Kiremitçi Menemşe GÜMÜŞDERELİOĞLU, Günday DENİZ

Synthesis, characterization and in vitro degradation of poly (DL-lactide)/poly (DL-lactide-co-glycolide) films

Poly(dl-lactide) (PLA) homopolymers and poly(dl-lactide-co-glycolide) (PLGA) copolymers were synthesized from their cyclic dimers, i.e. dl-lactide and glycolide, by ring-opening polymerization in the presence of catalyst stannous octoate and chain control agent lauryl alcohol. The effects of catalyst and chain control agent concentrations, reaction temperature, and reaction time on the molecular weight and yield of homopolymers were studied. The homopolymers were obtained in the intrinsic viscosity 0.1 to 1.0 dl/g range by changing the polymerization conditions. The copolymers in two different lactide/glycolide ratios, i.e. 90:10 and 70:30 and in 0.60 intrinsic viscosity were synthesized. The polymers were further characterized by IR, 1H-NMR, 13C-NMR, and DSC. In vitro degradation studies were conducted at 37°C in pH 7.4 phosphate buffered saline. The results showed that the intrinsic viscosities of all polymers decrease continuously until 0.20 dl/g after exposure to phosphate buffered saline and then a very sharp mass loss occurs.

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1. H. Fukuzaki, M. Yoshida, M. Asano, Y. Aiba, and I. Kaetsu, Eur. Polym. J., 24 (1988) 1029-1036.
2. H. Fukuzaki, M. Yoshida, M. Asano, and M. Kumakura, Eur. Polym. J., 25 (10) (1989) 1019-1026.
3. D. K. Gilding, and A. M. Reed, Polymer, 20 (1979) 1459-1464.
4. P. B. Deasy, M. P. Finan, and M. J. Meegan, J. Microencapsulation 6, 3 (1989) 369-378.
5. K. J. Zhu, L. Xiangzhou, Y. Shilin, J. Polym. Sci., Polym. Lett. Ed., 24 (1986) 331-337.
6. K. J. Zhu, L. Xiangzhou, Y. Shilin, J. Appl. Polym. Sci., 39 (1990) 1-9.
7. H. B. Hopfenberg, in: Controlled Release Polymeric Formulations, p. 26, ACS Symp. Ser., Vol. 33, D. R. Paul and F. W. Harris (Eds) American Chemical Society, Washinton, DC (1976).
8. R. K. Agarwal, D. H. Robinson, G. I. Maze, R. A. Reinhardt, J. Controlled Release, 23 (1993) 137-146.
9. S. S. Shah, Y. cha, and C. G. Pitt, J. Controlled Release 18, (1992) 261-270.
10. M. Kiremitci- Gümüşderelioglu, G. Deniz, J. Biomat. Sci: Poly. Edn., (1998) (in press).
11. O. F. Solomon, and I. Z. Ciuta, J. Appl. Polym. Sci. 6, (1962) 683-687.
12. H. Fukuzaki, M. Yoshida, M. Asano, M. Kumakura, T. Mashimo, H. Yuasa, K. Imai, H. Yamanaka, Biomaterilas, 12 (1991) 433-437.
13. E. A. Schmitt, D. R. Flanagan, R. J. Linhardt, J. Pharm. Sci. 82, 3 (1993) 326-331. 161