Adnan YALÇINKAYA, Mustafa PAÇ, İrfan TAŞOĞLU, Gökhan LAFÇI, Ahmet SARITAŞ, Mahmut M. ULAŞ, Ömer F. ÇİÇEK, Ahmet T. ULUS

Could mean platelet volume be a predictive marker for mechanical valve thrombosis?

Amaç: Bu çalışmada ortalama trombosit hacminin mekanik kapak trombozundaki klinik önemi ve akut mekanik kapak trombozuna işaret eden bir belirteç olma olasılığı araştırıldı. Çalışma planı: Ortalama trombosit hacmi mekanik kapak trombozu olan ardışık 28 hastada (ort. yaş 47.3±12.8 yıl) ve 91 kontrol olgusunda (ort. yaş 46.1±5.8 yıl) ölçüldü. Çalışma grubunda kan örnekleri ilk başvuruda (grup 1, ilk ölçüm) ve taburcu olduktan sonraki ameliyat sonrası rutin kontrolde (grup 1, ikinci ölçüm) toplandı. İlk kontrol grubu (grup 2) mekanik kapağı olan, mekanik kapak trombozu öyküsü olmayanlar olarak tanımlandı. İkinci kontrol grubu (grup 3) kateterizasyon yapılan ve normal koroner anjiyogramları olan kardiyak hastalar arasından ardışık bir şekilde seçildi. Mekanik kapak obstrüksiyonu tanısı klinik inceleme, ekokardiyografi ve sinefloroskopi temel alınarak konuldu. Bulgular: Ortalama trombosit hacmi grup 1’deki (ilk ölçüm) hastalarda diğer grup 1 (ikinci ölçüm), grup 2 ve grup 3’deki hastalardan anlamlı olarak yüksek idi (p0.05). Sonuç: Mekanik kapak trombozu olan hastalarda ortalama trombosit hacminin kontrol grubuna göre daha yüksek olduğu ilk defa gösterildi. Bu nedenle ortalama trombosit hacmi, mekanik kapak trombozu olan hastalarda trombozun takip belirteci olarak kullanılabilir.

Ortalama trombosit hacmi mekanik kapak trombozuna işaret eden bir belirteç olabilir mi?

Background: In this study, we investigated the clinical importance and possibility of mean platelet volume to be a predictive marker for acute mechanical valve thrombosis. Methods: Mean platelet volume was measured in 28 consecutive patients (mean age 47.3±12.8 years) with mechanical valve thrombosis and 91 control subjects (mean age 46.1±5.8 years). In the study group, blood samples were collected at the first admission (group 1, first measurement) and in the postoperative routine control after discharge (group 1, second measurement). The first control group (group 2) was defined by having a mechanical valve with no history of thrombosis of the mechanical valve. The second control group (group 3) was selected in a consecutive manner from the catheterized cardiac patients who proved to have normal coronary angiograms. Diagnosis of mechanical valve obstruction was based on clinical examination, echocardiography, and cinefluoroscopy. Results: Mean platelet volume was significantly higher in group 1 (first measurement) patients than in group 1 (second measurement), group 2 and group 3 patients (p0.05). Conclusion: It was shown for the first time that patients with mechanical valve thrombosis have higher mean platelet volumes than control subjects. Therefore, mean platelet volume might be used as a follow-up marker of thrombosis in patients with mechanical valve thrombosis.

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