Klinik T1aN0M0 akciğer adenokarsinomunda lenf nodu metastazının öngördürücülerinin analizi

Amaç: Bu çalışmada T1aN0M0 akciğer adenokarsinomlu hastalarda lenf nodu metastazının öngördürücüleri belirlendi. Çalışma planı: Bu retrospektif çalışmaya Ocak 2011 - Ekim 2015 tarihleri arasında tedavi edilen T1aN0M0 klinik evre akciğer adenokarsinomlu toplam 364 hasta (170 erkek, 194 kadın; ort. yaş 60.8±8.4 yıl; dağılım 33-82 yıl) alındı. Tıbbi kayıtlar incelendi ve ilgili klinik veriler ve patoloji sonuçları kaydedildi. Lenf nodu metastazının öngördürücülerini belirlemek için tek değişkenli ve çok değişkenli analizler yapıldı. Bulgular: Çok değişkenli analizde buzlu cam opasitesi, yüksek serum karsinoembriyonik antijen konsantrasyonları (>5 ng/mL) ve patojenik tip T1a akciğer adenokarsinomunda lenf nodu metastazının öngördürücüleri olarak bulundu. Solid nodüllerde ise; tümör çapı, hava bronkogramı ve yüksek serum karsinoembriyonik antijen konsantrasyonları lenf nodu metastazının öngördürücüleri idi. Sonuç: Lenf nodu metastazı, yalnızca buzlu cam opasitesi veya

Analysis of predictors of lymph node metastasis in clinical T1aN0M0 pulmonary adenocarcinoma

Background: This study aims to identify the predictors of lymph node metastasis in patients with T1aN0M0 adenocarcinoma of the lung.Methods: In this retrospective study, a total of 364 patients(170 males, 194 females; mean age 60.8±8.4 years; range: 33 to 82 years) with clinical stage T1aN0M0 pulmonary adenocarcinoma who were treated between January 2011 and October 2015 were included. Medical records were analyzed and relevant clinical data and pathological results were recorded. Univariate and multivariate analyses were performed to identify the predictors of lymph node metastasis.Results: Multivariate analysis demonstrated that ground-glass opacity, high serum carcinoembryonic antigen concentrations (>5 ng/mL), and pathogenic type were the predictors of lymph node metastasis in T1a pulmonary adenocarcinoma. For solid nodules, tumor diameter, air bronchogram, and high serum carcinoembryonic antigen concentrations were the predictors of lymph node metastasis.Conclusion: Lymph node metastasis cannot be found in patients with clinical stage T1aN0M0 pulmonary adenocarcinoma presenting as a pure ground-glass opacity or mixed tumor with solid component of diameter

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