Falah Saleh MOHAMMED, Eylem KINA, Mustafa SEVİNDİK, Muhittin DOĞAN, Mustafa PEHLİVAN

Datura stramonium (Solanaceae): Antioxidant and Antimicrobial Potentials

Many people in different parts of the world benefit from alternative medicine in the treatment and prevention of diseases. Plants are among the important natural materials used in alternative medicine. In this study, the antioxidant and antimicrobial potential of Datura stramonium L. was determined. Ethanol extracts of the plant's flower parts were obtained in the soxhlet device. The antioxidant and oxidant potential of the plant extract was determined using Rel Assay TAS and TOS kits. Antimicrobial activity was tested by the agar dilution method. The TAS value of the plant extract was 7.559±0.224 mmol/L, the TOS value was 10.711±0.243 μmol/L, and the OSI value was 0.142±0.002. It was determined that the plant extract was effective against bacteria and fungus strains at 100-400 μg/mL concentration. As a result, it was determined in our study that D. stramonium can be a natural antioxidant and antimicrobial source.

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Adebiyi OE, Olayemi FO, Ning-Hua T, Guang-Zhi Z. 2017. In vitro antioxidant activity, total phenolic and flavonoid contents of ethanol extract of stem and leaf of Grewia carpinifolia. Beni-Suef University Journal of Basic and Applied Sciences, 6(1): 10-14.

Arnao MB, Cano A, Acosta M. 1999. Methods to measure the antioxidant activity in plant material. A comparative discussion. Free Radical Research, 31(sup1): 89-96.

Barceloux DG. 2008. Medical toxicology of natural substances: foods, fungi, medicinal herbs, plants, and venomous animals. John Wiley & Sons. Bauer AW, Kirby WM, Sherris JC, Turck M. 1966. Antibiotic susceptibility testing by a standardized single disk method, Am J Clin Pathol, 45: 493-96.

Baynesagne S, Berhane N, Sendeku W, Ai L. 2017. Antibacterial activity of Datura stramonium against standard and clinical isolate pathogenic microorganisms. Journal of medicinal plants research, 11(31): 501-506.

Belayneh YM, Birhanu Z, Birru EM, Getenet G. 2019. Evaluation of in vivo antidiabetic, antidyslipidemic, and in vitro antioxidant activities of hydromethanolic root extract of Datura stramonium L. (Solanaceae). Journal of experimental Pharmacology, 11: 29.

Calixto JB, Scheidt C, Otuki M, Santos AR. 2001. Biological activity of plant extracts: novel analgesic drugs. Expert opinion on emerging drugs, 6(2): 261-279.

CLSI (The Clinical and Laboratory Standards Institute). 2012. Antimicrobial Susceptibility Testing of Anaerobic Bacteria; Approved Standard—Eighth Edition (M11-A8).

Culpeper N. 1995. Culpeper's complete herbal: A book of natural remedies for ancient ills. Wordsworth Editions.

Daştan SD, Durukan H, Demirbaş A, Dönmez E. 2019. Bioactivity and Therapeutic Properties of Evelik (Rumex crispus), A Naturally Growing and Edible Plant in Sivas Province. Turkish Journal of Agriculture - Food Science and Technology, 7(sp2): 67-71.

Davis PH. 1965. Flora of Turkey and the East Aegean Islands, Volume 6, Edinburgh University Press pp. 451

Deshmukh AS, Shelke PD, Palekar KS, Pawar SD, Hs S. 2015. Antimicrobial Investigation of Datura stramonium Leaf Extract against different Microorganisms. IOSR Journal of Environmental Science, Toxicology and Food Technology, 9(9):17-19.

Eftekhar F, Yousefzadi M, Tafakori V. 2005. Antimicrobial activity of Datura innoxia and Datura stramonium. Fitoterapia, 76(1): 118-120.

Erel O. 2004. A new automated colorimetric method for measuring total oxidant status. Clin biochem, 38(12): 1103-1111.

Erel O. 2005. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation, Clin biochem, 37(4): 277- 285.

EUCAST (European Committee on Antimicrobial Susceptibility Testing). 2014. Breakpoint tables Fungal isolate for interpretation of MICs. Version 7.0.

EUCAST (European Committee on Antimicrobial Susceptibility Testing). 2015. Breakpoint tables for Bacteria interpretation of MICs and zone diameters, Version 5.0.

Glatstein M, Alabdulrazzaq F, Scolnik D. 2016. Belladonna alkaloid intoxication: the 10-year experience of a large tertiary care pediatric hospital. American journal of therapeutics, 23(1): e74-e77.

Gul H, Qaisrani RN, Khan MA, Hassan S, Younis N. 2012. Antibacterial and antifungal activity of different extracts of Datura stramonium (branches and leaves sample). Journal of Biotechnology and Pharmaceutical Research, 3(9): 141-148.

Hindler J, Hochstein L, Howell A. 1992. Preparation of routine media and reagents used in antimicrobial susceptibility testing. Part 1. McFarland standards, p. 5.19.1-5.19.6. In H. D. Isenberg (ed) Clinical microbiology procedures handbook, vol. 1. American Society for Microbiology, Washington, D.C.

Iqbal S, Sivaraj C, Gunasekaran K. 2017. Antioxidant and Anticancer Activities of Methanol Extract of Seeds of Datura stramonium l. Free Radicals and Antioxidants, 7(2): 184-189.

Khan AK, Singh PD, Reese PB, Howden J, Thomas TT. 2019. Investigation of the anti-inflammatory and the analgesic effects of the extracts from Smilax ornata Lem. (Jamaican sarsaparilla) plant. Journal of ethnopharmacology, 240: 111830.

Krupodorova T, Sevindik M. 2020. Antioxidant potential and some mineral contents of wild edible mushroom Ramaria stricta. AgroLife Sci J, 9: 186-191.

Kumar PS, Sucheta S, Deepa VS, Selvamani P, Latha S. 2008. Antioxidant activity in some selected Indian medicinal plants. African Journal of Biotechnology, 7(12): 1826-1828

Lewis W. 1784. An Experimental History of the Materia Medica, Or of the Natural and Artificial Substances Made Use of in Medicine: Containing a Compendious View of Their Natural History, an Account of Their Pharmaceutic Properties and an Estimate of Their Medicinal Powers, J. Johnson & R. Baldwin.

Lichota A, Gwozdzinski K. 2018. Anticancer activity of natural compounds from plant and marine environment. International journal of molecular sciences, 19(11): 3533.

Lovett JV, Levitt J, Duffield AM, Smith NG. 1981. Allelopathic potential of Datura stramonium L.(Thorn‐apple). Weed Research, 21(3‐4): 165-170.

Makchuchit S, Rattarom R, Itharat A. 2017. The anti-allergic and anti-inflammatory effects of Benjakul extract (a Thai traditional medicine), its constituent plants and its some pure constituents using in vitro experiments. Biomedicine & Pharmacotherapy, 89: 1018-1026.

Matuschek E, Brown DF, Kahlmeter G. 2017. Development of the EUCAST disk diffusion antimicrobial susceptibility testing method and its implementation in routine microbiology laboratories, Clin Microbiol Infect, 20: 255- 266.

Miliauskas G, Venskutonis PR, Van Beek TA. 2004. Screening of radical scavenging activity ofsome medicinal and aromatic plant extracts. Food chemistry, 85(2): 231-237.

Mohammed FS, Akgul H, Sevindik M, Khaled BMT. 2018. Phenolic content and biological activities of Rhus coriaria var. zebaria. Fresen Environ Bull, 27(8): 5694-5702.

Mohammed FS, Günal S, Pehlivan M, Doğan M, Sevindik M, Akgül H. 2020. Phenolic content, antioxidant and antimicrobial potential of endemic Ferulago platycarpa. Gazi Univ J Sci, 33(4): 670-677.

Mohammed FS, Günal S, Şabik AE, Akgül H, Sevindik M. 2020. Antioxidant and Antimicrobial activity of Scorzonera papposa collected from Iraq and Turkey. Kahramanmaraş Sütçü İmam Univ Doğa Bilim Derg, 23(5): 1114-1118.

Mohammed FS, Karakaş M, Akgül H, Sevindik M. 2019. Medicinal properties of Allium calocephalum collected from Gara Mountain (Iraq), Fresen Environ Bull, 2019, 28(10): 7419-7426.

Pennacchio M, Jefferson L, Havens K. 2010. Uses and abuses of plant-derived smoke: Its ethnobotany as hallucinogen, perfume, incense, and medicine. Oxford University Press.

Salehi B, Gültekin-Özgüven M, Kirkin C, Özçelik B, MoraisBraga MFB, Carneiro JNP, Bezerra CF, da Silva TG, Coutinho HDM, Amina B, Armstrong L, Selamoglu Z, Sevindik M, Yousaf Z, Sharifi-Rad J, Muddathir AM, Devkota HP, Martorell M, Jugran AK, Cho W, Martins N. 2020. Antioxidant, antimicrobial, and anticancer effects of anacardium plants: an ethnopharmacological perspective, Front Endocrinol, 11: 295.

Salehi B, Gültekin-Özgüven M, Kırkın C, Özçelik B, MoraisBraga MFB, Carneiro JNP, Bezerra CF, da Silva TG, Coutinho HDM, Amina B, Armstrong L, Selamoglu Z, Sevindik M, Yousaf Z, Sharifi-Rad J, Muddathir AM, Devkota HP, Martorell M, Jugran AK, Martins N, Cho WC. 2019. Anacardium plants: chemical, nutritional composition and biotechnological applications, Biomolecules, 9(9): 465.

Salehi B, Selamoglu Z, Sevindik M, Fahmy NM, Al-Sayed E, ElShazly M, Csupor-Löffler B, Csupor D, Yazdi DE, SharifiRad J, Arserim-Uçar DK, Arserim EH, Karazhan N, Jahani A, Dey A, Azadi H, Vakili SA, Sharopov F, Martins N, Büsselberg D, Büsselberg D. 2020. Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications, Mol Cell Biol, 66(4): 78-103.

Saraç H, Demirbaş A, Daştan SD, Ataş M, Çevik Ö, Eruygur N. 2019. Evaluation of Nutrients and Biological Activities of Kenger (Gundellia tournefortii L.) Seeds Cultivated in Sivas Province. Turkish Journal of Agriculture - Food Science and Technology, 7(sp2): 52-58.

Schinella GR, Tournier HA, Prieto JM, De Buschiazzo PM, Rios JL. 2002. Antioxidant activity of anti-inflammatory plant extracts. Life sciences, 70(9): 1023-1033. Sevindik M, Akgul H, Pehlivan M, Selamoglu Z. 2017. Determination of therapeutic potential of Mentha longifolia ssp. longifolia, Fresen Environ Bull, 26(7): 4757-4763.

Sevindik M. 2020. Antioxidant and antimicrobial capacity of Lactifluus rugatus and its antiproliferative activity on A549 cells, Indian J Tradit Knowl, 19(2): 423-427.

Sevindik M. 2019. The novel biological tests on various extracts of Cerioporus varius, Fresen Environ Bull, 28(5): 3713-3717.

Sreenivasa S, Vinay K, Mohan NR. 2012. Phytochemical analysis, antibacterial and antioxidant activity of leaf extract of Datura stramonium. International Journal of Science Research, 1(2): 83-86.

Xiang J, Apea-Bah FB, Ndolo VU, Katundu MC, Beta T. 2019. Profile of phenolic compounds and antioxidant activity of finger millet varieties. Food chemistry, 275: 361-368.

Zazharskyi VV, Davydenko P, Kulishenko O, Borovik IV, Brygadyrenko VV. 2019. Antimicrobial activity of 50 plant extracts. Biosystems Diversity, 27(2): 163-169.