Osman Dönmez, Necla Yüce, Yeşim Özarda İlçöl, Bülent Ediz, Oğuzhan Durmaz, İftihar Kılıçbay

Sağlıklı çocuklarda idrar kalsiyum atılımı Orijinal Araştırma

Amaç: Hiperkalsiüri taramasında spot idrar kalsiyum kreatinin oranı pratik bir yöntemdir Bu çalışmada sağlıklı çocuklarda yaşlara göre spot idrar kalsiyum kreatinin oranı normal persantil değerlerini ve hiperkalsiüri yaygınlığını belirlemek istedik nbsp; Gereç ve Yöntem: Çalışmaya 614 çocuk alındı Olguların sabah ikinci idrar örnekleri toplandı ve kalsiyum kreatinin oranı mg mg olarak hesaplandı Olgular Grup 1 1 6 ay Grup 2 7 12 ay Grup 3 13 ay 2 yaş Grup 4 25 ay 6 yaş Grup 5 7 12 yaş ve Grup 6 13 16 yaş olmak üzere altı farklı gruba ayrılarak incelendi nbsp; Bulgular: Olgularımızın kalsiyum kreatinin oranları ortalama±SS Grup 1’de 0 33±0 10 Grup 2’de 0 23±0 06 Grup 3’de 0 15±0 08 Grup 4’de 0 13±0 08 Grup 5’de 0 09±0 07 Grup 6’da 0 08±0 07 saptandı Olgularımızın yaş ilişkili 95 persantil değerleri Grup 1’de 0 57 Grup 2’de 0 40 Grup 3’de 0 32 Grup 4’de 0 26 Grup 5’de 0 23 ve Grup 6’da 0 23 bulundu Bölgemizde hiperkalsiüri yaygınlığı 4 7 bulundu İdrar kalsiyum kreatinin oranı ile yaş ve vücut kitle indeksi arasında olumsuz yönlü ilişki gözlendi Çıkarımlar: İdrar kalsiyum kreatinin kaynak değerlerinin saptanmasında çocuğun yaşının 95 persantil değerlerinin ve coğrafik farklılıkların göz önünde bulundurulması sonucuna varılmıştır nbsp; Türk Ped Arş 2009; 44: 131 4 Anahtar kelimeler: Çocuk hiperkalsiüri idrar kalsiyum kreatinin oranı normal değerler persantil

Anahtar Kelimeler:

Çocuk, hiperkalsiüri, idrar kalsiyum kreatinin oranı, normal değerler, persantil

Urinary calcium excretion in healthy children Original Article

Aim: Measurement of calcium creatinine ratio in spot urine sample is a practical screening method for hypercalciuria This study aimed to identify age related reference percentile values for urinary calcium creatinine ratio in healthy children and to determine the frequency of hypercalciuria Material and Method: A total of 614 children were included Second morning urine samples were collected and calcium creatinine ratio mg mg was calculated Results were examined for the following six age groups: Group 1 1 6 months; Group 2 7 12 months; Group 3 13 months 2 years; Group 4 25 months 6 years; Group 5 7 12 years; and Group 6 13 16 years Results: The mean±SD values for calcium creatinine ratios of the age groups were as follows: Group 1 0 33±0 10; Group 2 0 23±0 06; Group 3 0 15±0 08; Group 4 0 13±0 08; Group 5 0 09±0 07; and Group 6 0 08±0 07 respectively Corresponding 95th percentile values for the age groups 1 to 6 were 0 57 0 40 0 32 0 26 0 23 and 0 23 respectively Hypercalciuria prevalence was found as 4 7 in our area Urinary calcium creatinine ratio was negatively correlated with age and body mass index Conclusions: Our findings suggest that age of the child 95th percentile values and geographical differences should be taken into account in detecting the reference values for urinary calcium creatinine ratio Turk Arch Ped 2009; 44: 131 4 Key words: Children hypercalciuria urinary calcium to creatinine ratio normal values percentilee

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Jones C, Mughal Z. Disorders of mineral metabolism and nephrolithiasis In: Webb NJA, Postlethwaite RJ, (eds). Clinical Pediatric Nephrology. New York: Oxford University Press, 2003: 89.
Milliner DS. Urolithiasis. In: Avner ED, Harmon WE, Niaudet P, (eds). Pediatric Nephrology. Philadelphia: Lippincott Williams&Wilkins, 2004: 1094-5.
Alon US, Berenbom A. Idiopathic hypercalciuria of childhood: 4-7 years outcome. Pediatr Nephrol 2000; 14: 1011-5. (Abstract) / (PDF)
Guignard JP, Santos F. Laboratory investigations. In: Avner ED, Harmon WE, Niaudet P, (eds). Pediatric Nephrology. Philadelphia: Lippincott Williams &Wilkins, 2004: 403.
Ghazali S, Barratt TM. Urinary excretion of calcium and magnesium in children. Arch Dis Child 1974; 49: 97-101. (Abstract) / (Full Text) / (PDF)
So NP, Osorio AV, Simon SD, Alon US. Normal urinary calcium /cre- atinine ratios in African-American and Caucasian children. Pediatr Nephrol 2001; 16: 133-9. (Abstract) / (PDF)
Mir S, Serdaroglu E. Quantification of hypercalciuria with the urine cal- cium osmolality ratio in children. Pediatr Nephrol 2005; 20: 1562-5. (Abstract) / (Full Text) / (PDF)
Alconcher LF, Castro C, Quintana D, Abt N, Moran L, Gonzalez L et al. Urinary calcium excretion in healthy school children. Pediatr Nephrol 1997; 11: 186-8. (Abstract) / (PDF)
Vachvanichsanong P, Lebel L, Moore ES. Urinary calcium excretion in healthy Thai children. Pediatr Nephrol 2000; 14: 847-50. (Abstract) / (PDF)
Esbjörner E, Jones IL. Urinary calcium excretion in Swedish chil- dren. Acta Pediatr 1995; 84:156-9. (Abstract) / (PDF)
Reusz GS, Dobos M, Byrd D, Sallay P, Miltényi M, Tulassay T. Urinary calcium and oxalate excretion in children. Pediatr Nephrol 1995; 9: 39-44. (Abstract) / (PDF)
Safarinejad MR. Urinary mineral excretion in healthy Iranian children. Pediatr Nephrol 2003; 18: 140-4.(Abstract) / (PDF)
Sönmez F, Akçanal B, Altincik A, Yenisey C. Urinary calcium excre- tion in healthy Turkish children. Int Urol Nephrol 2007; 39: 917-22. (Abstract) / (PDF)
Koyun M, Güven AG, Filiz S, et al. Screening for hypercalciuria in schoolchildren: what should be the criteria for diagnosis?. Pediatr Nephrol 2007; 22: 1297-301. (Abstract) / (Full Text) / (PDF)
Moore ES, Coe FL, McMann BJ, et al. Idiopathic hypercalciuria in children: prevalence and metabolic characteristics. J Pediatr 1978; 92: 906-10. (Abstract) / (PDF)
Sargent JD, Stukel TA, Kresel J, Klein RZ. Normal values for random urinary calcium to creatinine ratios in infancy. J Pediatr 1993; 131: 393-7. (Abstract) / (PDF)
Ceran O, Akin M, Aktürk Z, Ozkozaci T. Normal urinary calcium/creatinine ratios in Turkish children. Indian Pediatr 2003; 40: 884-7. (Abstract)
Matos V, van Melle G, Boulat O, Markert M, Bachmann C, Guignard JP. Urinary phosphate/creatinine, calcium/creatinine, and magne- sium/creatinine ratios in a healthy pediatric population. J Pediatr 1997; 131: 252-7. (Abstract) / (Full Text) / (PDF)
Kaneko K, Tsuchiya K, Kawamura R, et al. Low prevalence of hyper- calciuria in Japanese children. Nephron 2002; 91: 439-43. (Abstract) / (Full Text) / (PDF)
Kan İ. Biyoistatistik. ISBN:975-591-858-2. 4.Baskı. Bursa: Nobel Yayın Dağıtım, 2006: 89-91.
Kruse K, Kracht U, Kruse U. Reference values for urinary calcium excretion and screening for hypercalciuria in children and adoles- cents. Eur J Pediatr 1984; 143: 25-31. (Abstract) / (Full Text) / (PDF)
Sweid HA, Bagga A, Vaswani M, et al. Urinary excretion of minerals, oxalate, and uric acid in North Indian children. Pediatr Nephrol 1997; 11: 189-92. (Abstract)
Çalışkan S, Erkan T, Sever L, Arısoy N. İstanbul’da çocuklarda hiperkalsiüri taraması. Türk Ped Arş 1992: 27: 36-8. (Abstract) / (Full Text)
Rath B, Aggarwal MK, Mishra TK, Talukdar B, Murthy NS, Kabi BC. Urinary calcium creatinine ratio and hypercalciuria. Indian Pediatr 1994; 31: 311-6. (Abstract)
Sorkhi H, Haji Aahmadi M. Urinary calcium to creatinin ratio in chil- dren. Indian Pediatr 2005; 72: 1055-6. (Abstract) / (PDF)
Ersoy B, Ertan P, Uyanık BS, et al. Sağlıklı okul çocuklarında idiopatik hiperkalsiüri sıklığı. T Klin Pediatr 2002; 11: 6-9. (Abstract) / (PDF)
Berçem G, Cevit O, Toksoy HB, Içagasioglu D, Gültekin A, Tanzer F. Asymptomatic hypercalciuria: prevalence and metabolic charac- teristics. Indian J Pediatr 2001; 68: 315-8. (Abstract) / (PDF)