Etlik Piliç Rasyonuna İlave Edilen Fukoksantinin Bazı Kan Parametreleri Üzerine Etkisi

Bu çalışma, etlik piliç rasyonuna ilave edilen fukoksantinin serumda lipid profili ve bazı metabolik parametreler üzerine etkisini belirlemek amacıyla yapılmıştır. Çalışmada toplam 180 adet günlük erkek civciv (Ross 308) kullanılmıştır. Deneme 42 gün sürdürülmüştür. Gruplandırma Kontrol (K), F1 ve F2 grupları şeklinde yapılmıştır ve gruplara bazal rasyona ilave olarak sırasıyla 0, 100 ve 200 mg/kg rasyon fukoksantin katılmıştır. Biyokimyasal analizler çalışmanın sonunda (43. gününde) her gruptan 10 adet hayvandan alınan serum numunelerinde yapılmıştır. Fukoksantin uygulamasının sadece F2 grubunda serum trigliserit (TG) seviyesini arttırdığı, total kolesterol (TK), yüksek yoğunluklu lipoprotein kolesterol (HDL-K) ve düşük yoğunluklu lipoprotein kolesterol (LDL-K) seviyelerini etkilemediği tespit edilmiştir. Serum glikoz, kalsiyum, fosfor ve magnezyum seviyelerinin tüm gruplarda benzer olduğu belirlenmiştir. F2 grubunun total protein ve albümin seviyeleri K grubuna benzer olurken F1 grubuna göre önemli düzeyde azaldığı tespit edilmiştir. Ayrıca F2 grubunun ürik asit seviyesinin K grubuna göre önemli düzeyde azaldığı belirlenmiştir. Sonuç olarak fukoksantinin serum parametrelerini sınırlı düzeyde etkilediği görülmüştür.

Effect of Dietary Fucoxanthin Supplementation on Some Blood Parameters in Broilers

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Armstrong GA. 1997. Genetics of eubacterial carotenoid biosynthesis: a colorful tale. Annu. Rev. Microbiol., 51(1): 629-659.
Beppu F, Niwano Y, Tsukui T, Hosokawa M, Miyashita K. 2009. Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice. J.Toxicol Sci., 34(5): 501-510.
Beppu F, Hosokawa M, Niwano Y, Miyashita K. 2012. Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-A y mice. Lipids Health Dis., 11(1): 112.
Eom SH, Kim YM, Kim SK. 2012. Antimicrobial effect of phlorotannins from marine brown algae. Food Chem. Toxicol., 50(9): 3251-3255.
Ha AW, Kim WK. 2013. The effect of fucoxanthin rich power on the lipid metabolism in rats with a high fat diet. Nutr. Res. Pract., 7(4): 287-293.
Hosokawa M, Okada T, Mikami N, Konishi I, Miyashita K. 2009. Bio-functions of marine carotenoids. J. Food Sci Biotechnol., 18(1): 1-11.
Hosokawa M, Miyashita T, Nishikawa S, Emi S, Tsukui T, Beppu F, Miyashita K. 2010. Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice. Arch. Biochem. Biophys., 504(1): 17-25.
Iwasaki S, Widjaja-Adhi MAK, Koide A, Kaga T, Nakano S, Beppu F, Miyashita K. 2012. In vivo antioxidant activity of fucoxanthin on obese/diabetes KK-A y mice. Food Nutr. Sci., 3(11): 1491-1499
Jang SS, Shirai Y, Uchida M, Wakisaka M. 2012. Production of mono sugar from acid hydrolysis of seaweed. Afr. J. Biotechnol., 11(8): 1953-1963.
Jeon SM, Kim HJ, Woo MN, Lee MK, Shin YC, Park YB, Choi MS. 2010. Fucoxanthin‐rich seaweed extract suppresses body weight gain and improves lipid metabolism in high‐fat‐ fed C57BL/6J mice. Biotechnol. J., 5(9): 961-969.
Kadekaru T, Toyama H, Yasumoto T. 2008. Safety evaluation of fucoxanthin purified from Undaria pinnatifida. J. Jpn. Soc. Food Sci., 55 (6): 304-308.
Kim SK, Pangestuti R. 2011. 9 Biologica l activities and potential health benefits of fucoxanthin derived from marine brown algae. Adv. Food Nutr. Res., 64: 111.
Ley DH, Yamamoto R, Bickford AA. 1983. The pathogenesis of infectious bursal disease: serologic, histopathologic, and clinical chemical observations. Avian Dis. 27: 1060-1085. Matsuno T (2001). Aquatic animal carotenoids. Fish. Sci., 67: 771-783.
Miyashita K, Nishikawa S, Beppu F, Tsukui T, Abe M, Hosokawa M. 2011. The allenic carotenoid fucoxanthin, a novel marine nutraceutical from brown seaweeds. J. Sci. Food Agr., 91(7): 1166-1174.
Miyashita K, Mikami N, Hosokawa M. 2013. Chemical and nutritional characteristics of brown seaweed lipids: A review. J. Func. Foods,, 5(4): 1507-1517.
NRC. 1994. National research council. Nutrient requirements of poultry. 9th rev.ed. National Academy Press, Washington, DC. Okada T, Nakai M, Maeda H, Hosokawa M, Sashima T, Miyashita K. 2008. Suppressive effect of neoxanthin on the differentiation of 3T3-L1 adipose cells. J. Oleo Sci., 57(6): 345-351.
Quitain AT, Kai T, Sasaki M, Goto M. 2013. Supercritical carbon dioxide extraction of fucoxanthin from Undaria pinnatifida. J. Agr. Food Chem., 61(24): 5792-5797.
Panigrahy B, Rowe LD, Corrier DE. 1986. Haematological values and changes in blood chemistry in chickens with infectious bursal disease. Res. Vet. Sci., 40(1): 86-88. Park HJ, Lee MK, Park YB, Shin YC, Choi MS. 2011.
Beneficial effects of Undaria pinnatifida ethanol extract on diet-induced-insulin resistance in C57BL/6J mice. Food Chem. Toxicol., 49(4): 727-733.
Pérez-Gálvez A, Mínguez-Mosquera MI. 2005. Esterification of xanthophylls and its effect on chemical behavior and bioavailability of carotenoids in the human. Nutr. Res., 25(7): 631-640.
SPSS. 2011. Statistical packages for the social sciences, 20 ed. IBM Inc., Chicago. Stahl W, Sies H. 2005. Bioactivity and protective effects of natural carotenoids. BBA-Mol. Basis Disease., 1740(2): 101-107.
Synytsya A, Kim WJ, Kim SM, Pohl R, Synytsya A, Kvasnička F, Park YI. 2010. Structure and antitumour activity of fucoidan isolated from sporophyll of Korean brown seaweed Undaria pinnatifida. Carbohyd. Polym., 81(1): 41-48.
Woo MN, Jeon SM, Shin YC, Lee MK, Kang M, Choi MS. 2009. Anti‐obese property of fucoxanthin is partly mediated by altering lipid‐regulating enzymes and uncoupling proteins of visceral adipose tissue in mice. Mol. Nutr. Food Res., 53(12): 1603-1611.
Woo MN, Jeon SM, Kim HJ, Lee MK, Shin SK, Shin YC, Choi MS. 2010. Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice. Chem. Biol. Interact., 186(3): 316-322.
Yim MJ, Hosokawa M, Mizushina Y, Yoshida H, Saito Y, Miyashita K. 2011. Suppressive effects of amarouciaxanthin A on 3T3-L1 adipocyte differentiation through downregulation of PPARγ and C/EBPα mRNA expression. J. Agr. Food Chem., 59(5): 1646-1652.