Sema USLU, Muzaffer METİNTAŞ, Sinan ERGİNEL, İrfan UÇGUN, Özkan ALATAŞ, Füsun ALATAŞ, Hale MORAL

Akciğer tüberkülozunda serum adenozin deaminaz aktivitesi

Tüberküloz (Tbc) plörezide adenozin deaminaz (ADA) aktivitesi, tanıda yardımcı olmaktadır. Ancak akciğer Tbc'sinin tanısında ve takibinde serum ADA aktiv'ıteleri hakkında sınırlı çalışma bulunmakladır. Çalışmamızda, akciğer Tbc'sinin tanısındaki yeri ve tedavi etkinliğinin gösterilmesindeki rolünün araştırılması amacıyla serum ADA aktioiteleri değerlendirildi. Akciğer Tbc'li (n= 44) olgularda serum ADA aktivitesi (ortalama ± SD) 21.77 ± 8.51 U/L, tedavi ile iyileşmiş Tbc sekelli olgularda (n= 24) 6.24 ± 3.25 U/L, sağlıklı kontrol olgularında (n= 20) 8.58 ± 4.38 U/L ve bronş kanserli olgularda (n= 20) 18.51 ± 7.85 U/L olarak saptandı. Akciğer Tbc'li olguların sonuçları ile bronş kanserli olguların sonuçları arasında istatistiksel olarak farklılık yoktu. Buna karşılık, her iki grup ile tedavi ile iyileşmiş Tbc sekelli ve sağlıklı kontrol olguları arasında istatistiksel olarak anlamlı farklılık mevcuttu (p< 0.001). Tedavi öncesi ve sonrası serum ADA aktiviteleri ölçülebilen 10 akciğer Tbc'li olgunun serum ADA aktivitelerinde tedavi sonrası belirgin düşme saptandı (p< 0.001). Sonuç olarak, akciğer Tbc'li olgular serum ADA aktivitesinin arttığını ve tedavinin izleminde yararlı bir parametre olabileceğini düşünüyoruz.

Serum adenosine deaminase activity in pulmonary tuberculosis

Adenosine deaminase (ADA) activity has been helpful for the diagnosis of tuberculous pleurisy. However, there are few studies about the role of ADA in the diagnosis and follow-up of pulmonary tuberculosis. In our study, serum ADA activity was determined in order to investigate the role of the enzyme in the diagnosis of pulmonary tuberculosis and monitoring the efficiency of therapy. The ADA activity was (mean ± SD) 21.77 ± 8.51 U/L in pulmonary tuberculosis patients (n= 44), 6.24 ± 3.25 U/L in old tuberculosis patients (n= 24), 8.58 ± 4.38 U/L in healthy control subjects (n= 20), whereas the mean for the patients with bronchial cancer (n= 20) was 18.51 ± 7.85 U/L. There was no statistical difference between the results of pulmonary tuberculosis patients and the patients with bronchial cancer. On the contrary, the result of these two group were significantly different from both old tuberculosis patients and healthy control subjects (p< 0.001 for both). In 10 pulmonary tuberculosis patients, ADA activities were determined both before and after treatment and a significant decrease was observed in ADA activities after treatment (p< 0.001). In conclusion, serum ADA activity is increased in pulmonary tuberculosis patients, therefore it may be a helpful parameter for monitoring therapy.

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