Ayliz VELİOĞLU, Batuhan ÖZAY, Murat SARGIN, Erol KURÇ, Şahin ŞENAY, Müge TAŞDEMİR, Serap Aykut AKA, Okan YÜCEL, Gökcen ORHAN

Alterations in bronchial nitric oxide release and pulmonary function after cardiopulmonary bypass in patients with normal and decreased respiratory capacity

Amaç: Bu çalışmanın amacı normal ve azalmış respiratuvar kapasiteli, aorta koroner bypass cerrahisi ve kardiyopulmoner bypass geçiren hastalarda pulmoner fonksiyonları ve vasküler endotelyal nitrik oksit (NO) salınımı ile birlikte bronşiyal NO salınımındaki değişimleri değerlendirmektir. Çalışma planı: Yirmi normal pulmoner fonksiyonlara sahip hasta ile 20 azalmış pulmoner fonksiyonlu hasta çalışmaya dahil edildi. Entübasyondan hemen sonra, kardiyopulmoner bypass sonrası ve ameliyat sonrası altıncı saatte endotrakeal aspirasyon ve plazma örnekleri alındı. Respiratuvar fonksiyon durumları, bronşiyal ve vasküler NO salınımları değerlendirildi. Bulgul ar: Her iki grupta da, plazma ve bronşiyal NO salınımı ve respiratuvar kapasite kardiyopulmoner bypass sonrası yavaşça azaldı; respiratuvar indeks değerleri önemli derecede kötüleşti. Sonuç: Bu bulgular, kardiyopulmoner bypass’a girecek olan kronik obstrüktif akciğer hastalığı bulunanların, normal respiratuvar kapasiteli hastalarla benzer akciğer hasarına maruz kaldıklarını göstermiştir.

Normal ve azalmış respiratuvar kapasiteli kardiyopulmoner bypass hastalarında pulmoner fonksiyon ve bronşiyal nitrik oksit salımındaki değişimler

Background: The aim of this study is to evaluate the pulmonary function and define the alterations in bronchial nitric oxide (NO) release in correlation with the vascular endothelial NO release in patients with normal and decreased respiratory capacity undergoing coronary artery bypass graft surgery under cardiopulmonary bypass. Methods: Twenty patients with normal pulmonary functions and 20 patients with decreased respiratory function were involved in the study. Endotracheal aspiration samples and plasma samples were obtained just after the entubation, at the end of the cardiopulmonary bypass and at the postoperative sixth hour. The respiratory functional status, bronchial NO release and vascular NO release were evaluated. Results: The NO levels in plasma and bronchial samples, and respiratory capacity were gradually decreased; and respiratory index values significantly deteriorated in both groups. Conclusion: These findings show that patients with chronic obstructive lung disease undergoing cardiopulmonary bypass have similar lung damage with patients who have normal respiratory capacity.

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