Lipom ve liposarkomlu hastalarda NLR, MLR ve PLR'nin tanısal rolü

Amaç: Bu çalışmanın amacı, lipoma ve liposarkomlu hastalarda Nötrofil / lenfosit oranının (NLR), Monosit / lenfosit oranının (MLR) ve Trombosit-lenfosit oranının (PLR) tanısal rolünü araştırmaktır. Gereç ve Yöntemler: 2015-2019 yılları arasında kurumumuzda lipom ve liposarkom nedeniyle opere edilen hastalar bu retrospektif çalışmaya alındı. Bu çalışmaya 44 lipoma ve 48 liposarkomlu 92 hasta dahil edildi. Tedaviden önce tam kan sayımı sonuçları geriye dönük olarak analiz edildi. Yukarıda belirtilen çalışma grubuna benzer yaş ve cinsiyete benzer kırık, enfeksiyon veya tümörler dışındaki nedenlerle aynı merkeze kabul edilen tam kan sayımı sonuçları olan 94 hasta sağlıklı kontroller olarak dahil edildi. Bulgular: Çalışmaya dahil edilen lipom, liposarkom ve kontrol gruplarının yaş ortalaması sırasıyla 55.3 ± 11.6, 48.9 ± 14.7 ve 52.1 ± 11.7 idi. Lipomların% 50'si uylukta,% 40.9'u omuzda bulunurken, liposarkomların% 72.9'u uylukta bulunur. Liposarkom grubunun NLR değerleri kontrol grubundan anlamlı olarak yüksekti. PLR değerlerinin gruplar arasında anlamlı farklılık göstermediği gözlendi. Lipozarkom grubunda MLR değerlerinin lipoma grubuna göre istatistiksel olarak anlamlı derecede yüksek olduğu kaydedildi. NLR için anlamlı fakat zayıf bir AUC değeri (AUC = 0.620, p = 0.020) elde edildi. Bu kesme değerlerinin kesme değeri ve duyarlılığı, özgüllüğü, + LHR, PPV ve NPV değerleri incelendiğinde NLR 1.83 ve üzeri değerler; Liposarkom için tanısal yaklaşımda öngörülebilirliğinin zayıf olduğuna dikkat çekti. Sonuç: Sonuç olarak, lipom ve liposarkom, benign ve malign yumuşak doku tümörlerinin en yaygın formlarıdır. NLR ve MLR, liposarkom tanısında değerli olabilir, ancak bu konuda daha fazla çalışmaya ihtiyaç vardır.

Anahtar Kelimeler:

lipom, liposarkom, nötrofil/lenfosit oranı, monosit-lenfosit oranı, trombosit-lenfosit oranı

Diagnostic role of NLR, MLR and PLR in patients with lipoma and liposarcoma

Aim: The aim of this study is to investigate the diagnostic role of Neutrophil-to-lymphocyte ratio (NLR), Monocyte-to-lymphocyte ratio (MLR) and Platelet-to-lymphocyte ratio (PLR) in patients with lipoma and liposarcoma. Material and Methods: Patients operated for lipoma and liposarcoma at our institution between 2015 and 2019 were included in this retrospective study. A total of 92 patients with 44 lipoma and 48 liposarcoma were included in this study. The results of the complete blood count before treatment were retrospectively analyzed. 94 patients with complete blood count results admitted to the same center for reasons other than fracture, infection or tumors with similar age and sex to the aforementioned study group were included as healthy controls. Results: The average age of lipoma, liposarcoma and control groups included in the study was 55.3 ± 11.6, 48.9 ± 14.7 and 52.1 ± 11.7, respectively. While 50% of lipomas are located on the thigh and 40.9% are on the shoulder, 72.9% of the liposarcomas are located on the thigh. NLR values of the liposarcoma group were significantly higher than the control group. It was observed that PLR values did not differ significantly between groups. It was noted that MLR values were statistically significantly higher in the liposarcoma group than in the lipoma group. A significant but weak AUC value (AUC = 0.620, p = 0.020) was obtained for NLR. When the cut-off value and sensitivity, specificity, + LHR, PPV and NPV values of these cut off values are examined, NLR 1.83 and above values; It pointed out that his predictability was poor in the diagnostic approach for liposarcoma. Conclusion: Consequently, lipoma and liposarcoma are the most common forms of benign and malignant soft tissue tumors. NLR and MLR may be valuable in the diagnosis of liposarcoma, but more studies are needed in this regard.

Keywords:

Lipoma, Liposarcoma, Neutrophil-to-lymphocyte ratio, Monocyte-to-lymphocyte ratio, Platelet-to-lymphocyte ratio,

PDF

___

1. Mangham, D., et al., Clinical outcomes of deep atypical lipomas (well-differentiated lipoma-like liposarcomas) of the extremities. 2005.
2. Amato, G., et al., Well differentiated" lipoma-like" liposarcoma of the sigmoid mesocolon and multiple lipomatosis of the rectosigmoid colon. Report of a case. Hepato-gastroenterology, 1998. 45(24): p. 2151-2156.
3. Montgomery, E. and C. Fisher, Paratesticular liposarcoma: a clinicopathologic study. The American journal of surgical pathology, 2003. 27(1): p. 40-47.
4. Akdeniz, H., et al., Surgery and Functional Results of Pathological Fractures of Long Bones of Lower Extremities in Malignant Tumors.
5. Skorpil, M., et al., Soft-tissue fat tumours: differentiating malignant from benign using proton density fat fraction quantification MRI. Clinical radiology, 2019. 74(7): p. 534-538.
6. Aggarwal, B.B., R. Vijayalekshmi, and B. Sung, Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clinical cancer research, 2009. 15(2): p. 425-430.
7. Naess, A., et al., Role of neutrophil to lymphocyte and monocyte to lymphocyte ratios in the diagnosis of bacterial infection in patients with fever. Infection, 2017. 45(3): p. 299-307.
8. Obuchowski, N.A., Receiver operating characteristic curves and their use in radiology. Radiology, 2003. 229(1): p. 3-8.
9. Metz, C.E. Basic principles of ROC analysis. in Seminars in nuclear medicine. 1978. WB Saunders.
10. Coussens, L.M. and Z. Werb, Inflammation and cancer. Nature, 2002. 420(6917): p. 860-867.
11. Balkwill, F. and A. Mantovani, Inflammation and cancer: back to Virchow? The lancet, 2001. 357(9255): p. 539-545.
12. Kusumanto, Y.H., et al., Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor. Angiogenesis, 2003. 6(4): p. 283-287.
13. Hu, J., et al., Diagnostic value of alpha-fetoprotein combined with neutrophil-to-lymphocyte ratio for hepatocellular carcinoma. BMC gastroenterology, 2018. 18(1): p. 186.
14. Li, M.X., et al., Prognostic role of neutrophil‐to‐lymphocyte ratio in colorectal cancer: a systematic review and meta‐analysis. International journal of cancer, 2014. 134(10): p. 2403-2413.
15. Kemal, Y., et al., Elevated serum neutrophil to lymphocyte and platelet to lymphocyte ratios could be useful in lung cancer diagnosis. Asian Pac J Cancer Prev, 2014. 15(6): p. 2651-4.
16. Nikolić, I., et al., Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio help identify patients with lung cancer, but do not differentiate between lung cancer subtypes. Croatian medical journal, 2016. 57(3): p. 287-292.