The use of sublingual captopril and nifedipine has been indicated in hypertensive emergencies and in patients with essential hypertension, with the assumption that by this route, there would be a faster absorption and thus a more rapid effect on blood pressure (BP) than by the oral route. A comparative study of the effects of Losartan, angiotensin II receptor antagonist, captopril and nifedipine on blood pressure was carried out in patients with hypertensive urgency. Sixty patients with hypertensive urgency were subdivided into 3 groups of 20 patients each. The first group received sublingual captopril (25 mg), the second group received sublingual nifedipine (10 mg) and the third group received sublingual losartan (50 mg). In the captopril, nifedipine and losartan groups, the mean systolic pressures at the onset of hypertensive urgency were 188.00±23, 190.00±35 and 190.50±21 mmHg respectively. At 90 minutes, in the captopril, nifedipine and losartan groups, the mean systolic blood pressures were 138.50±18, 144.50±25 and 146.25±21 mmHg respectively. In the captopril, nifedipine and losartan groups, the mean diastolic blood pressures at the onset of hypertensive urgency were 116.00±15, 121.50±22 and 109.25±14 mmHg respectively. In the captopril, nifedipine and losartan groups, at 90 minutes, mean diastolic blood pressures were 84.75±10, 95.25±19 and 88.50±12 mmHg respectively. A significant (P

The use of sublingual captopril and nifedipine has been indicated in hypertensive emergencies and in patients with essential hypertension, with the assumption that by this route, there would be a faster absorption and thus a more rapid effect on blood pressure (BP) than by the oral route. A comparative study of the effects of Losartan, angiotensin II receptor antagonist, captopril and nifedipine on blood pressure was carried out in patients with hypertensive urgency. Sixty patients with hypertensive urgency were subdivided into 3 groups of 20 patients each. The first group received sublingual captopril (25 mg), the second group received sublingual nifedipine (10 mg) and the third group received sublingual losartan (50 mg). In the captopril, nifedipine and losartan groups, the mean systolic pressures at the onset of hypertensive urgency were 188.00±23, 190.00±35 and 190.50±21 mmHg respectively. At 90 minutes, in the captopril, nifedipine and losartan groups, the mean systolic blood pressures were 138.50±18, 144.50±25 and 146.25±21 mmHg respectively. In the captopril, nifedipine and losartan groups, the mean diastolic blood pressures at the onset of hypertensive urgency were 116.00±15, 121.50±22 and 109.25±14 mmHg respectively. In the captopril, nifedipine and losartan groups, at 90 minutes, mean diastolic blood pressures were 84.75±10, 95.25±19 and 88.50±12 mmHg respectively. A significant (P