Tartrazinin Fare Dermal Mast Hücrelerinde Degranülasyon Etkisi

Bu çalışmada enjeksiyon yolu ile verilen tartrazinin E-102 fare Mus musculus domesticus dermal masthücreleri üzerindeki degranülasyon etkisi transmisyon elektron mikroskobu ile incelenmiştir. Tartrazinin deri altınaenjeksiyonundan 1, 6, 12 ve 24 saat sonra dermal mast hücrelerindeki degranülasyon etkisi incelenmiştir. Tartrazinenjeksiyonundan 1 ve 12 saat sonra mast hücrelerinde kısmi degranülasyon meydana geldiği halde, 6 saat sonraoldukça fazla iç degranülasyon gözlenmiştir. Enjeksiyondan 24 saat sonra ise çok belirgin bir degranülasyon tespitedilememiştir

Anahtar Kelimeler:

Mast hücresi, degranülasyon, tartrazin

Degranulation Effect Of Tartrazine On The Dermal Mast Cells Of Mouse

In this study degranulation effects of intradermally injected tartrazine E-102 on the dermal mast cells of mouse Mus musculus domesticus have been studied by transmission electron microscope. Examination of thedegranulation have been carried out 1, 6, 12 and 24 hours after the intradermal injection of the tartrazine. Tartrazinehas been found to cause a partial degranulation after 1 hour and 12 hours from the injection. However, at the endof the 6 hours period an internal degranulation was predominant. Apperence of the degranulation has virtuallydissapeared after 24 hours

Keywords:

Mast cell, degranulation, tartrazine,

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Reynolds JE. Martindale, The extra pharmacopoeia, Thirtieth edition, London: The Pharmaceutical Press, 1993: and 1132-1133.
Selinger B. Chemistry in the market place. London: John Murray Publishers Ltd., 1980: 312 and 354-360.
Resmi Gazete. Tarım ve Köyişleri Bakanlığından: Türk Gıda Kodeksi Yönetmeliği, Sayı: 23172, 16 Kasım 1997.
Pollock I, Young E, Stoneham M, Slater N, Wilkinson JD. Warner JO. Survery of colouring and preservatives in drugs. Br Med J 1989; 299: 649-51.
Weber RW. Food additives and allergy. Ann Allergy 1993; 70: 183-190.
Kolly M, Pécoud A. Frei PC. Additives contained in drug formulations most frequently prescribed in Switzerland. Ann Allergy 1989;62: 21-25.
Collins-Williams C. Intolerance to additives. Ann Allerg 1983; 51: 315-316.
Moneret-Vautrin DA. Food antigens and additives. J Allergy Clin Immunol 1986; 78: 1039-1046.
Smith JM. Allergic reactions to drug excipients. Practitioner 1987; 231: 579-683.
Juhlin L, Michaëlsson G, Zetterström O. Urticaria and asthma induced by food and drug additives in patients with aspirin hypersensivity. J Allergy Clin Immunol 1972;50(2): 92-98.
Juhlin L. Recurrent urticaria: clinical investigation of 330 patients. Br J Dermatol, 1981; 104; 369-381.
Settipane GA, Pudupakkam RK. Aspirin intolerance. III. Subtypes familial occurrence and cross-reactivity with tartrazine. J Allergy Clin Immunol 1975; 56(3): 215-221.
Doeglas HMG. Reactions to aspirin and food additives in patients with chronic urticaria, including the physical urticarias. Br J Dermatol 1975; 93: 135-144.
Doeglas HMG. Dietary treatment of patients with chronic urticaria and intolerance of aspirin and food additives. Proceedings Verhandlungsberichte Congress 1977: 308-310.
Ros AM, Juhlin L, Michaëlsson G. A follow-up study of patients with recurrent urticaria and hypersensitivity to aspirin, benzoates and azo dyes. Br J Dermatol 1976; 95: 19-24.
Settipane GA, Chafee FH, Postman IM, et al. Significance of tartrazin sensitivity in chronic urticaria of unknow etiology. J Allergy Clin Immunol 1976; 57(6): 541-546.
Gibson A, Clancy R. Management of chronic idiopathic urticaria by the identification and exclusion of dietary factors. Clin Allergy 1980; 10: 699-704.
Stenius BSM, Lemola M. Hypersensitivity to acetylsalicylic acid (ASA) and tartrazin in patients with asthma. Clin Allergy 1976; 6: 119-129.
Weber RW, Hoffman M, Raine DA, Nelson HS. Incidence of bronchoconstriction due to aspirin, azo dyes, non-azo dyes and preservatives in a population of perennial asthmatics. J Allergy Clin Immunol 1979; 64(1): 32-37.
Ortolani C, Pastorello E, Luraghi MT, Della TF, Bellani M, Zanussi C. Diagnosis of intolerance to food additives. Ann Allergy 1984; 53: 587-591.
Hannuksela M, Haahtela T. Hypersensitivity reactions to food additives. Allergy 1987; 42: 561-575.
Chafee FH, Settipane GA. Asthma caused by FD & C approved dyes. J Allergy 1967; 40 (2): 65-72.
Warin RP, Smith RJ. Challenge test battery in chronic urticaria. Br J Dermatol 1976; 94: 401-406.
Farr RS, Spector SL, Wangaard CH. Evaluation of aspirin and tartrazine idiosyncrasy. J Allergy Clin Immunol 1979;64 (6): 667-668.
Wüthrich B. Adverse reactions to food additives. Ann Allergy 1993; 71: 379-384.
Moneret-Vautrin DA, Demange G, Selve C, Grilliat JP, Savinet H. Induction d’une hypersensibilité réaginique à la tartrazine chez le lapin: Immunisation par voie digestive par le conjugué covalent tartrazine-séralbumine humaine. Ann Immunol (Inst. Pasteur) 1979; 130C: 419-430.
Johnson HM, Peeler JT Smith BG. Tartrazine: Quantitative passive hemagglutination studies on a food-borne allergen of small molecular weight. Immunochemistry 1971; 8: 281-287.
Murdoch RD, Pollock I, Naeem S. Tartrazine induced histamine release in vivo in normal subjects. J Roy Coll Phys London 1987; 21(4): 257-261.
Abbas AK, Lichtman AH, Pober JS. Cellular and molecular Immunology, Philadelphia, W.B. Saunders Company : 292-297.
Neuman I, Elian R, Nahum H, Shaked P, Creter D. The danger of ‘yellow dyes’ (tartrazine) to allergic subjects. Clin Allergy 1978; 8: 65-68.
Valverde E, Vich JM, Garcia-Calderón JV, Garcia-Calderón PA. In vitro stimulation of lymphocyte in patients with chronic urticaria induced by additives and food. Clin Allergy 1980; 10: 691-698.
Borgeat P. Leukotrienes: A major step in the understanding of immediate hypersensitivity reactions. J Med Chem ; 24 (2): 121-126.
Lahti A, Oikarinen A, Viinikka L, Ylikorkala O, Hannuksela M. Prostoglandins in contact urticaria induced by benzoic acid. Acta Derm. Venerol(Stockh) 1983; 63: 425-427.
Warrington RJ, Sauder PJ, Mcphillips S. Cell-mediated immune responses to artifical food additives in chronic urticaria. Clin Allergy 1986; 16: 527-533.
Trautlein JJ, Mann JW. Anaphylactic shock caused by yellow dye (FD and C no: 5, FD and C No: 6) in an enema. Ann Allergy 1978; 41: 28-29.
Kreindler J, Slutsky J, Haddad ZH. The effect of food colors and sodium benzoate on rat periotoneal mast cells. Ann Allergy 1980; 44(2): 76-81.
Supramaniam G, Warner JO. Artifical food additive intolerance in patients with angio-oedema and urticaria. Lancet 1986; 18: 907-909.
Röhlich P, Anderson P, Unvas B. Electron microscope observations on compound 48/80-induced degranulation in rat mast cells. J Cell Biol 1971; 51: 465-483.
Anderson P, Slorach SA Uvnas B. Sequential exocytosis of storage granules during antigen-induced histamine release from sensitized rat mast cells in vitro an electron microscopic study. Acta Physiol Scand 1973; 88: 369-372.
Moriyasu S, Yamura T. Electron microscopic studies of mast cell degranulation. Acta Derm Venerol Suppl (Stockh) 1973; 73: 149-156.
Drake-Lee AB, Price JM, Milford CM, Bickerton RC. Nasal mast cells: a preliminary report on their ultrastructure. J Laryngol Otol 1987; 13: 1-17.
Michaëlsson G, Juhlin L. Urticaria induced by preservatives and dye additives in food and drugs. Br J Dermatol ; 88: 525-532.
Lagunoff D. Contributions of electron microscopy to the study of mast cells. J Invest Dermatol 1972; 58(5): 311.