Cuma TAŞIN, Gülnur ÖZAKŞİT

3916

İntrauterin İnseminasyon Uygulanan Hastalarda Sperm Parametrelerinin Gebelik Sonuçları ile İlişkisi

Amaç: İnfertil hastalarda intrauterin inseminasyon yaygın kullanılan bir yöntemdir. Bu hastalardaki gebelik başarısınıetkileyen sperm parametreleri ise hala tartışmalı bir konudur. Bu çalışmamız sperm parametrelerinin intrauterininseminasyon sonuçlarına etkisini tayin etmeyi amaçlamaktadır.Gereç ve Yöntem: Çalışmamız Ocak 2009-Ocak 2011 tarihleri arasında Dr. Zekai Tahir Burak Kadın Sağlığı Eğitim ve AraştırmaHastanesi infertilite polikliniğinde rekombinant FSH ile ovulasyon indüksiyonu oluşturulup intrauterin inseminasyonuygulanan 170 infertil hastanın 300 siklusunun incelendiği bir çalışmadır. Yaş, bazal FSH, toplam kullanılan FSH dozu,tedavi siklus sayısı, sigara kullanımı, varikosel ve semen parametreleri ile tedavi sonuçları karşılaştırıldı. Hastaların semenparametrelerinde total progresif motil sperm sayısı ≤10 milyon ve >10 milyon , morfoloji ise ≤ % 4 ve >% 4 olarak gruplaraayrıldı. Total progresif motil sperm sayısı ve morfoloji gruplarının gebelik sonuçlarına bakıldı. Erkek hastalarda sigarakullanımı ve varikoselin total progresif motil sperm sayısı ve morfolojiye olan etkilerine bakıldı.Bulgular: Total progresif motil sperm sayısı <10 milyon ve ≥10 milyon grupları arasında ve morfoloji ≤% 4 ve >% 4grupları arasında klinik gebelik oranları açısından istatiksel olarak anlamlı fark saptanmadı. Erkelerde sigara kullanımınınnormal morfolojideki sperm sayısının azalttığı, varikoselin ise hem total progresif motil sperm sayısını hem de normalmorfolojideki sperm sayısının azalttığı bulundu.Sonuç: İntrauterin inseminasyon sikluslarındaki gebelik oranları ne tek başına morfoloji ne de tek başına total progresifmotil sperm sayısı ile korelasyon göstermektedir. İnfertil erkeklerde sigara kullanımının özellikle morfolojiyi bozarakgebelik oranlarını azalttığı saptandı. Varikoselin hem morfolojiyi hem de total progresif motil sperm sayısını azalttığıfakat bunun gebelik sonuçlarını etkilemediği sonucuna ulaşıldı.
Anahtar Kelimeler:

intrauterin inseminasyon, sperm parametreleri, Total progresif motil sperm sayısı, morfoloji

The Relationship Between Sperm Parameters and Pregnancy Outcomes in Patients Undergoing Intra Uterine Insemination

Aim: Intrauterine insemination is a widely used method in infertile patients. Sperm parameters that affect pregnancysuccess in these patients are still a problematic issue. This study aims to determine the effect of sperm parameters onintrauterine insemination results.Material and Method: In this study; 300 cycles of 170 infertile patients who underwent intrauterine insemination afterovulation induction with recombinant FSH in the infertility outpatient clinic of the Dr. Zekai Tahir Burak Women's HealthTraining and Research Hospital between January 2009 and January 2011 were examined. Age, basal FSH, total FSHdose used, number of treatment cycles, smoking, varicocele, semen parameters and treatment results were compared.Patients were divided into groups as Total progressive motile sperm count ≤10 million and >10 million, morphology ≤4%and morphology >4% in semen parameters. Pregnancy results of total progressive motile sperm count and morphologygroups were analyzed. In male patients, the effects of smoking and varicocele on total progressive motile sperm countand morphology from sperm parameters were evaluated.Results: No statistically significant difference was found between the total progressive motile sperm count ≤10 millionand total progressive motile sperm count >10 million groups and between the morphology≤4% and morphology>4%groups in terms of clinical pregnancy rates. It was found that smoking in men decreased morphology, while varicoceledecreased both total progressive motile sperm count and morphology.Conclusion: Pregnancy rates in intrauterine insemination cycles show no correlation with either morphology alone ortotal progressive motile sperm count alone. It was found that smoking in infertile men decreased pregnancy rates byparticularly disrupting the morphology. It was concluded that varicocele reduces both morphology and total progressivemotile sperm count in male patients, but this does not affect pregnancy outcomes.
Keywords:

Intrauterine insemination; sperm parameters; total progressive motile sperm count; morphology,

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Türk Kadın Sağlığı ve Neonatoloji Dergisi-Cover
  • Başlangıç: 2019
  • Yayıncı: Sağlık Bilimleri Üniversitesi Etlik Zübeyde Hanım Kadın Hastalıkları Eğitim ve Araştırma Hastanesi
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