Ramazan ALDEMİR, Mahmut TOKMAKÇI

Investigation of respiratory and heart rate variability in hypertensive patients

In this paper, in order to examine the effect of respiration on heart rate variability (HRV), signal processing analyses were performed between the signal received from the periodic movement of the chest of respiration and the pulse plethysmograph (PPS) signal, providing the calculation of both the time and frequency behavior of HRV and also including pulse rate information at the same time. Respiration is used as the comparison parameter in both healthy subjects and in hypertensive patients, not only with the time and frequency components of the HRV, but also with the galvanic skin resistance simultaneously taken with body temperature and by calculating these signal changes. In our study, we aim to not only investigate the relationship between hypertension and HRV, but also to investigate the effect of respiration. Hence, in this study, 19 hypertensive patients and 19 healthy controls, who are all women, are used as subjects. As a result of the data received and analyzed from the subjects, HRV both in hypertensive and healthy subjects, the mean value of the high-frequency component and respiratory signal (RSP), and the mean value of the low-frequency/high-frequency ratio accepted as a sympathovagal balance index of the heart rate and RSP are statistically associated.

Anahtar Kelimeler:

Heart rate variability, respiratory, hypertensive patients

Investigation of respiratory and heart rate variability in hypertensive patients

Keywords:

Heart rate variability, respiratory, hypertensive patients,

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Conclusion
In future, for a better understanding of the relationship between respiration and HRV, a comparison can be made using different signal processing methods and different parameters. In particular, these operations can be implemented again on patients with respiratory disease.
J.P. Saul, D.B. Ronald, H.C. Mind, R.J. Cohen, “Transfer function analysis of autonomic regulation II. Respiratory sinus arrhythmia”, The American Journal of Physiology - Heart and Circulatory Physiology, Vol. 25, pp. 153–161, 1989.
L.C. Bernardi, A. Porta, L. Gabutti, P. Sleight, “Modulatory effect of respiration”, Autonomic Neuroscience Basic and Clinical, Vol. 90, pp. 47–56, 2001.
M.V. Pitzalis, F. Mastropasqua, F. Massari, A. Passantino, “Effect of respiratory rate on the relationships between RR interval and systolic blood pressure fluctuations: a frequency-dependent phenomenon”, The American Journal of Physiology - Heart and Circulatory Physiology, Vol. 38, pp. 332–339, 1998.
T.E. Brown, A.B. Larry, J. Koh, D.L. Eckberg, “Important respiration on human R-R interval power spectra is largely ignored”, Journal of Applied Physiology, Vol. 75, pp. 2310–2317, 1993.
M. Poyhonen, S. Syvaoja, J. Hartikainen, E. Ruokonen, J. Takal, “The effect of carbon dioxide, respiratory rate and tidal volume on human heart rate variability”, Acta Anaesthesiologica Scandinavica, Vol. 48, pp. 93–101, 2004.
L. Bernardi, J. Wdowczyck-Szulc, C. Valent, S. Castold, C. Passin, G. Spadacini, P. Sleight, “Effects of controlled breathing, mental activity and mental stress with or without verbalization on heart rate variability”, Journal of
American College of Cardiology, Vol. 35, pp. 1462–1469, 2000.
G. Strauss-Blasche, M. Moser, M. Voica, D.R. McLeod, N. Klammer, W. Marktl, “Relative timing of inspiration and expiration affects respiratory sinus arrhythmia”, Clinical and Experimental Pharmacology and Physiology, Vol.
27, pp. 601–606, 2000.
J.D. Schipke, M. Pelzer, G. Arnold, “Effect of respiration rate on short-term heart rate variability”, Journal of Clinical and Basic Cardiology, Vol. 2, pp. 92–94, 1999.
I.A. Mohamed Omar, S.A. Mohamed, “Evaluation of the analytic representation of long-record ECG and its HRV signals for congestive heart failure classification”, 28th National Radio Science Conference, pp. 1–8, 2011.
ESC/NASPE (European Society of Cardiology/North American Society of Pacing and Electrophysiology) Task Force, “Heart rate variability: standards of measurements, physiological interpretation, and clinical use”, Circula- tion, Vol. 93, pp. 1043–1065, 1996.
E.H. Hon, S.T. Lee “Electronic evaluations of the fetal heart rate patterns preceding fetal death, further observa- tions”, American Journal of Obstetrics and Gynecology, Vol. 87, pp. 814–826, 1965.
M. Piepoli, P. Sleight, S. Leuzzi, F. Valle, G. Spadacini, C. Passino, J.A. Johnston, L. Benardi, “Origin of respiratory sinus arrhythmia in conscious humans an important role for the arterial carotid baroreceptor”, Circulation, Vol. 95,
pp. 1813–1821, 1997.
A. Melcher, “Respiratory sinus arrhythmia in man. A study in heart rate regulating mechanisms”, Acta Physiologica Scandinavica, Vol. 435, pp. 1–31, 1976.
J.S. Wu, F.H. Lu, Y.C. Yang, T.S. Lin, J.J. Chen, C.H. Wu, Y.H. Huang, C.J. Chang, “Epidemiological study on the effect of pre-hypertension and family history of cardiac autonomic function”, Journal of American College of
Cardiology, Vol. 51, pp. 1896–1901, 2008.
D.R. Seals, N.O. Suwarno, M.J. Joyner, C. Iber, J.G. Copeland, J.A. Dempsey, “Respiratory modulation of muscle sympathetic nerve activity in intact and lung denervated humans”, Circulation Research, Vol. 72, pp. 440–454, 1993.
N. Sasano, A.E. Vesely, J. Hayano, H. Sasano, R. Somogyi, D. Preiss, K. Miyasaka, H. Katsuya, S. Iscoe, J.A. Fisher, “Direct effect of PaCO2on respiratory sinus arrhythmia in conscious humans”, The American Journal of Physiology - Heart and Circulatory Physiology, Vol. 282, pp. 973–976, 2002.
F. Yasuma, J. Hayano, “Respiratory sinus arrhythmia: why does the heartbeat synchronize with respiratory rhythm?”, Chest, Vol. 25, pp. 683–690, 2004.
M.A. Cohen, M. Taylor, “Short-term cardiovascular oscillations in man: measuring and modelling the physiologies”, Journal of Physiology, Vol. 542, pp. 669–683, 2002.
Q.A. Zhang, A.I. Manriquez, C.Y. Medigue Papelier, M. Sorine, “An algorithm for robust and efficient location of T-wave ends in electrocardiograms”, IEEE Transactions on Biomedical Engineering, Vol. 53, pp. 2544–2552, 2006.
I.C. Christie, “Multivariate discrimination of emotion-specific autonomic nervous system activity”, MSc, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA, 2002.
M.H. Asyali, “Discrimination power of long-term heart rate variability measures”, Proceedings of the 25th Annual International Conference of the IEEE Engineering Medicine and Biology Society, pp. 200–203, 2003.
J.G. Proakis, D.G. Manolakis, Digital Signal Processing Principles, Algorithms, and Applications, Upper Saddle River, NJ, USA, Prentice Hall, 1996.