Fatma ÜÇSULAR, Ceyda ANAR, Özgür BATUM, Gülistan KARADENİZ, Gülru POLAT, Melih BÜYÜKŞİRİN, Mine GAYAF, Filiz GÜLDAVAL, Aysu AYRANCI, Aylin ALPÖZEN, Zeynep SEYMENOĞLU

Pandeminin erken evresinde İzmir’de bir 3. basamak eğitim araştırma hastanesinde koronavirüs hastalığı belirtileri olan sağlık çalışanlarının klinik durumu

Giriş: Pandeminin erken evresinde İzmir’de bir 3. basamak eğitim araştırma hastanesinde COVID-19’lu Sağlık çalışanlarının klinik özelliklerini ve sonuçları hakkındaki verileri araştırmak ve raporlamaktır. Materyal ve Metod: Bu, doğrulanmış COVID-19 hastalarından bir 3. basamak eğitim araştırma hastanesinden toplanan kesitsel veriler kullanılarak yapılan tek merkezli, retrospektif, tanımlayıcı, gözlemsel bir çalışmadır. Hastaların demografik ve klinik özellikleri, mortalite oranları ve hastaneye yatışla ilişkili faktörleri analiz edildi. Bulgular: Hastanemizde 15 Mayıs 2020 itibariyle 49’u (%10.2) sağlık çalışanı olan 480 hastaya COVID-19 teşhisi kondu. Ortalama yaş 40.0 ± 8.45 (%75.5 kadın) idi. En sık görülen semptomlar öksürük (%32.7), ateş %30.6), miyalji (%14.3) idi. Hastaların%32.7’sinde ek hastalık mevcuttu. Bu sağlık çalışanlarının çoğunu hemşireler (%53.1) ve doktorlar (%18.4) oluştururken geri kalanın 14’ü (%28.6) temizlik personeli ve idari personeldi. Nötrofil, lenfosit ve trombosit değerleri hastanede yatan hastalarda istatistiksel olarak daha düşüktü. Akciğer grafisinde infiltrasyon varlığı ile hastanın semptomu ve hastalığın şiddeti arasında istatistiksel olarak anlamlı bir ilişki vardı (sırasıyla p= 0.002 ve 0.009). Sonuç: Sağlık çalışanlarında COVİD-19 sıklığı yüksektir. Türkiye’de tek bir merkezden koronavirüs bulaşmış sağlık çalışanlarının özelliklerini sunuyoruz

Clinical presentation of health care workers with symptoms of coronavirus disease 2019 at the İzmir tertiary education hospital, during an early phase of the pandemic

Clinical presentation of health care workers with symptoms of coronavirus disease 2019 at the İzmir tertiary education hospital, during an early phase of the pandemic Introduction: The aim of this study is to investigate and report on the data regarding the clinical characteristics and outcomes of healthcare workers with COVID-19 at tertiary education hospitals from Turkey. Materials and Methods: This was a single center, retrospective, descriptive and observational study using cross-sectional data, which were collected from confirmed COVID-19 patients at a tertiary education hospital. Patients’ demographic and clinical characteristics, mortality rates, and the factors associated with hospitalization were analyzed. Results: By May 15, 2020, 480 patients were diagnosed with COVID-19 in our hospital where 49 (10.2%) of whom were HCWs. The mean age was 40.0 ± 8.45 (75.5% female). The most common symptoms were cough (32.7%), fever (30.6%), and myalgia (14.3%). Comorbidities were present in 32.7% of the patients. Most of the HCWs were nurses (53.1%) and physicians (18.4%), and the remaining 14 (28.6%) were cleaning and administrative staff. The severity of the disease was mild in 65.3% and severe in 34.7% HCWs. Leukocyte, neutrophil, lymphocyte and platelet values were statistically lower in hospitalized patients. There was a statistically significant relationship between the presence of infiltration on the chest X-ray, and the patient’s symptoms with the severity of the disease (respectively p= 0.002 and 0.009). Conclusion: In conclusion, the frequency of COVID-19 in healthcare workers is high. The study presents the characteristics of HCWs infected with coronavirus from a single center in Turkey.

PDF

___

1. Li Q, Guan X, Wu P, Whang X, Zhou L, Tong Y et al. Early transmission dynamics in Wuhan, China, of novel coronavirus- infected pneumonia. N Engl J Med 2020; 382(13): 1199-207.
2. Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable batorigin. Nature 2020; 579(7798): 270-3.
3. Phan LT, Nguyen TV, Luong QC, Nguyen TV, Nguyen HT, Le HQ, et al. Importation and human-to-human transmission of a novel coronavirus in Vietnam. N Engl J Med 2020; 382(9): 872-4.
4. Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk factors associated with acute respiratory distress syndrome and death in patientswith coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med 2020.
5. Chen J. Pathogenicity and transmissibility of 2019-nCoV-A quick overview and comparison with other emerging viruses. Microbes Infect 2020; 22(2): 69-71.
6. Mahase E. Coronavirus COVID-19 has killed more people than SARS and MERS combined, despite lower casefatality rate. BMJ 2020; 368: m641.
7. Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med 2020; 382(12): 1177-9.
8. Wang D, Hu B, Hu C, Zhu F, Liu X, Zang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020; 323(11): 1061-9.
9. Cho SY, Kang JM, Ha YE, Park GF, Lee JY, Ko JH, et al. MERS-CoV outbreak following a single patient exposure in an emergency roomin South Korea: an epidemiological outbreak study. Lancet 2016; 388(10048): 994-1001.
10. T. C. Ministry Of Health General Directorate Of Public Health, Covid-19 (Sars-Cov2 Infection) Directory, Coronavirus Scientific Advisory Board, Turkey. 2020.
11. Jiaojiao C, Yang N, Wei Y, Yue H, Zhang F, Zhao J, et al. Clinical characteristics of 54 medical staff with COVID-19: A retrospective study in a single center in Wuhan, China J Med Virol 2020: 10.1002/jmv.25793
12. Chan JFW, Yuan S, Kok KH, Chu H, Yang J, Xing F, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person‐to‐person transmission: a study of a family cluster. Lancet 2020; 395(10223): 514-23.
13. Macintyre CR, Seale1 H, Yang P, Zhang Y, Shi W, Almatroudi A, et al. Pang.Quantifying the risk of respiratory infection in healthcare workers performing high-risk procedures. Epidemiol Infect 2014; 142: 1802-8.
14. Ran l, Chen X, Wang Y, Wu W, Zhang L, Tan X. Risk Factors of Healthcare Workers with Corona Virus Disease 2019: A Retrospective Cohort Study in a Designated Hospital of Wuhan in China, 2020.
15. Wen J, Hao T, Hu X. Doctor’s Workload in China: A Statusquo Study. Chin J Evid-based Med 2015; 15(2): 133-6.
16. Li D, Wu S. Analysis on the health status and influencing factors of medical workers in a city of Fujian province. The Medical Forum 2016; 20(14): 1893-5.
17. Weaver MD, Landrigan CP, Sullivan JP, O’Brien CS, Qadri S, Viyaran N, et al. The association between resident physician work hour regulations and physician safety and health. Am J Med 2020; 133(7): e343-e354
18. Liu, Y. Yan LM, Wan L, Xiang TX, Le A, Liu JM, et al., Viral dynamics in mild and severe cases of COVID-19. Lancet Infect Dis 2020; 20(6): 656-7.
19. Wenjing Y, Xiopan L, Xing L, Chen J, Min H, Zhang D, et al. Dynamic changes of D-dimer and neutrophil-lymphocyte count ratio as prognostic biomarkers in COVID-19. Respir Res 2020; 21: 169.