Roberto Cañete VILLAFRANCA, Daniella Rodrigues GONÇALVES, Fabiana VALADARES, Maria Rita Carvalho Garbi NOVAES, Marília da Cunha MENEZES, Mariana Campos REIS

Effect of dietary supplementation with Agaricus sylvaticus fungus on the hematology and immunology systems of breast cancer patients undergoing chemotherapy

Amaç: Kanser hastaları hastalığın seyri sırasında immünolojik ve hematolojik değişimler gelişmesine eğilimlidir. Tıbbi mantarlar, prognozda iyileşme ve fizyolojik yanıtı artırıcı etkiyle bağışıklık ve hematopoetik sistemleri uyarabilirler. Bu çalışmada Agaricus sylvaticus ile besin takviyesi sonrası kemoterapi gören meme kanserli hastalardaki hematolojik ve immünolojik parametrelerin değerlendirilmesi amaçlanmıştır. Yöntem: Randomize seçilmiş, çift-kör, plasebo kontrollü bir çalışma uygulanmıştır. 46 hastaya (grup II ve III) rastgele olarak ya plasebo ya da besin kaynağı olarak A. sylvaticus (2,1 g/gün) verilmiştir. Hastalara 3 doz (n=26) ve 6 doz kemoterapi uygulanmış, klinik ve laboratuvar değerlendirmeleri yapılmıştır. Çalışma sonuçları Microsoft Excel 2003 ve R-version 2.11.1 kullanılarak analiz edilmiş ve p

Agaricus sylvaticus mantarının kemoterapi gören meme kanseri hastalarında besin takviyesi olarak hematolojik ve bağışıklık sistemine etkisi

Objective: Patients with cancer tend to develop hematological and immunological alterations during the disease process. Medicinal fungi can stimulate the immune and hematopoietic systems, promoting improvements in the prognosis and physiological response. In this trial it is aimed to evaluate changes in hematological and immunological parameters in patients with breast cancer undergoing chemotherapy after dietary supplementation with Agaricus sylvaticus. Method: A randomized, double-blind, placebo-controlled study was carried out. 46 patients (stadiums II and III), were randomly assigned to receive either: nutritional supplement with A. sylvaticus (2.1 g/day) or placebo. Patients received three cycles (n=26) and six cycles (n=20) of chemotherapy. Clinical and laboratory evaluations were performed. The results were analyzed using Microsoft Excel 2003 and R-version 2.11.1, significant results at p≤ 0.05. Results: The A. sylvaticus group showed an increase of hematocrits (p=0.04), red blood count (p=0.03), mean corpuscular hemoglobin concentration (p=0.001), leukocytes (p=0.03), monocytes (p=0.001), and total lymphocyte count (p=0.009) after three months. Those changes were not observed in the placebo group. After six months, patients receiving A. sylvaticus showed increased levels of red blood count (p=0.02), hemoglobin (p=0.02), hematocrits (p=0.02), corpuscular hemoglobin concentration (p=0.02), leukocytes (p=0.02); lymphocytes (p=0.02), neutrophils (p=0.02) and TLC (p=0.02). The placebo group showed a reduction in leukocytes (p=0.004), basophiles (p=0.005) and TLC (p=0.01). Conclusion: The results suggest the usefulness of dietary supplementation with A. sylvaticus in patients with breast cancer undergoing chemotherapy.

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