A new series of Cu(II) and Ni(II) complexes of NO bidentate 4-NO$_{2}$-benzoylhydrazones: synthesis, characterization, and biological studies
A series of new nickel(II) and copper(II) hydrazone complexes \textbf{1--14}, containing a bidentate NO-donor hydrazone ligand, derived from 4-nitrobenzoylhydrazide and several aliphatic and aromatic aldehydes were synthesized, and their chemical structures were confirmed by means of FT-IR, UV-Vis, $^{1}$H and $^{13}$C NMR, mass spectral data, conductance measurements, and elemental analyses. The spectral data of the newly synthesized complexes show the formation of a 1:2 [metal:ligand] ratio. The ligands and their complexes were also investigated for their possible in vitro antimicrobial activities against \textit{S. aureus}, \textit{S. epidermidis}, \textit{E. coli}, \textit{K. pneumonia}, \textit{P. aeruginosa}, \textit{P. mirabilis}, \textit{E. faecalis}, and \textit{C. albicans}. Among the fourteen new complexes synthesized, complex Cu(L$_{4})_{2}$ (\textbf{7}) containing a direct aromatic moiety in the ligand (HL$_{7})$ was found to be most active against selected test microorganisms.
A new series of Cu(II) and Ni(II) complexes of NO bidentate 4-NO2 -benzoylhydrazones: synthesis, characterization, and biological studies
A series of new nickel(II) and copper(II) hydrazone complexes \textbf{1--14}, containing a bidentate NO-donor hydrazone ligand, derived from 4-nitrobenzoylhydrazide and several aliphatic and aromatic aldehydes were synthesized, and their chemical structures were confirmed by means of FT-IR, UV-Vis, $^{1}$H and $^{13}$C NMR, mass spectral data, conductance measurements, and elemental analyses. The spectral data of the newly synthesized complexes show the formation of a 1:2 [metal:ligand] ratio. The ligands and their complexes were also investigated for their possible in vitro antimicrobial activities against \textit{S. aureus}, \textit{S. epidermidis}, \textit{E. coli}, \textit{K. pneumonia}, \textit{P. aeruginosa}, \textit{P. mirabilis}, \textit{E. faecalis}, and \textit{C. albicans}. Among the fourteen new complexes synthesized, complex Cu(L$_{4})_{2}$ (\textbf{7}) containing a direct aromatic moiety in the ligand (HL$_{7})$ was found to be most active against selected test microorganisms.
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- E. 5 K pneumoniae P. C. 1 S. S E. P. E. K pneumoniae P. C. on a Mattson 1000 spectrometer in the 4000–400 cm −1 range, in the form of KBr pellets at room temperature.
- The molar conductance of 10 −3 M solutions of the complexes in DMSO was measured at room temperature on a digital WPA CMD 750 conductivity meter. UV-Vis spectra were recorded using a Shimadzu UV-1650 PC spectrophotometer. Melting points were measured with a B¨uchi Melting Point B-540 apparatus. The elemental analyses were determined on a Thermo Finnigan Flash EA 1112 Series Elemental Analyzer. 2. Syntheses 2.1. Synthesis of hydrazones
- Escherichia coli ATCC 25922, Klebsiella pneumonia ATCC 4352, Pseudomonas aeruginosa ATCC 27853,
- The trays were covered and placed in plastic bags to prevent evaporation. The trays containing Mueller–Hinton broth were incubated at 35 ◦ C for 46–50 h. The MIC was defined as the lowest concentration of compound giving complete inhibition of ◦ C for 18–20 h while the trays containing RPMI-1640 medium were incubated at 35 visible growth. As a control, antimicrobial effects of the solvents were investigated against test microorganisms.
- The results were evaluated according to the values of the controls. Kuriakose, M.; Kurup, M. R. P.; Suresh, E. Polyhedron 2007, 26, 2713–2718.
- John, R. P.; Sreekanth, A.; Kurup, M. R. P.; Usman, A.; Ibrahim, A. R.; Fun, H. K. Spectrochim. Acta Part A , 59, 1349–1358.
- Geary, W. J. Coord. Chem. Rev. 1971, 7, 81–122.
- Thompson, L. K.; Lee, F. L.; Gabe, E. J. Inorg. Chem. 1988, 27, 39–46.
- Sharaby, C. M. Spectrochim. Acta A 2007, 66, 1271–1278.
- Herrera, R. P.; Roca-L´opez, D.; Navarro-Moros, G. Eur. J. Org. Chem. 2010, 8, 1450–1454.
- Rueping, M.; Maji, M. S.; Kucuk, H. B.; Atodiresei, I. Angew. Chem. Int. Ed. 2012, 51, 12864–12868.
- Ghosh, T.; Mondal, B.; Ghosh, T.; Sutradhar, M.; Mukherjee, G.; Drew, M. G. B. Inorg. Chem. Acta 2007, 360, –1761.
- Affan, M. A.; Foo, S. W.; Jusoh, I.; Hanapi, S.; Tiekink, E. R. T. Inorg. Chem. Acta 2009, 362, 5031–5037.
- Karvembu, R.; Hemalatha, S.; Prabhakaran, R.; Natarajan, K. Inorg. Chem. Commun. 2003, 6, 486–489.
- Clinical and Laboratory Standards Institute. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically; Approved Standard–7th ed., M7-A7 ; CLSI: Wayne, PA, USA, 2006.
- Clinical and Laboratory Standards Institute. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard–2nd ed., M27 A2 ; CLSI: Wayne, PA, USA, 1997.