Kist hidatikli çocuk olguların on yıllık izlemi

Amaç: Kist hidatik dünyada yaygın görülen endemik bir parazitik hastalıktır. Çalışmamızda kist hidatikli çocuk hastaların verilerinin gözden geçirilmesi, hastalık bulguları ve verilen tedaviler ile tedavi yanıtının değerlendirilmesi, tedavi yanıtını etkileyen etmenlerin saptanması amaçlanmıştır. Gereç ve Yöntemler: Ocak 2006 ve Aralık 2016 yılları arasında kist hidatik nedeniyle izlemde olan hastaların dosyaları gözden geçirildi. Hastaların tanı yaşları, cinsiyetleri, yaşam alanları (kırsal/kent), köpek temas öyküsü, ailede başka bireylerde kist hidatik varlığı, yakınmaları, tutulan organları, boyutları, laboratuvar sonuçları, uygulanan tedaviler ve tedavi sonrası yanıtları kayıt edildi. Bulgular: On yıllık sürede 50 çocuk hasta kist hidatik tanısı ile izlendi. Hastaların 33’ü (%66) erkekti. Ortalama tanı yaşı 9,3±0,5 yıldı. Hastaların 15’i kırsal kesimde yaşarken; 35’i kentsel kesimde yaşıyordu ve %10’unda ailede başka bireyde kist hidatik öyküsü vardı. Hastaların 36’sında akciğer tutulumu, 25’inde karaciğer tutulumu vardı. On dört hastada hem akciğer hem karaciğer tutulmuştu. Altı hastada akciğer ve karaciğer dışı organ tutulumu vardı. Kist hidatik indirekt hemaglutinasyon testi bakılan hastaların %60’ında pozitif iken, kist hidatik spesifik IgE 17 hastanın 8’inde pozitif saptandı. Hastaların tümü albendazol tedavisi almıştı. Yedi hastaya ek olarak praziquantel tedavisi verilmişti. Akciğer tutulumu olan 31 hastaya cerrahi, karaciğer tutulumu olan 13 hastaya PAİR (perkütan aspirasyon, enjeksiyon ve reaspirasyon) yapılmıştı. Spinal tutulumu olan iki hastada operasyonla kistler çıkarılmıştı. Akciğer ve karaciğer dışı organ tutulumu olan hastalarda yineleme sıklığı fazlaydı (p

Ten-year follow-up of children with hydatid cysts

Aim: Hydatid cystic disease is an endemic parasitic disease that is common in the world. We aimed to review the demographic, clinical and laboratory findings, and treatments and outcomes of children with hydatid cyst disease, and to determine the factors affecting treatment response in two pediatric pulmonology centers in the central region of Turkey. Material and Methods: The clinical records of patients aged below 18 years who were followed up between January 2006 and December 2016 because of hydatid cyst disease were reviewed retrospectively. The patients’ ages at the time of diagnosis, sexes, living areas (rural / urban), dog contact history, presence of hydatid cyst in other family members, symptoms, organs involved, dimensions of cysts, laboratory results, treatments and post treatment responses, follow-up, and outcomes were noted. Results: In a period of 10 years, 50 pediatric patients were followed up with a diagnosis of hydatid cyst. The mean age was 9.3±0.5 years and 33 (66%) of the patients were male. Fifteen patients were living in a rural area and 35 were living in an urban area. Fifteen patients had a history of contact with a dog and 10% had a positive family history. Thirty-six patients had lung involvement, 25 had liver involvement, 14 (28%) had both lung and liver involvement, and six patients had organ involvement other than lung and liver. The indirect hemagglutination test for hydatid cyst was positive in 24 of 40 patients and Echinococcus granulosus -specific IgE positivity was detected in 8 of 17 patients. Surgery was performed in 31 patients with lung involvement and PAIR was performed in 13 patients who had liver involvement. Cyst excision was performed in two patients who had isolated spinal involvement. All patients were treated with albendazole, and additional praziquantel treatment was given to seven patients. Relapse occurred in seven patients in this period. The relapse frequency was higher in patients who had organ involvement other than in the lung and liver (p

___

  • 1. Kuzucu A, Ulutas H, Reha Celik M, Yekeler E. Hydatid cysts of the lung: lesion size in relation to clinical presentation and therapeutic approach. Surg Today 2014; 44: 131−6.
  • 2. Koca T, Dereci S, Gençer A, et al. Cystic echinococcosis in childhood: Five-years of experience from a single-center. Turkiye Parazitol Derg 2016; 40: 26−31. [CrossRef]
  • 3. Anadol D, Gocmen A, Kiper N, Ozcelik U. Hydatid disease in childhood: a retrospective analysis of 376 cases. Pediatr Pulmonol 1998; 26: 190−6. [CrossRef]
  • 4. Ben Brahim M, Nouri A, Ksia A, et al. Management of multiple echinococcosis in childhood with albendazole and surgery. J Pediatr Surg 2008; 43: 2024−30. [CrossRef]
  • 5. Brunetti E, Kern P, Vuitton DA; Writing Panel for the WHO-IWGE. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop 2010; 114: 1−16. [CrossRef]
  • 6. Giorgio A, de Stefano G, Esposito V, et al. Long-term results of percutaneous treatment of hydatid liver cysts: a single center 17 years’ experience. Infection 2008; 36: 256−61.
  • 7. Turkyilmaz Z, Sonmez K, Karabulut R, et al. Conservative surgery for treatment of hydatid cysts in children. World J Surg 2004; 28: 597−601. [CrossRef]
  • 8. Abbas M, Nafeh AI, Youssef YF, Nasr MM, Radwan HS. Conservative versus radical surgery for treatment of uncomplicated hepatic hydatid cysts. J Egypt Soc Parasitol 2006; 36: 559−76.
  • 9. Ammann RW, Eckert J. Cestodes. Echinococcus. Gastroen terol Clin North Am 1996; 25: 655−89. [CrossRef]
  • 10. Sayek I, Tirnaksiz MB, Dogan R. Cystic hydatid disease: current trends in diagnosis and management. Surg Today 2004; 34: 987−96. [CrossRef]
  • 11. Gun E, Etit D, Buyuktalanci DO, Cakalagaoglu F. Unusual locations of hydatid disease: A 10-year experience from a tertiary reference center in Western Turkey. Ann Diagn Pathol 2017; 29: 37−40. [CrossRef]
  • 12. Santivanez S, Garcia HH. Pulmonary cystic echinococcosis. Curr Opin Pulm Med 2010; 16: 257−61. [CrossRef]
  • 13. Morar R, Feldman C. Pulmonary echinococcosis. Eur Respir J 2003; 21: 1069−77. [CrossRef]
  • 14. Lucas SB. Other viral and infectious diseases and HIV-related liver disease. In: RNM MacSween, Burt A, Portmann B, Ferrell L, editors. Pathology of the Liver. London Churchill Livingstone; 2012. p. 437−8. [CrossRef]
  • 15. Kulacoglu IH, Oruc MT, Kocaerkek Z, Seckin S, Coskun F. Unusual locations of hydatid disease: an evaluation of 77 cases. Turk J Gastroenterol 2001; 12: 299−302.
  • 16. Bellil S, Limaiem F, Bellil K, et al. Descriptive epidemiology of extrapulmonary hydatid cysts: a report of 265 Tunisian cases. [Article in French] Tunis Med 2009; 87: 123−6.
  • 17. Geramizadeh B. Unusual locations of the hydatid cyst: a review from Iran. Iran J Med Sci 2013; 38: 2−14.
  • 18. Padayachy LC, Dattatraya M. Hydatid disease (Echinococcus) of the central nervous system. Childs Nerv Syst 2018; 34: 1967−71. [CrossRef]
  • 19. Dogan I, Kahilogullari G, Guner E, Unlu A. A rare and unexpected clinical progress and location on a primary extradural spinal hydatid cyst in a pediatric patient: a case report. Childs Nerv Syst 2015; 31: 1407−11. [CrossRef]
  • 20. Dagtekin A, Koseoglu A, Kara E, et al. Unusual location of hydatid cysts in pediatric patients. Pediatr Neurosurg 2009; 45: 379−83. [CrossRef]
  • 21. Midyat L, Gökçe S, Onder A, Ozdemir Y, Mursalov G, Mir S. A very rare cause of childhood paraparesis: primary intradural extramedullary spinal hydatid cyst. Pediatr Infect Dis J 2009; 28: 754−5. [CrossRef]
  • 22. Eloqayli H, Matalka I, Daoud S. Primary spinal extradural hydatid cyst in a 4-year-old child. Br J Neurosurg 2010; 24: 602−3. [CrossRef]
  • 23. Limaiem F, Bellil S, Bellil K, et al. Primary hydatidosis of the central nervous system: a retrospective study of 39 Tunisian cases. Clin Neurol Neurosurg 2010; 112: 23−8.
  • 24. Zarzosa MP, Orduña Domingo A, Gutiérrez P, et al. Evaluation of six serological tests in diagnosis and postoperative control of pulmonary hydatid disease patients. Diagn Microbiol Infect Dis 1999; 35: 255−62. [CrossRef]
  • 25. Force L, Torres JM, Carrillo A, Buscà J. Evaluation of eight serological tests in the diagnosis of human echinococcosis and follow-up. Clin Infect Dis 1992; 15: 473−80. [CrossRef]
  • 26. Babba H, Messedi A, Masmoudi S, et al. Diagnosis of human hydatidosis: comparison between imagery and six serologic techniques. Am J Trop Med Hyg 1994; 50: 64−8.
  • 27. Petropoulos AS, Chatzoulis GA. Echinococcus granulosus in childhood: A retrospective study of 187 cases and newer data. Clin Pediatr (Phila) 2019; 58: 864−88. [CrossRef]
  • 28. Onal O, Demir OF. Is anatomic lung resection necessary in the surgical treatment of giant lung hydatid cysts in childhood? Ann Thorac Cardiovasc Surg 2017; 23: 286−90.
  • 29. Moro PL. Treatment of echinococcosis. Available from: https://www.uptodate. com/contents/treatment-of-echin ococcosis?topicRef=3588&source=see_link. Accessed at 17/07/2018.
  • 30. Çakır M, Balasar M, Küçükkartallar T, et al. Management of extra hepatopulmonary hydatid cysts (157 cases). Turkiye Parazitol Derg 2016; 40: 72−6. [CrossRef]
  • 31. Velasco-Tirado V, Romero-Alegría Á, Belhassen-García M, et al. Recurrence of cystic echinococcosis in an endemic area: a retrospective study. BMC Infect Dis 2017; 17: 455.
  • 32. Schipper HG, Koopmans RP, Nagy J, Butter JJ, Kager PA, van Boxtel CJ. Effect of dose increase or cimetidine co-administration on albendazole bioavailability. Am J Trop Med Hyg 2000; 63: 270−3. [CrossRef]
  • 33. Rigter IM, Schipper HG, Koopmans RP, et al. Relative bioavailability of three newly developed albendazole formulations: a randomized crossover study with healthy volunteers. Antimicrob Agents Chemother 2004; 48: 1051−4. [CrossRef]
Türk Pediatri Arşivi-Cover
  • ISSN: 1306-0015
  • Başlangıç: 2015
  • Yayıncı: Alpay Azap
Sayıdaki Diğer Makaleler

Bir çocukta birincil posterior mediastinal germ hücreli tümör

Theodotis PAPAGEORGİOU, Emmanuel HATZİPANTELİS, Tatiana SOULTANA TZİOLA, Ioannis SPYRİDAKİS, Athanasios TRAGİANNİDİS, Anastasia GKAMPETA

Kist hidatikli çocuk olguların on yıllık izlemi

Sevgi PEKCAN, Tuğba ŞİŞMANLAR EYÜBOĞLU, Tuğba RAMASLI GÜRSOY, Ayşe TANA ASLAN, Işıl İrem BUDAKOĞLU

Birincil kist hidatiğin alışılmadık lokalizasyonu ve birlikteliği: olgu sunumu

Canan KOCAOĞLU, Ayşe YAVUZ, Aslan AKIN, Çelebi KOCAOĞLU

Yunanlı ergenlerde patolojik kumar oynama ve eş zamanlı duygusal/davranışsal sorunlar

Charalampos PAPAGEORGİOU, Helen LAZARATOU, Marina ECONOMOU, Melpomeni MALLİORİ, Dimitris ANAGNOSTOPOULOS, Assimina PALEOLOGOU, George PAPADİMİTRİOU

Brakiyal pleksopatinin nadir bir nedeni: herediter nevraljik amiyotrofi

Hepsen Mine SERİN, Erdem ŞİMŞEK, Gül AKTAN, Sanem YILMAZ, Sarenur GÖKBEN, Hasan TEKGÜL, Seda KANMAZ

Çocuklarda Behçet hastalığı: tek merkez deneyimi

Murat Soner ÇİRKİNOĞLU, Selcan DEMİR, Seza ÖZEN, Yelda BİLGİNER

Lise öğrencilerinde obezite gelişimini etkileyen risk etmenleri

Viroj WİWANİTKİT, Sora YASRİ

Malnütrisyonlu çocuklarda kardiyak değerlendirme

Muhittin ÇELİK, Nezir ÖZGÜN, Osman AKDENİZ, Erdal YILMAZ

Çocuklarda sindirim sistemi hastalıklarının tanı ve izleminde dışkı incelemelerinin yeri

Erhun KASIRGA

Annelerin 0–6 yaş çocuklar için ev kazalarına karşı aldıkları önlemlerin değerlendirilmesi

Zehra ASLAN AYDOĞDU, Elif ATEŞ, Turan SET