age was 47 ± 17 years (range: 16-79). There were 99 patients (61.5%) classified as acute, 36 (22.4%) classified as subacute, and 6 (3.7%) classified as having a chronic infection. Relapse or reinfection was observed in 20 (12.4%) patients. Blood culture positivity rates were 60.7% and 44.8% among acute and subacute cases, respectively (P = 0.008). In 40 of 70 culture positive patients, standard Brucella tube agglutination titers were found above 1/1280 (P = 0.03). Blood culture positivity was also higher in febrile patients (P = 0.001). Complications were detected in 66 of 161 patients (41.0%). Osteoarticular system involvement was the most common complication (50 patients, 31.1%). Fever, positive blood cultures, and hepatosplenomegaly were significantly higher in the group without complications (P < 0.05). Complications were significantly lower in acute infections than in subacute infections (P < 0.05). There were also higher complication rates detected in the patients with reinfection and relapse (P < 0.05). Conclusion: In endemic regions, brucellosis is an important infectious disease causing chronic infections and complications.

Anahtar Kelimeler:

Key words: Brucellosis, complication, relapse, reinfection

Analysis of 161 adult patients with brucellosis

Keywords:

Key words: Brucellosis, complication, relapse, reinfection,

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