Onur BAYKARA, Nur BUYRU, Ezel ERŞEN, Şebnem BATUR

Vitamin D bağlayan protein gen polimorfizmlerinin akciğer kanserindeki rolü

Amaç: Bu çalışmada GC geninin farklı alellerinin akciğer kanseri etiyolojisindeki rolü araştırıldı.Çalışma planı: Çalışmaya akciğer kanserli 77 hasta (73 erkek, 4 kadın; ort. yaş 59.6±9.2 yıl; dağılım 21-72 yıl) ve 25 sağlıklı birey (21 erkek, 4 kadın; ort. yaş 47.3±5.4 yıl; dağılım 23-61 yıl) dahil edildi. Tüm katılımcıların vitamin D bağlayan protein genindeki polimorfizmler polimeraz zincir reaksiyonu- restriksiyon parça uzunluk polimorfizmi yöntemi ile incelendi.Bulgular: Hastaların %32.4’ünde 1S-2, %28.6’sında 1F-1S, %28.6’sında 1S-1S, %7.8’inde 1F-2 ve %2.6’sında 1F-1F genotipi bulunurken kontrol grubunda genotip frekansı sırasıyla %28, %24, %36, %4 ve %8 idi (p=0.35).Sonuç: Vitamin D bağlayan protein gen polimorfizmleri ve akciğer kanseri arasında herhangi bir ilişki saptanmadı.

Role of vitamin D binding protein (VDBP) gene polymorphisms in lung cancer

Background: This study aims to investigate the role of different alleles of GC gene in the etiology of lung cancer. Methods: The study included 77 patients with lung cancer (73 males, 4 females; mean age 59.6±9.2 years; range 21 to 72 years) and 25 healthy individuals (21 males, 4 females; mean age 47.3±5.4 years; range 23 to 61 years). Polymorphisms in vitamin D binding protein gene of all participants were examined by polymerase chain reaction-restriction fragment length polymorphism method. Results: Of the patients, the genotype 1S-2 was found in 32.4%, 1F-1S in 28.6%, 1S-1S in 28.6%, 1F-2 in 7.8% and 1F-1F in 2.6%, while the genotype frequencies in control group were 28%, 24%, 36%, 4% and 8%, respectively (p=0.35). Conclusion: We did not detect any relationship between vitamin D binding protein gene polymorphisms and lung cancer.

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