Buğra KERGET, Elif YILMAZEL UÇAR, Metin AKGÜN, Ömer ARAZ, Ahmet KIZILTUNÇ, Abdullah Osman KOÇAK, Ferhan KERGET

COVID-19 hastalarında serum vitamin D düzeyinin klinik seyir ve prognozla ilişkisinin değerlendirilmesi

Giriş: Aralık 2019 tarihinde Çin’in Wuhan kentinde ortaya çıkan SARS-CoV-2 (COVID-19) kısa süre içinde altı milyonu aşkın insanı enfekte etti. COVID-19‘da birçok laboratuvar parametresinin morbidite ve mortaliteyle ilişkisi tanımlanmıştır. Çalışmamızda serum vitamin D düzeyinin klinik seyir ve prognozla ilişkisini tespit etmeyi amaçladık. Materyal ve Metod: 24 Mart 2020-15 Mayıs 2020 tarihleri arasında Atatürk Üniversitesi Göğüs Hastalıkları Kliniğinde yatmış nazofarengeal sürüntüsünden real-time PCR yöntemiyle COVID-19 tespit edilmiş 88 hasta ve hastanemizde rutin kontrol sonrasında realtime PCR’si negatif çıkan asemptomatik 20 gönüllü sağlık personeli kontrol grubu olmak üzere 108 kişi çalışmamıza dahil edildi. Bulgular: COVID-19 nedeniyle yatırılan hastaların sağlıklı kontrol grubu ile vitamin D düzeyleri arasında yapılan istatistiksel analizinde COVID-19 ile infekte hastalarda daha düşük düzeyde olduğu gözlendi (p= 0.004). MAS gelişen 20 hastada gelişmeyen 68 hastaya nazaran daha düşük düzeyde vitamin D düzeyi gözlendi (p= 0.004). COVID-19 nedeniyle takiplerinde eksitus gelişen hastaların (n= 8) hastaneye geliş vitamin D düzeylerinin yaşayanlarla yapılan karşılaştırılmasında ise eksitus gelişen hastalarda istatistiksel olarak anlamlı düzeyde düşük olarak gözlendi (p= 0.009). Sonuç: COVID-19 pandemisi nedeniyle uzun süren karantinalar güneş ışığından yeterli istifade edilememesine ve vitamin D eksikliğinin daha da ağırlaşmasına neden oldu. COVID-19 ağır klinik seyirden sorumlu olabilecek ve replasmanın kolay uygulanabilir olduğu vitamin D’ye çalışmamız ile tekrar dikkat çekmek istedik.

Evaluation of the relationship of serum vitamin D levels in COVID-19 patients with clinical course and prognosis

Evaluation of the relationship of serum vitamin D levels in COVID-19 patients with clinical course and prognosis Introduction: SARS-CoV-2 (COVID-19), which emerged in Wuhan, China in December 2019, infected more than six million people in a short time. In COVID-19, the relationship of many laboratory parameters to morbidity and mortality has been defined. In our study, we aimed to determine the relationship of serum vitamin D level to clinical course and prognosis. Materials and Methods: This study included 108 patients; 88 patients who stayed in Ataturk University and Erzurum City Hospital between March 24, 2020 and May 15, 2020, who were identified as COVID-19 by real-time PCR method from the nasopharyngeal swab and 20 asymptomatic voluntary medical personnel who tested negative for real-time PCR after routine check-up in our hospital. Results: In statistical analysis conducted between healthy control group and vitamin D levels of patients admitted due to COVID-19, it was observed that patients infected with COVID-19 had a lower level (p= 0.004). In 20 patients developing MAS, a lower level of vitamin D was observed (p= 0.004) compared to 68 patients who did not develop. In the comparison of vitamin D levels of the patients (n= 8) who developed exitus in their follow up due to COVID-19, it was observed that vitamin D levels were statistically significantly lower compared to the living (p= 0.009). Conclusion: Due to COVID-19, pandemic, long-running quarantines caused insufficient use of sunlight and worsening of vitamin D deficiency. We wanted to draw attention again with our study to vitamin D which can be responsible for the heavy clinical course of COVID-19 and whose replacement is easy to apply

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