Asemptomatik gebe kadınlarda COVID-19 taraması: Hangisi daha iyi; rektal mi orofaringeal / nazofaringeal sürüntü mü?
Amaç: Çalışmanın amacı, rektal ve orofaringeal / nazofaringeal sürüntü ile gebelerde asemptomatik COVID-19 hastalıkinsidansını değerlendirerek iki yöntemin etkinliğini karşılaştırmaktı.Gereç ve Yöntem: Bu prospektif kohort çalışmasına, Ankara'da üçüncü basamak bir merkezin obstetri ünitesinde 7Mayıs-24 Eylül 2020 tarihleri arasında planlı sezaryen yapılan 234 asemptomatik gebe dahil edildi. Tüm katılımcılardanorofaringeal / nazofaringeal sürüntü, rektal sürüntü, plasental, amniyotik sıvı ve kordon kanı örnekleri alındı. Orofaringeal/ nazofaringeal veya rektal örneklerden herhangi biri pozitif olduğunda plasental, amniyotik sıvı ve kordon kanı örnekleritest edildi. Örneklerdeki SARS-CoV-2 virüsünü tespit etmek için gerçek zamanlı ters transkriptaz-polimeraz zincirreaksiyonu (RT-PCR) testi yapıldı.Bulgular: Asemptomatik COVID-19 hastalık insidansı çalışma popülasyonunda % 0,42 (1/234) idi. 234 orofaringeal /nazofaringeal sürüntüden biri pozitif iken, orofaringeal / nazofaringeal sürüntü ile pozitif olan dahil rektal sürüntülerinhiçbiri SARS-CoV-2 virüsü için pozitif değildi. COVID pozitif olgunun plasental, amniyotik sıvı ve kordon kanı örneklerininRT-PCR testi sonuçları negatifti.Sonuç: Ankara'da elektif sezaryen ile doğum yapmış gebelerde asemptomatik COVID-19 hastalığı insidansı düşüktü.Asemptomatik hamile kadınlarda, orofaringeal / nazofaringeal sürüntü rektal sürüntü ile karşılaştırıldığında COVID-19hastalığını tespit etmede daha yararlı bulundu. Asemptomatik hastalığın intrauterin geçişine dair bir kanıt bulunamadı.
Anahtar Kelimeler:
COVID-19, SARS-CoV-2, koronavirüs, gebelik, orofaringeal / nazofaringeal sürüntü, rektal sürüntü
Screening for COVID-19 in asymptomatic pregnant women: Which is better; rectal or oropharyngeal/nasopharyngeal swab?
Aim: The aim of the study was to evaluate the incidence of asymptomatic COVID-19 disease in pregnant women withrectal and oropharyngeal/nasopharyngeal swab to compare the efficacy of two samples.Material and Method: This prospective cohort study included 234 asymptomatic pregnant women who had undergoneplanned cesarean section between May 7 and September 24, 2020 in obstetrics unit of a tertiary care center, in Ankara,Turkey. The oropharyngeal/nasopharyngeal swab, rectal swab, placental, amniotic fluid, and cord blood samples wereobtained from all participants. The placental, amniotic fluid, and cord blood samples were tested when any of theoropharyngeal/nasopharyngeal or rectal samples were positive. The real-time reverse transcriptase-polymerase chainreaction (RT-PCR) test was performed to detect SARS-CoV-2 virus in the samples.Results: The incidence of the asymptomatic COVID-19 disease was 0.42% (1/234) in the study population. One of 234oropharyngeal/nasopharyngeal swabs was positive, while none of the rectal swabs including the one positive withoropharyngeal/nasopharyngeal swab were positive for SARS-CoV-2 virus. The RT-PCR test results of the placental,amniotic fluid, and cord blood samples of the COVID-positive case were negative.Conclusion: The incidence of asymptomatic COVID-19 disease in pregnant women who had undergone elective cesareandelivery was low, in Ankara, Turkey. In asymptomatic pregnant women, oropharyngeal/nasopharyngeal swab was foundto be more useful in detecting COVID-19 disease compared to rectal swab. No evidence was found about the intrauterinetransmission of asymptomatic disease.
Keywords:
COVID-19, SARS-CoV-2, coronavirus, pregnancy, oropharyngeal/nasopharyngeal swab, rectal swab,
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- Başlangıç: 2019
- Yayıncı: Sağlık Bilimleri Üniversitesi Etlik Zübeyde Hanım Kadın Hastalıkları Eğitim ve Araştırma Hastanesi
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