Necdet POYRAZ, Fahriye KILINÇ, Celalettin KORKMAZ, Tamer ALTINOK, Mehmet Emin YAZAR

Akciğerin inflamatuvar miyofibroblastik tümörü: histopatoloji ve görüntüleme bulguları

İnflamatuvar miyofibroblastik tümör etyolojisi bilinmeyen, klinik ve radyolojik olarak malign tümörleri taklit edebilen bir neoplazidir. Tümör inflamatuvar hücreler, miyofibroblastik iğ hücreleri ve plazma hücrelerinin bir karışımından oluşur. Vücudun herhangi bir bölgesinde ortaya çıkabilir. Pulmoner inflamatuvar miyofibroblastik tümör, özellikle çocukluk çağında en sık görülen primer akciğer kitlesi olmasına rağmen ayırıcı tanılar arasında kendisine yeterince yer bulabilmiş değildir. Bu makalede, pulmoner inflamatuvar miyofibroblastik tümörün patoloji ve görüntüleme bulgularını tartışmayı, klinisyen ve radyologların bu hastalığa aşinalıklarını arttırmayı amaçladık.

Inflammatory myofibroblastic tumor of the lung: histopathology and ımaging findings

Inflammatory myofibroblastic tumor is a neoplasia of unknown clinical etiology that clinically and radiologically tends to mimic a malignant neoplasm. The tumor is histologically composed of a mixture of inflammatory cells, myofibroblastic spindle cells and plasma cells. It can occur in any part of the body. Although pulmonary inflammatory myofibroblastic tumor is the most common primary lung mass especially in childhood, this entity is usually not considered in differential diagnosis of lung nodules or masses. In this article, we aimed to disscus the pathology and imaging findings of the pulmonary inflammatory myofibroblastic tumor and increase the familiarity of radiologists and clinicians to this entity.

PDF

___

1. Wo U, Iverson L. Postinflammatory tumors of the lung; report of four cases simulating xanthoma, fibroma, or plasma cell tumor. J Thorac Surg 1954; 28(1): 55-63.
2. Hytiroglou P, Brandwein MS, Strauchen JA, Mirante JP, Urken ML, Biller HF. Inflammatory pseudotumor of the parapharyngeal space: Case report and review of the literature. Head Neck 1992; 14(3): 230–4.
3. Maves CK, Johnson JF, Bove K, Malott RL. Gastric inflammatory pseudotumor in children. Radiology 1989; 173(2): 381-3.
4. Dehner LP. The enigmatic inflammatory pseudotumours: the current state of our understanding, or misunderstanding. J Pathol 2000; 192(3): 277-9.
5. Karaoglu AS, Demir MH, Ayaz A, Uysal H, Soylemez T, Eren T, et al. Inflammatory myofibroblastic tumor of the breast: a case report. Intl J Human and Health Sci 2020; 4(4): 305-8.
6. Libby EK, Ellis LT, Weinstein S, Hammer RD, Murray KS. Metastatic inflammatory myofibroblastic tumor of the bladder. Urology Case Rep 2019; 23: 10-12.
7. Koç N, Cesur S, Ihvan AN, Bas Y, Polat M. Round Ligaman Kaynakli Retroperitoneal Inflamatuar Myofibroblastik Tümör. Şişli Etfal Hastanesi Tıp Bülteni 2016; 50(4): 330.
8. Bulut G, Almalı A, Erten R, Bayram İ, Turan M, Bulut M. Laringeal inflamatuar myofibroblastik tümör: Nadir bir olgu. J Clin Invest 2015; 6(3).
9. Sulu E, Damadoğlu E, Takir HB, Okur HK, Köroğlu E, Yılmaz A. A case of endobronchial inflammatory pseudotumor invading the mediastinum. Tuberk Toraks 2011; 59(1): 77-80.
10. Weiss SW, Goldblum JR. Fibrous tumors of infancy and childhood. In: Weiss SW, Goldblum JR (eds). Enzinger and Weiss’s soft tissue tumors. China: Mosby Elsevier, 2008: 257-302.
11. Borczuk A, Coffin C, Fletcher CDM. Inflammatory myofibroblastic tumour. In: Travis WD, Brambilla E, Purke AP, Marx A, Nicholson AG (eds). WHO classification of tumours of the lung, pleura, thymus and heart. Lyon: IARC 2015: 121-2.
12. Rossi G, Cavazza A. Akciğer tümörleri (çev). In: Mills SE (eds). Sternberg’s diagnostic surgical pathology. İzmir: O’Tıp Kitabevi, 2016: 1175-221.
13. Hussong JW, Brown M, Perkins SL, Dehner LP, Coffin CM. Comparison of DNA ploidy, histologic, and immunohistochemical findings with clinical outcome in inflammatory myofibroblastic tumors. Mod Pathol 1999; 12(3): 279-86.
14. Coffin CM, Hornick JL, Fletcher CD. Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. Am J of Surg Pathol 2007; 31(4); 509-20.
15. Park SB, Cho KS, Kim JK, Lee JH, Jeong AK, Kwon WJ, et al. Inflammatory pseudotumor (myoblastic tumor) of the genitourinary tract. AJR Am J Roentgenol 2008; 191(4): 1255-62.
16. Kim TS, Han J, Kim GY, Lee KS, Kim H, Kim J. Pulmonary inflammatory pseudotumor (inflammatory myofibroblastic tumor): CT features with pathologic correlation. J Comput Assist Tomogr 2005; 29: 633-9.
17. Agrons GA, Rosado-de-Christenson ML, Kirejczyk WM, Conran RM, Stocker JT. Pulmonary inflammatory pseudotumor: radiologic features. Radiology 1998; 206(2): 511- 8.
18. Ikeda T, Nakano J, Kushida Y, Kadota K, Ishikawa R. Multiple pulmonary inflammatory myofibroblastic tumor. Kyobu Geka 2019; 72(5): 367-70.
19. Huellner MW, Schwizer B, Burger I, Fengels I, Schläpfer R, Bussmann C, et al. Inflammatory pseudotumor of the lung with high FDG uptake. Clin Nucl Med 2010; 35(9): 722- 3.
20. Patankar T, Prasad S, Shenoy A, Rathod K. Pulmonary inflammatory pseudotumour in children. Australas Radiol 2000; 44(3): 318-20.
21. Melloni G, Carretta A, Ciriaco P, Arrigoni G, Fieschi S, Rizzo N, et al. Inflammatory pseudotumor of the lung in adults. Ann Thorac Surg 2005; 79: 426-32.
22. Browne CP, Zeman-Pocrnich C, Dar AR, Wyllie B, Joseph M. A rare case of inflammatory myofibroblastic tumor causing left pulmonary artery stenosis and successfully treated with localized radiotherapy in a patient with perinuclear antineutrophil cytoplasmic antibody vasculitis. Cureus 2020; 12(1): e6709.