Pınar ZARAKOLU, Engin GÜVENER, Ahmet ARSLANTÜRK, Nilay ÇÖPLÜ, Belkıs LEVENT

8592

Comparison of Inhibitory and Bactericidal Activities of Cefoperazone + Sulbactam Against Pseudomonas aeruginosa Strains, from 1992 to 1994

In this study; inhibitory and bactericidal activities of cefoperazone + sulbactam against Pseudomonas aeruginosa strains were determined in two studies first in 1992 and second in 1994. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values were determined by following the microdilution method recommended by NCCLS (Approved Standard M7-A2 1990) protocol. P.aeruginosa strains were isolated from different clinical materials. The results of the studies were then compared to point out if the difference between MIC and MBC values were significant and if there was resistance development following two years of use. In the first study in 1992: MIC90 and susceptibility percentage were 8 mgr/ml and 99%; MBC90 and susceptibility percentage were 64 mg/ml and 90%, respectively. In the second study: MIC90 was 128 mg/ml; susceptibility percentage was 71%; MBC90 and susceptibility percentage were 256 mg/ml and 28%, respectively. When the susceptibilities were compared according to MIC90 and MBC90 values; the difference was not significant in 1992 (c2 = 0.43, p>0.05), but significant in 1994 (c2 = 18.8, p
Anahtar Kelimeler:

Pseudomonas aeruginosa, cefoperazone+sulbactam, MIC, MBC, susceptibility determination.

Comparison of Inhibitory and Bactericidal Activities of Cefoperazone + Sulbactam Against Pseudomonas aeruginosa Strains, from 1992 to 1994

In this study; inhibitory and bactericidal activities of cefoperazone + sulbactam against Pseudomonas aeruginosa strains were determined in two studies first in 1992 and second in 1994. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values were determined by following the microdilution method recommended by NCCLS (Approved Standard M7-A2 1990) protocol. P.aeruginosa strains were isolated from different clinical materials. The results of the studies were then compared to point out if the difference between MIC and MBC values were significant and if there was resistance development following two years of use. In the first study in 1992: MIC90 and susceptibility percentage were 8 mgr/ml and 99%; MBC90 and susceptibility percentage were 64 mg/ml and 90%, respectively. In the second study: MIC90 was 128 mg/ml; susceptibility percentage was 71%; MBC90 and susceptibility percentage were 256 mg/ml and 28%, respectively. When the susceptibilities were compared according to MIC90 and MBC90 values; the difference was not significant in 1992 (c2 = 0.43, p>0.05), but significant in 1994 (c2 = 18.8, p
Keywords:

Pseudomonas aeruginosa, cefoperazone+sulbactam, MIC, MBC, susceptibility determination.,

PDF
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Arşiv
Sayıdaki Diğer Makaleler

An Immunohistochemical Study of Gastric Neuroendocrine Tumors: Expression of Proliferating Cell Nuclear Antigen and P53 Oncoprotein

Gülen DOĞUSOY

S-Aroylmethyl N, N-Disubstituted Dithiocarbamates With Antiparkinson Activity

Kamil VURAL, Rahime ŞİMŞEK, Cihat ŞAFAK, Kevser EROL

The Effects of Flutamide on Lipid Profile, Insulin Sensitivity, Hirsutism and Gonadotropins in Women With Polycystic Ovary Syndrome

Mithat BAHÇECİ, Vahit YÜKSELEN, Mehmet DURSUN, Melikşah ERTEM, Alpaslan TUZCU

Significance of Cardiac Troponin T Release in Detecting Minor Myocardial Injury After Percutaneous Transluminal Coronary Angioplasty

Gülinnaz ALPER, Azem AKILLI, Ömür ERKIZAN, Taner ONAT, Filiz ÖZERKAN

Comparison of Inhibitory and Bactericidal Activities of Cefoperazone + Sulbactam Against Pseudomonas aeruginosa Strains, from 1992 to 1994

Pınar ZARAKOLU, Engin GÜVENER, Ahmet ARSLANTÜRK, Nilay ÇÖPLÜ, Belkıs LEVENT

A Comparison of the Effectiveness of Sublingual Losartan, Sublingual Captopril and Sublingual Nifedipine in Hypertensive Urgency

Yüksel GÖKEL, Saime PAYDAS, Salim SATAR

Action of Aspirin on Acetylcholine-Stimulated Tear Secretion in Rats

Zerrin KAPICIOĞLU, İ. Nuri KALYONCU, Gamze ÇAN

Is the serum CA125 level originating from endometrium influenced by exogenous estrogen administration?

Neşe ILGIN, Özdemir HİMMETOĞLU, Bülent TIRAS, Rıfat GÜRSOY, Sehri ELBEG, Onur KARABACAK

Regional Odontodisplasia Presenting as a Soft Tissue Swelling

Cahit ÜÇOK, Murat METİN, Ahmet KESKİN, Figen ÇİZMECİ

Flexion contractures in a diabetic young man ( Rosenbloom syndrome )

Serpil SAVAŞ, Selami AKKUŞ, Meltem ÇETİN, Şevket Ercan TUNÇ, Yavuz BARDAK