Erdal ŞİMŞEK, Bahadır DAĞLAR, Kemalettin ERDEM, Onursal BUĞRA, Mehmet Alper ÇALIŞAL

Kardiyopulmoner baypasta tek ve çift rezervuarlı oksijenatör kullanılmasının enflamatuvar yanıt üzerine etkileri

Amaç: Bu çalışmada, kardiyopulmoner baypas (KPB) ile yapılan açık kalp cerrahisinde tek ve çift rezervuarlı oksijenatörün sitokin, kompleman, C-reaktif protein (CRP) ve beyaz kan hücreleri (WBC) üzerindeki etkileri araştırıldı. Çalışma planı: Hastalar tek (kontrol grubu) ve çift rezervuarlı oksijenatör kullanımına (çalışma grubu) göre iki eşit gruba ayrıldı. Her iki grupta KPB öncesi, heparin verildikten sonra ve KPB sonrası altıncı saat ve 24. saatlerde kan örnekleri alındı. Gruplar arasında kompleman (C3, C4), tümör nekroz faktör-alfa (TNF-alfa), interlökinler (IL 6-8-10), CRP ve WBC düzeyleri analiz edildi.Bulgular: Tek ve çift rezervuarlı oksijenatör kullanılan her iki hasta grubu yaş, cinsiyet, boy, vücut ağırlığı ve eşlik eden hastalıklar açısından benzerdi. Her iki hasta grubu arasında C3, C4, TNF-alfa, IL-6, IL-8, IL-10, CRP ve WBC düzeyleri arasında, KPB öncesi ve KPB sonrası altıncı saat ve 24. saatte istatistiksel olarak anlamlı bir fark bulunmadı.Sonuç: Açık kalp ameliyatlarında KPB esnasında tek ve çift rezervuarlı oksijenatör kullanılması, enflamatuvar yanıt üzerinde anlamlı bir etkiye sahip değildir.

The effects of single and dual reservoired oxygenators on inflammatory response in cardiopulmonary bypass

Background: This study aims to investigate the effects of single and dual reservoired oxygenators used in open heart surgery using cardiopulmonary bypass (CPB) on the cytokine, complement, C-reactive protein (CRP) and white blood cells (WBC). Methods: Patients were divided into two equal groups according to single (control group) and dual reservoired oxygenators (study group). Blood samples were collected before CPB, after heparin administration and at six and 24 hours following CPB in both groups. We analyzed the levels of complement (C3, C4), tumor necrosis factor-alpha (TNF-alpha), interleukins (IL 6-8-10), CRP, and WBC.Results: Both groups using single and double reservoired oxygenators were similar in terms of age, sex, height, body weight, and comorbidities. There was no difference in C3, C4, TNF-alpha, IL-6, IL-8, IL-10, CRP and WBC levels, before CPB and at six and 24 hours following CPB in both groups.Conclusion: Using single and double reservoired oxygenators during CPB in open heart surgery has no significant effect on inflammatory response.

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