Changes in Liver Cytoplasmic Glutathione-S-Transferase and Microsomal Nitrosodimethylamine Demethylase Activities in Chicks Obtained Following Daminozide Treatment
In this study, microsomal nitrosodimethylamine demethylase (NDMAd) and cytoplasmic glutathione-s-tarnsferase (GST) activities in the livers of chicks obtained from the LD 10 (3 mg/ml) and LD 30 (9 mg/ml) doses of daminozide (Succinic acid 2,2-Dimethylhydrazide) injected Ross-Pm-3 fertilized chicken eggs were investigated. Spectrophotometric determination of NDMAd activity was performed at 412 nm by the detection of yellow coloured compound formed as a product of the reaction of formaldehyde with Nash reagent. No significant increase was observed in NDMAd activity (P>0.05) of the group treated with LD 10 dose although NDMAd activity was found to be significantly increased (P
Anahtar Kelimeler:
Daminozide, Nitrosodimethylamine Demethylase, Cytochrome P-450IIE1 Glutathione-S-Transferase.
Changes in Liver Cytoplasmic Glutathione-S-Transferase and Microsomal Nitrosodimethylamine Demethylase Activities in Chicks Obtained Following Daminozide Treatment
In this study, microsomal nitrosodimethylamine demethylase (NDMAd) and cytoplasmic glutathione-s-tarnsferase (GST) activities in the livers of chicks obtained from the LD 10 (3 mg/ml) and LD 30 (9 mg/ml) doses of daminozide (Succinic acid 2,2-Dimethylhydrazide) injected Ross-Pm-3 fertilized chicken eggs were investigated. Spectrophotometric determination of NDMAd activity was performed at 412 nm by the detection of yellow coloured compound formed as a product of the reaction of formaldehyde with Nash reagent. No significant increase was observed in NDMAd activity (P>0.05) of the group treated with LD 10 dose although NDMAd activity was found to be significantly increased (P
Keywords:
Daminozide, Nitrosodimethylamine Demethylase, Cytochrome P-450IIE1 Glutathione-S-Transferase.,
- ISSN: 1300-0152
- Yayın Aralığı: Yılda 6 Sayı
- Yayıncı: TÜBİTAK
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