The effects of mistletoe (Viscum album L. subsp. album) extracts on ısolated ıntestinal contractions
Halk ilaçları eski çağlardan bu yana bağırsak ağrıları gibi problemlerin tedavi edilmesinde alternatif ya da tamamlayıcı bir yol olmuşlardır. Ökseotu, tüm dünyada, ağaçlarda büyüyen gelişen yarı parazit bir bitkidir ve bağırsak kasılmalarına karşı yaygın olarak kullanılmaktadır. Çalışmamızda Viscum album subsp. album yapraklarının, bitkisinden dondurulup-kurutulma (Grup 1) ve sıcak su (Grup 2) ile ekstraksiyon suretiyle hazırlanan ekstraktların, izole edilmiş ince bağırsağın farklı segmentlerinde (duodenum, jejunum, ileum) asetilkolin ile oluşturulmuş kasılmalar üzerine olan etkilerini inceledik. 1. Gruptaki ekstraktlar tüm bağırsak segmentlerinde kasılmaları düşürdü (P < 0.05). En güçlü gevşetici etki jejunumda, en düşük etki ise duodenumda gözlendi. 2. Gruptaki ekstraktlar 1. Gruptaki ekstraktlardan daha yüksek dozlarda segmental kasılmaları etkiledi (P < 0.05); kasılmalardaki düşüş jejunumda daha fazla, daha düşük ileum ve en düşük etki duodenumda gözlendi. Ökseotu ekstraktlarının kasılmaları doza ve hazırlama yöntemlerine bağlı olarak etkilediği görülmektedir. Sonuç olarak ökseotu ekstraktları bağırsak hareket problemlerine karşı etkili olabilmekte ve bağırsak kasılmalarında tedavi edici ilaç olarak bir potansiyeli bulunmaktadır.
Ökseotu (Viscum album L. subsp. album) ekstraktlarının izole bağırsak kasılmaları üzerine etkileri
Throughout history folk medicine has served as an alternative or complimentary method of treating disorders like intestinal colic. Mistletoe is a common name for many species of semi-parasitic plants that grow on trees throughout the world, and has been used widely to treat intestinal colic. We conducted a study to evaluate the effect of freeze-dried (group 1) and heat-treated (group 2) extracts of Viscum album subsp. album leaves on contractions induced by acetylcholine in isolated hamster intestinal segments (duodenum, jejunum, and ileum). Freeze-dried extracts decreased intestinal contractions in all the intestinal segments (P < 0.05). The strongest relaxant effect was observed in the jejunum and the weakest was seen in the duodenum. Higher doses of heat-treated extracts were required to affect segmental contractions than that of freeze-dried extracts (P < 0.05); heat-treated extracts had the greatest effect on reducing contractions in the jejunum and the least effect in the duodenum. Mistletoe extracts affected the level of contractions in a dose- and extraction preparation-dependent manner. The results of this study show that mistletoe extracts could be effective against intestinal motility problems and that they have potential use as a therapeutic remedy for intestinal colic.
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