Monosit yüksek/ dansiteli lipoprotein oranı ve yüksek sensiviteli c- reaktif protein değelerinin izole koroner arter ektazisi ile ilişkisi

Amaç: Izole koroner arter ektazisi (İKAE), koroner arter hastalığının az görülen bir formu olup, aterosklerotik koroner arter hastalığna benzer mortalite ve morbidite oranına sahiptir. Monosit yüksek dansiteli lipoprotein (HDL) oranı ( MHO) klinikte yeni tanımlanan inflamasyon belirteçlerinden biridir. Çalışamızda MHO ve klinikte inflamasyon belirteci olarak sıkça kullanılan yüksek duyarlıklı C-reaktif protein (Yd-Crp) ile İKAE arasıdaki ilişki araştırılmıştır. Gereç ve Yöntemler: Çalışmamızda retrospektif olarak elektif koroner yapılan hastalar incelenmiştir. Hastaneye başvuruşunda koroner anjiografi hemen öncesinde alınan örneklerden Yd-Crp ve MHO oranı hesaplanmıştır. Bulgular: Toplam 98 (61, %62 erkek ) hasta geriye dönük incelenmiş, 28 (%28.6) hastada Diabetes Mellitus saptamıştır. İKAE hasta sayısı 68 (%69.8) olarak bulunmuştur. MHO ve Yd-Crp ; İKAE grubunda normal koroner arterlere sahip gruba göre anlamlı olarak yüksek saptandı (Sırasıyla; MHO: 0.0153 (0.007-0.130)ve 0.0111 (0.005-0.020), p

Anahtar Kelimeler:

Koroner arter ektazisi, Monosit yüksek dansiteli lipoprotein (HDL) oranı, yüksek duyarlılıklı c- reaktif protein

Monocyte to high-density lipoprotein ratio and high sensitive c-reactive protein levels in patients with isolated coronary artery ectasia

Aim: Isolated coronary artery ectasia (ICAE) is a rare form of coronary artery disease and has almost same mortality and morbidity rate to atherosclerotic coronary artery disease. Monocyte to HDL-cholesterol ratio (MHR) has been entered the literature as a new inflammatory indicator in various cardiovascular disease. In this study we want to investigate relationship between inflammatory and oxidative markers that high sensitive C reactive protein (Hs-Crp), MHR and ICAE. Material and Methods: We retrospectively observed patients who underwent elective coronary angiography. Patients with ICAE and normal coronary arteries included in the study. MHR and Hs-Crp levels were observed just before the coronary angiography procedure. Results: A total of 98 patients (61, 62 % men) patients were included in this study and 28 (28.6%) of them had DM. 68 (69.3%) of patients had ICAE. MHR was significantly higher in patients with ICAE (0.0153 (0.007-0.130)ve 0.0111 (0.005-0.020), p

Keywords:

coronary ectasia, monocyte to high-density lipoprotein ratio, high sensitive c reactive protein,

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