Muhammad Tahir HUSSAIN, Nasim Hasan RAMA, Shahid HAMEED, Zahid SHAFIQ, Muhammad ARFAN, Ghulam ABBAS

Synthesis of some new dihalophenyl-and dihalobenzylisocoumarins and their (dl) 3,4-dihydroderivatives

ISSN: 1300-0527
Yayın Aralığı: 6
Yayıncı: TÜBİTAK

3-Dihalophenyl- and dihalobenzylisocoumarins (3a-c) were synthesized by condensation of homophthalic acid (1) with dihalobenzoyl- and dihalophenylacetyl chlorides (2a-c), respectively. The alkaline hydrolysis of these isocoumarins (2a-c) afforded keto-acids (4a-c). (dl)-3-(Dihalophenyl)- and (dl)-3-(dihalobenzyl)- 3,4-dihydroisocoumarins (6a-c) were obtained by reduction of keto-acids (4a-c) to racemic hydroxy-acids (5a-c) followed by cyclodehydration using acetic anhydride.

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