Melda ÇELİK, Aslınur PARLAKAY ÖZKAYA, Ateş KARA, Mehmet CEYHAN, Ali Bülent CENGİZ

Üç olgu nedeniyle perinatal HİV ve koruma

Kazanılmış immün yetersizlik virüsü (HİV) , 1981 yılında salgının başlamasından bu yana tüm dünya genelinde yaklaşık olarak 60 milyon kişiyi enfekte etmiş, 25 milyon kişinin ölümüne neden olmuştur. Yaklaşık olarak 430 000 (240 000-610 000) çocuk 2008 yılında, HİV’li olarak doğmuş ve dolayısıyla 15 yaşın altındaki HİV ile enfekte çocuk sayısı 2,1 milyona (1,2 -2,9 milyon) yükselmiştir. Perinatal yolla yayılım çocukluk çağındaki AİDS olgularının %90’ından ve çocukluk çağındaki yeni AİDS olgularının neredeyse tamamından sorumludur. Bu olgu sunumunda HİV pozitif anneden doğan üç bebeğin klinik seyirleri özetlenerek perinatal HİV yayılımının seyri ile ilgili son literatür gelişmelerine değinilmiştir.

Perinatal HIV and prophylaxis: Case reports

After the onset of epidemics in 1981, acquired immunodeficiency virus (HIV) has approximately infected 60 million people and caused death of 25 million people. In 2008, nearly 430 000 (240 000-610 000) children was born as infected with HIV and so the number of HIV infected children under 15 years of age was increased to 2.1 million (1.2 -2.9 million). Perinatal transmission is responsible for AIDS in 90% of children and nearly all new AIDS cases in children are caused by perinatal transmission. In this case report, clinical pictures of 3 babies born to HIV positive mothers are mentioned with the recent updates of literature concerning HIV.

PDF

___

1. UNAIDS 2009 AIDS epidemic update. http://data.unaids.org/pub/ FactSheet/ 2009/20091124_FS_global_en.pdf. [Özet]
2. Sağlık Bakanlığı HIV/AIDS verileri 2010. http://pozitifyasam.org/ assets/files/Aralik2010verileri.htm
3. UNGRASS indicators country report. http://data.unaids.org/ pub/Report/ 2008/turkey_2008_country_progress_report_en.pdf
4. Lindsay MK, Grant J, Peterson HB, Willis S, Nelson P, Klein L. The impact of knowledge of human immunodeficiency virus serostatus on contraceptive choice and repeat pregnancy. Obstet Gynecol 1995; 85: 675-9. [Özet]
5. Cooper ER, Charurat M, Mofenson L, et al. Women and infants' transmission study. Group combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission. J Acquir Immune Defic Syndr 2002; 29: 484-94.[Özet]
6. Nduati R, Mbori-Ngacha D, John G, et al. Breastfeeding in women with HIV. JAMA 2000;284: 956-7.
7. Connor EM, Sperling RS, Gelber R, et al. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med 1994; 331: 1173-80. [Özet]
8. Mofenson LM. Technical report: perinatal human immunodeficiency virus testing and prevention of transmission. Committee on Pediatric Aids. Pediatrics 2000; 106: E88. [Özet]
9. Wade NA, Birkhead GS, Warren BL, et al. Abbreviated regimens of zidovudine prophylaxis and perinatal transmission of the human immunodeficiency virus. N Engl J Med 1998;339: 1409-14. [Özet]
10. El-Sadr W, Oleske JM, Agins BD. Managing early HIV infection. Agency for health care policy and research. Clin Pract Guidel Quick Ref Guide Clin 1994;7: 1-37. [Özet]
11. Borkowsky W, Krasinski K, Paul D, Moore T, Bebenroth D, Chandwani S. Human-immunodeficiency-virus infections in infants negative for anti-HIV by enzyme-linked immunoassay. Lancet 1987;1: 1168-71. [Özet]
12. Hanson IC, Shearer WT. Diagnosis of HIV infection. Semin Pediatr Infect Dis 1994; 5: 266-71.
13. Working group on antiretroviral therapy: National pediatric HIV resource center. Antiretroviral therapy and medical management of the human immunodeficiency virus-infected child. Pediatr Infect Dis J 1993;12: 513-22.
14. Hanson IC, Antonelli TA, Sperling RS, et al. Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine. J Acquir Immune Defic Syndr Hum Retrovirol 1999; 20: 463-7. [Özet]
15. Havens PL, Mofenson LM, American Academy of Pediatrics Committee on Pediatric AIDS. Evaluation and management of the infant exposed to HIV-1 in the United States. Pediatrics 2009;123: 175-87.[Özet]