Lokman UZUN, Ayhan SÖĞÜT, Elif DAĞLI, Remzi ALTIN, Refika ERSU, Şerefden AÇIKGÖZ, Mehmet Birol UĞUR, Athanasios KADITIS

Obstrüktif uyku apne sendromlu çocuklarda leptin seviyeleri

Obstrüktif uyku apne sendromlu çocuklarda leptin seviyeleriGiriş: Bu çalışmanın amacı çocuklarda leptin seviyeleri üzerinde obstrüktif uyku apne sendromu (OUAS)'nun etkisini değerlendirmektir.Hastalar ve Metod: Habitual horlaması olan çocuklara polisomnografi yapıldı. Uyku çalışmasını takip eden sabah 08.00-09.00 saatleri arasında açlık venöz kan alındı. Apne-hipopne indeksi >= 5/saat olan çocuklar orta-ciddi OUAS, < 5/saat olan çocuklar hafif OUAS/primer horlama grubuna alındı.Bulgular: Çalışmaya 47 çocuk (%51 erkek ve %49 kız; yaş ortalaması 7.8 ± 2.6 yıl) alındı. Yirmi yedi çocuk orta-ciddi OUAS, hafif OUAS/primer horlama grubunda yer aldı. İki grup arasında yaş, cinsiyet ve vücut kitle indeksi açısından anlamlı fark yoktu (p> 0.05). Log serum leptin seviyeleri gruplar arasında farklı değildi (p= 0.749). Çalışma grubunun tümünde log leptin seviyeleri BMI z skoru ile pozitif korelasyon gösterdi (p= 0.001; r= 0.499), fakat log leptin seviyeleri apne-hipopne indeksi, ortalama ve en düşük oksijen satürasyonu ile korelasyon göstermedi.Sonuç: Habitual horlaması olan çocuklarda serum leptin seviyeleri yağ dokusundan etkilenmektedir fakat OUAS şiddetinden etkilenmemektedir.

Leptin levels in children with obstructive sleep apnea syndrome

Introduction: The aim of this study is to assess the effect of obstructive sleep apnea syndrome (OSAS) severity on leptin levels in children. Patients and Methods: Children with habitual snoring underwent overnight polysomnography. Fasting venous blood samples were obtained between 8 AM and 9 AM, following the night of the sleep study. Children with an apnea-hypopnea index of >= 5/h were included in the moderate-to-severe OSAS group while those with an apnea-hypopnea index of < 5/h formed the mild OSAS/primary snoring group.Results: 47 children (51% male and 49% female; mean age 7.8 ± 2.6 years) were recruited. Twenty seven participants were diagnosed with moderate-to-severe OSAS, and twenty children who had AHI < 5 were included in the mild OSAS/primary snoring. The two groups did not differ regarding age, gender and body mass index z score (p> 0.05). Furthermore there were no differences in log serum leptin levels (p= 0.749). Log serum leptin levels correlated with the BMI z score in the whole study group (p= 0.001; r= 0.499) but they were not associated with apnea-hypopnea index, mean and lowest oxygen saturation during sleep.Conclusion: Serum leptin levels are affected by adiposity but not by OSAS severity among children with habitual snoring.

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