Sajjad AHMAD, Saqib ALI, Saira SHAHZADI, Fiaz AHMED, Khalid M. KHAN

New Complexes of Organotin(IV) 2-(N-Maleoylamino)-2-methylpropanoate: Synthesis, Spectroscopic Characterization and Biological Activity

Organotin(IV) complexes of 2-(N-maleoylamino)-2-methylpropanoate were prepared by treating the ligand acid with diorganotin dichloride and triorganotin chloride in 1:2 and 1:1 molar ratios, respectively. These reactions proceeded smoothly to completion and the complexes formed were characterized by elemental analysis, infrared, multinuclear NMR (1H, 13C, 119Sn) and mass spectrometry. The biological activities of the tin complexes were studied by screening the compounds against various animal and plant pathogens. These results show that triorganotin(IV) carboxylates are more active against the animal and plant pathogens tested as compared to diorganotin dicarboxylates.

Anahtar Kelimeler:

Organotin(IV) carboxylates, spectroscopic studies, biological activity.

New Complexes of Organotin(IV) 2-(N-Maleoylamino)-2-methylpropanoate: Synthesis, Spectroscopic Characterization and Biological Activity

Keywords:

Organotin(IV) carboxylates, spectroscopic studies, biological activity.,

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L. Pellerito and L. Nagy, Coord. Chem. Rev., 224, 111 (2002).
S.J. Blunden, P.A. Cussack and R. Hill, The Industrial Uses of Tin Compounds., Royal Society of
Chemistry, London, (1985).
Y. Arakawa, Main Group Met. Chem., 17, 225 (1994).
M. Gielen, M. Boualam, B. Bahieu and E.R.T. Tiekink, Appl. Organomet. Chem., 8, 19 (1994).
A. Kumari, I. Singh and J.P. Tandon, Appl. Organomet. Chem., 9, 127 (1995).
H. Masood, S. Ali, M. Mazhar, S. Shahzadi and K. Shahid, Turk. J. Chem., 28, 75 (2004).
K. Shahid, S. Ali, S. Shahzadi and Z. Akhtar, Turk. J. Chem., 27, 209 (2003).
S. Ahmad, S. Ali, F. Ahmed, M.H. Bhatti, A. Badshah, M. Mazhar and K.M. Khan, Synth. React. Inorg.
Met.-Org. Chem., 32, 1521 (2002).
S. Ali, M. Danish and M. Mazhar, Heteroatom. Chem., 8, 273 (1997).
S. Shahzadi, M.H. Bhatti, K. Shahid, S. Ali, S.R. Tariq, M. Mazhar and K.M. Khan, Monatsh. Chem., 133, 1089 (2002).
A. Badshah, S. Anwer, S. Ali, M. Danish, M. Mazhar and M.I. Chaudhary, Pak. J. Pharmacol., 13, 49 (1996).
A. Kalsoom, M. Mazhar, S. Ali, M.F. Mahon, K.C. Molloy and M.I. Chaudhary, Appl. Organomet. Chem., 11, 47 (1997).
W.F.F. Armarego and C.L.L. Cahi, Purification of Laboratory Chemicals., 5thEd., Butterworth: Oxford, (2003).
H.K. Sharma, S. Lata, K.K. Sharma, K.C. Molloy and P.C. Waterfield, J. Organomet. Chem., 9, 353 (1988).
C. Vasta, V.K. Jain, T. Kesavadas and E.R.T. Tiekink, J. Organomet. Chem., 135, 410 (1991).
G.K. Sandhu and N.S. Boparoy, J. Organomet. Chem., 423,183 (1992).
T. P. Lockhart, W.F. Manders and E.M. Holt, J. Am. Chem. Soc., 108, 6611 (1986).
M. Danish, S. Ali, A. Badshah, M. Mazhar, H. Masood, A. Malik and G. Kehr, Synth. React. Inorg. Met.-Org. Chem., 27, 863 (1997).
A.K. Gupta, S. Sharma, H.P.S. Chauhan and R.J. Rao, Synth. React. Inorg. Met.-Org. Chem., 21, 497 (1991).
R. Willem, H. Dialil, P. Brockaert, M. Biesemans, L. Ghys, K. Nooter, D. de Vos, F. Ribot and M. Gielen, Main Group Met. Chem., 20, 535 (1997).
M. Gielen, A. El-Khloufi, M. Biesemans and R. Willem, Appl. Organomet. Chem., 7, 119 (1993).
M. Gielen, J.M. Piret, M. Biesemans, R. Willem and A. El-Khloufi, Appl. Organomet. Chem., 6, 59 (1992).
M. Dansih, S. Ali, M. Mazhar, A. Badshah, M.I. Choudhary, A.G. Helmut and G. Kehr, Polyhedron., 14, 3115 (1995).
M.H. Bhatti, S. Ali, H. Masood, M. Mazhar and S.I. Qureshi, Synth. React. Inorg. Met.-Org. Chem., 30, 1715 (1997).
H. Blank and G. Rewbell, Arch. Derm., 92, 319 (1965).
S.S. Shaukat, N.A. Khan and F. Ahmed, Pak. J. Bot., 12, 97 (1980).
Atta-ur-Rahman, M.I. Choudhary and W.J. Thomsen, Bioassay Techniques for Drug Development; Harward Academic Press: Amsterdam, (2001).