Sub-Kronik stresin neden olduğu depresyon ve anksiyete bozukluklarında tDAS’ın etkileri

Amaç: Stres duygu, düşünce ve davranışları etkileyerek kişide depresyon, anksiyete gibi nöropsikiyatrik hastalıklara sebep olmaktadır. Bu çalışmada sub-kronik stres sonrası oluşan depresyon ve anksiyete bozukluklarına tDAS’ın terapötik etkilerinin incelenmesi amaçlanmıştır. Yöntem: 290-310 g ağırlığındaki 40 adet erkek Wistar sıçanlar kontrol, tDAS, stres ve stres+tDAS olmak üzere 4 gruba ayrılmıştır. Stres modeli olarak 7 gün boyunca günde 2 saat hareketsizlik stresi uygulanmıştır. tDAS ve stres+tDAS grubundaki sıçanlara stres maruziyetinin 5. gününden itibaren 3 gün boyunca 1 mA anodal tDAS uyarımı yapılmıştır. Deneyin 7. gününde sıçanların anksiyete ve depresyon davranışları açık alan testi ve yükseltilmiş artı labirent testi ile değerlendirilmiştir. Bulgular: Kontrol ve tDAS grupları arasında lokomotor aktivite, yükseltilmiş artı labirent testi verilerinde anlamlı değişim bulunmamıştır. Kontrol grubuna göre stres grubu sıçanların lokomotor aktivite düzeylerinde anlamlı azalma görülürken (p

The effects of tDCS on depression and anxiety disorders induced by Sub-Chronic stress

Objective: Stress causes neuropsychiatric diseases such as depression and anxiety in the person by affecting emotions, opinions and behaviors. In this study, the aim was to investigate the therapeutic effects of tDCS on depression and anxiety disorders that occur after subchronic stress. Methods: 40 male Wistar rats weighing 290-310 g were divided into four groups as control, tDCS, stress and stress+tDCS. Restraint stress was applied for 7 days (2 h/day) as a stress model. Rats in the tDCS and stress+tDCS groups were performed the stimulation of 1 mA anodal tDCS for three consecutive days from the 5th day of stress exposure. On the 7th day of the experiment, the anxiety and depression behaviors of the rats were evaluated with the open field test and the elevated plus maze test. Results: No significant changes were found in the locomotor activity, elevated plus maze test data between control and tDCS groups. In the stress group rats compared to the control group, there was a significant decrease in the locomotor activity levels (p

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