Coşkun YARAR, Arzu EKİCİ, Kürşat Bora ÇARMAN, Sevgi YİMENİCİOĞLU, Ayten YAKUT

Lennox-Gastaut sendromlu hastaların klinik özellikleri ve uzun süreli seyri

Amaç: Bu çalışmanın amacı Eskişehir Osmangazi Üniversitesi Çocuk Nörolojisi Bilim Dalı’nda Lennox-Gastaut sendromu tanısı ile izlenen 20 hastanın klinik özellikleri, tedavi ve seyrinin geriye dönük olarak değerlendirilmesidir. Gereç ve Yöntem: Lennox-Gastaut sendromu tanısı, birden fazla değişik nöbet tipi olması, elektroansefalogramda yaygın, yavaş (

Clinical evaluation and long term prognosis of patients with Lennox-Gastaut syndrome

Aim: The aim of this study was to retrospectively evaluate clinical features, treatment, prognosis of 20 patients followed up as Lennox-Gastaut Syndrome in Eskişehir Osmangazi University Pediatric Child Neurology department. Material and Method: Multiple different types of seizure, diffuse spike-wave pattern(

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1. Niedermeyer E. Lennox-Gastaut syndrome. Clinical description and diagnosis. Adv Exp Med Biol 2002; 497: 61-75.[Özet]
2. Gento P, Dravet C. Lennox-Gastaut syndrome. In: Engel, JR, Pedley TA, (eds). Epilepsy. A comprehensive textbook. Philadelphia: Wolters Kluver, Lippincott Williams and Wilkins, 2007: 2417-7.
3. Markand ON. Lennox-Gastauts syndrome (Childhood epileptic encephalopathy). J Clin Neurophysiol 2003; 20(6): 426-31. [Özet]
4. Stafstrom CE. Update on the management of Lennox-Gastaut syndrome with a focus on rufinamide. Neuropsychiatr Dis Treat 2009; 5: 547-51. [Özet]
5. Donat JF, Wright FS. Seizures in series: similarities between seizures of the West and Lennox-Gastaut syndromes. Epilepsia 1991; 32(4): 504-9.[Özet]
6. Montelli TC, Mota NG, Peracoli MT, Torres EA, Rezkallah-Iwasso MT. Immunological disturbance in West and Lennox Gastaut syndromes. Arq Neuropsiquiatr 1984; 42: 132-9. [Özet]
7. Crumrine PK. Lennox-Gastaut syndrome. J Child Neurol 2002; 17(Suppl 1): 70-5. [Özet]
8. Trevathan E, Murphy CC, Yeargin-Allsopp M. Prevalence and descriptive epidemiology of Lennox-Gastaut syndrome among Atlanta children. Epilepsia 1997; 38(12): 1283-8. [Özet]
9. van Rijckevorsel KV. Treatment of LGS: overview and recent findings. Neuropsychiatr Dis Treat 2008; 4(6): 1001-9. [Özet]
10. Goldsmith IL, Zupanc ML, Buchhalter JR. Long-term seizure outcome in 74 patients with Lennox-Gastaut syndrome: effects of incorporating MRI head imaging in defining the cryptogenic subgroup. Epilepsia 2000; 41(4): 395-9. [Özet]
11. Rantala H, Putkonen T. Occurence. Outcome and prognostic factors of infantile spasms and Lennox-Gastaut syndrome. Epilepsia 1999; 40: 286-7. [Özet]
12. You SJ, Kim HD, Kang HC. Factors influencing the evolution of West syndrome to Lennox-Gastaut syndrome. Pediatr Neurol 2009; 41(2): 111-3. [Özet]
13. Ogawa K, Kanemoto K, Ishii Y, et al. Long-term follow-up study of Lennox-Gastaut syndrome in patients with severe motor and intellectual disabilities: with special reference to the problem of dysphagia. Seizure 2001; 10(3): 197-202. [Özet]
14. Çalışkan M, Yılmaz Y, Aydınlı N, Özmen M. Altmış sekiz Lennox-Gastaut sendromu vakasının özellikleri. Çocuk Sağlığı ve Hastalıkları Dergisi 1997; 40: 79-84.
15. Berg AT, Plioplys S, Tuchman R. Risk and correlates of autism spectrum disorder in children with epilepsy: a community-based study. J Child Neurol 2011; 26(5): 540-7. [Özet]
16. Hançerli S, Çalışkan M, Mukaddes NM, Tatlı B, Özmen M. West sendromunda otistik bozukluk. Turk Ped Arş 2011; 46: 68-74. [Özet]
17. Ohtsuka Y, Amano R, Mizukawa M, Ohtahara S. Long-term prognosis of the Lennox-Gastaut syndrome. Jpn J Psychiatry Neurol 1990; 44(2): 257-64. [Özet]
18. Ferrie CD, Patel A. Treatment of Lennox-Gastaut Syndrome (LGS). Eur J Paediatr Neurol 2009; 13(6): 493-504. [Özet]
19. Motte J, Trevathan E, Arvidsson JF, Barrera MN, Mullens EL, Manasco P. Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome. Lamictal Lennox-Gastaut Study Group. N Engl J Med 1997; 337(25): 1807-2.
20. Sachdeo RC, Glauser TA, Ritter F, Reife R, Lim P, Pledger G. A double-blind, randomized trial of topiramate in Lennox-Gastaut syndrome. Topiramate YL Study Group. Neurology 1999; 52(9): 1882-7.
21. Schmidt D, Bourgeois B. A risk-benefit assessment of therapies for Lennox-Gastaut syndrome. Drug Saf 2000; 22(6): 467-7. [Özet]
22. Conry JA, Ng YT, Paolicchi JM, et al. Clobazam in the treatment of Lennox-Gastaut syndrome. Epilepsia 2009; 50(5): 1158-66. [Özet]
23. Ng Y, Collins SD. Clobazam. Neurotherapeutics 2007; 4(1): 138-44. [Özet] 24. Illum N, Taudorf K, Heilmann C, et al. Intravenous immunoglobulin: a single-blind trial in children with Lennox-Gastaut syndrome. Neuropediatrics 1990; 21(2): 87-90. [Özet]
25. Autry AR, Trevathan E, Van Naarden Braun K, Yeargin-Allsopp M. Increased risk of death among children with Lennox-Gastaut syndrome and infantile spasms. J Child Neurol 2010; 25(4): 441-7.[Özet]