Vahid RAISSI, Gita ALİZADEH, Fatemeh BAYAT, Elham AKHLAGHİ, Muhammad GETSO, Omid RAIESI, Ali ABDOLLAH, Asma İBRAHİM, Sakineh AKBARİ, Zahra NAVİ, Soudabeh ETEMADI

Association between T3, T4, and TSH hormones proportion and Toxoplasma gondii anti-IgG seroprevalence in patients suffering from clinical and drug-controlled thyroid dysfunctions in southeastern Iran

Objective: Toxoplasma gondii is an important agent responsible for many hormonal and behavioral disorders in humans. The main objective of this study was to evaluate the hypothesis that ‘T. gondii infection interferes with thyroid hormones secretion or thyroid drug treatment’. Methods: This is a cross-sectional study that involved 249 patients suffering from thyroid dysfunctions, divided into 3 groups: hypothyroidism (n=107), hyperthyroidism (n=96), and drug-controlled thyroid disorders (n=91), referred to Seyedoshohada Kerman private clinic. Serum samples were tested for thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4) along with Toxoplasma anti-IgG using ELISA technique. Demographic information was collected using a demographic sheet Results: The seroprevalence of Toxoplasma gondii IgG antibodies among patients with hypothyroidism, hyperthyroidism, and drug-controlled thyroid disorders was 22.4%, 19.8%, and 22% respectively. The mean value of thyroid hormones of positive T. gondii samples in hypothyroidism, hyperthyroidism, and drug-controlled thyroid disorders was TSH=7.95, T3=1.12, T4=2.36; TSH=0.14, T3=1.42, T4=7.85; and TSH=2.75, T3=1.12, T4=1.45 respectively. The seropositivity of Toxoplasma gondii infection was 40.4% among individuals with a history of contact with pets and 26.3% among the rural dwellers. Conclusion: There was no significant difference between T. gondii infection among the three study groups. A comparison of serum levels of thyroid hormones between infected and non-infected individuals in the above-mentioned groups illustrated that latent toxoplasmosis wasn’t significantly associated with thyroid hormones secretion. Also, contact with pets and the rural lifestyle has a positive association with T. gondii seroprevalence

Güneydoğu İran’da klinik ve ilaç kontrollü tiroid fonksiyon bozukluğu olan hastalarda T3, T4 ve TSH hormonları oranı ile Toxoplasma gondii anti-IgG seroprevalansı arasındaki ilişki

Amaç: Toxoplasma gondii, insanlarda birçok hormonal ve davranışsal bozukluktan sorumlu olan önemli bir ajandır. Bu çalışmanın temel amacı, ‘T. gondii enfeksiyonunun tiroid hormonlarının salgılanmasına veya tiroid ilaç tedavisine müdahale ettiği hipotezini değerlendirmektir. Yöntem: Bu, Seyedoshohada’daki Kerman özel kliniği’ne yönlendirilen, tiroid disfonksiyonlarından muzdarip 249 hastayı 3 gruba ayıran kesitsel bir çalışmadır: hipotiroidizm (n=107), hipertiroidizm (n=96) ve ilaç kontrollü tiroid bozuklukları (n=91). Serum örnekleri tiroid stimulan hormon (TSH), triiyodotironin (T3) ve tiroksin (T4) ile Toksoplazma anti-IgG için ELISA tekniği kullanılarak test edildi. Demografik bilgiler bir demografik anket kullanılarak toplandı. Bulgular: Hipotiroidizm, hipertiroidizm ve ilaç kontrollü tiroid bozukluğu olan hastalarda Toxoplasma gondii IgG antikorlarının seroprevalansı sırasıyla %22.4, %19.8 ve %22 idi. Hipotiroidizm, hipertiroidizm ve ilaç kontrollü tiroid bozukluklarında pozitif T. gondii örneklerinin tiroid hormonlarının ortalama değeri TSH ;7.95, T3;1.12, T4;2.36; TSH;0.14, T3;1.42, T4;7.85; ve sırasıyla TSH;2.75, T3;1.12, T4;1.45 idi. Toxoplasma gondii enfeksiyonunun seropozitifliği, evcil hayvanlarla temas öyküsü olan bireylerde %40.4 ve kırsalda yaşayanlarda %26.3 idi. Sonuç: Üç çalışma grubu arasında T. gondii enfeksiyonu arasında anlamlı bir fark yoktu. Yukarıda belirtilen gruplarda enfekte olan ve olmayan bireyler arasında serum tiroid hormon seviyelerinin karşılaştırılması, latent toksoplazmozun tiroid hormonlarının salgılanmasıyla önemli ölçüde ilişkili olmadığını gösterdi. Ayrıca, evcil hayvanlarla temas ve kırsal yaşam tarzı, T. gondii seroprevalansı ile pozitif bir ilişkiye sahipti.

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