Figen Esin KAYHAN, Belgin DUMAN SÜSLEYİCİ

Heat shock protein genes in Fish

Isı şoku proteinleri balıklarda dahil olmak üzere tüm organizmalarda bulunan yüksek oranda korunmuş hücresel bir protein ailesidir. Balıklar, ısı şoku proteinlerinin düzenlenmesi ve fonksiyonel önemlerinin anlaşılmasında ideal model organizmalardır. Balıklarda ısı şoku protein gen anlatımlarını düzenleyen mekanizmalar ayrıntılı şekilde çalışılmamıştır. Bu derlemede, temel balık ısı şoku proteinlerinin fonksiyon, genomik yapı ve çevresel adaptasyonları tartışılmıştır. Balıklarda gelecekte yapılması planlanan fonksiyonel genomik araştırmalar, yüksek oranda korunmuş ısı şoku proteinlerininin fizyolojik ve ekolojik rollerinin anlaşılmasını sağlayacaktır.

Anahtar Kelimeler:

ısı şoku proteinleri, genom, balık, uyum yeteneği, genler

Balıklarda ısı şoku proteinleri

Heat shock proteins are a family of highly conserved cellular proteins present in all organisms including fish. Fish represent an ideal model organism to understand the regulation and functional significance of heat shock proteins (Hsps). The mechanism regulating the expression of Hsp genes in fish have not been studied in detail. In this review, the function, genomic structure and environmental adaptation of the major fish Hsps were discussed. Future research evaluating the functional genomics of Hsps in fish will provide substantial insight into the physiological and ecological roles of these highly conserved proteins.

Keywords:

heat shock proteins, genomes, fishes, adaptability, genes,

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