Sinem BALTACI, Hatice Efsun KOLATAN, Osman YILMAZ, Bijen KIVÇAK

Anti-inflammatory activity of Anthemis aciphylla var. aciphylla Boiss.

Ethanolic (EEAA) and sesquiterpene lactone (SEAA) extracts of the aerial parts of Anthemis aciphylla var. aciphylla Boiss. (Asteraceae) were evaluated for anti-inflammatory activity on carrageenin-induced paw edema (acute model) and cotton pellet-induced granuloma (chronic model) in rats. In carrageenin-induced paw edema, EEAA and SEAA at intraperitoneal doses of 50, 100, and 200 mg/kg dose-dependently inhibited the paw edema. In cotton pellet-induced granuloma, the oral administration of EEAA and SEAA at 50, 100, and 200 mg/kg dosages was also found to significantly inhibit granuloma tissue formation.

Anahtar Kelimeler:

Key words: Anthemis aciphylla, anti-inflammatory activity, carrageenin, paw edema, cotton pellet

Anti-inflammatory activity of Anthemis aciphylla var. aciphylla Boiss.

Keywords:

Key words: Anthemis aciphylla, anti-inflammatory activity, carrageenin, paw edema, cotton pellet,

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