Kalp damar hastalıkları ve çevresel faktörler

Epidemiyolojik ve klinik birçok çalışma sadece majör risk faktörleri ve genetik faktörlerin değil aynı zamanda çevresel faktörlerin de kalp damar hastalıklarının oluşmasında etkisi olduğunu göstermektedir. Çevresel faktörler kalp damar hastalıklarının temel belirleyicilerindendir. Sigara içme, diyet alışkanlığı ve fiziksel egzersiz alışkanlığı gibi majör faktörler yaygın bir şekilde bilindiği halde kimyasal kirlilik gibi diğer çevresel faktörlerin etkisi daha az bilinmektedir. Ancak çevredeki fiziksel ve kimyasal kirlilik etkenlerine maruz kalmanın kalp damar hastalığının riskini artırdığı bilinmektedir. Çevresel faktörler ile koroner arter hastalığı, kardiyomiyopati ve aritmiler arasında ilişki olduğu birçok çalışmada bulunmuştur. Arsenik, kurşun, kadmiyum, değişik kirletici gazlar ve solventler, pestisitler kalp damar hastalıkları ile ilişkili çevresel kimyasalların başlıcalarıdır. Bu yazıda kalp damar hastalıkları ile fiziksel, kimyasal, biyolojik ve sosyokültürel çevresel faktörler arasındaki ilişkiler incelenecektir.

Environmental factors and cardiovascular diseases

Epidemiological and clinical observations have led to the hypothesis that the risk of developing cardiovascular diseases is influenced not only by genetic, lifestyle and major risk factors, but also by environmental factors. Environmental factors are considered key determinants of cardiovascular diseases. Although lifestyle choices such as smoking, diet, and exercise are viewed as major environmental influences, the contribution of pollutants and environmental chemicals is less clear. Accumulating evidence suggests that exposure to physically and chemical pollutants could elevate the risk of cardiovascular diseases. Many epidemiological studies report that exposure to physically, biologically and socio-cultural environmental factors are associated with an increase in cardiovascular mortality. Relationships between environmental factors and coronary arter disease, arhythmias, and cardiomyopathies have been reported. Exposures to arsenic, lead, cadmium, pollutant gases, solvents, and pesticides have also been linked to increased incidence of cardiovascular disease. In this paper, I review that relationships between exposure to physically, chemical, biologically and socio-cultural environmental factors and cardiovascular diseases.

___

  • 1. Acute coronary heart disease mortality, morbidity, and medical care from 1985 through 1997: the Minnesota heart survey. Circulation. 2001;104(1): 19-24.
  • 2. Malach M, Imperato PJ. Acute myocardial infarction and acute coronary syndrome: then and now (1950-2005). Prev Cardiol. 2006; 9(4): 228-34. Review.
  • 3. Whitfield MD, Gillett M, Holmes M, Ogden E. Predicting the impact of population level risk reduction in cardio-vascular disease and stroke on acute hospital admission rates over a 5 year period--a pilot study. Public Health. 2006;120(12): 1140-8.
  • 4. Benowitz NL. Cardiovascular toxicology. Ch.21. p.334. in “Current Occupational and Environmental Medicine” Ed.:Ladou J. Fourth Edition. Mc Graw Hill Medical, 2004.
  • 5. Fuster V, Gotto AMJ. Risk Reduction. Circulation 2000; 102: IV-94.
  • 6. Olden K, White SL. Health-related disparities: influence of environmental factors. Med Clin North Am. 2005; 89(4): 721-38.
  • 7. Little MP, Tawn EJ, Tzoulaki I, Wakeford R, Hildebrandt G, Paris F, Tapio S, Elliott P. A systematic review of epidemiological associations between low and moderate doses of ionizing radiation and late cardiovascular effects, and their possible mechanisms. Radiat Res. 2008; 169(1):99-109.
  • 8. McGale P, Darby SC. Low doses of ionizing radiation and circulatory diseases: a systematic review of the published epidemiological evidence. Radiat Res. 2005 Mar;163(3):247-57. Erratum in: Radiat Res. 2005; 163(6): 711.
  • 9. Holick MF. Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need? Adv Exp Med Biol. 2008;624:1-15.
  • 10. Ahlbom IC, Cardis E, Green A, Linet M, Savitz D, Swerdlow A; ICNIRP (International Commission for Non-Ionizing Radiation Protection) Standing Committee on Epidemiology Review of the epidemiologic literature on EMF and Health. Environ Health Perspect. 200; 109(6): 911-33.
  • 11. Johansen C. Electromagnetic fields and health effects--epidemiologic studies of cancer, diseases of the central nervous system and arrhythmiarelated heart disease.Scand J Work Environ Health. 2004; 30(1): 1-30.
  • 12. Habash RW, Brodsky LM, Leiss W, Krewski D, Repacholi M. Health risks of electromagnetic fields. Part I: Evaluation and assessment of electric and magnetic fields. Crit Rev Biomed Eng. 2003; 31(3): 141-95.
  • 13. Ahlbom A, Green A, Kheifets L, Savitz D, Swerdlow A. ICNIRP (International Commission for Non-Ionizing Radiation Protection) Standing Committee on Epidemiology. Epidemiology of health effects of radiofrequency exposure. Environ Health Perspect. 2004; 112(17): 1741-54.
  • 14. Jarup L, Babisch W, Houthuijs D, Pershagen G, Katsouyanni K, Cadum E, Dudley ML, Savigny P, Seiffert I, Swart W, Breugelmans O, Bluhm G, Selander J, Haralabidis A, Dimakopoulou K, Sourtzi P, Velonakis M, Vigna-Taglianti F; HYENA study team. Hypertension and Exposure to Noise near Airports: the HYENA study. Environ Health Perspect. 2008; 116(3): 329-33
  • 15. Willich SN, Wegscheider K, Stallmann M, Keil T. Noise burden and the risk of myocardial infarction. Eur Heart J. 2006; 27(3): 276-82.
  • 16. Ishigami A, Hajat S, Kovats RS, Bisanti L, Rognoni M, Russo A, Paldy A. An ecological time-series study of heat-related mortality in three European cities. Environ Health. 200; 7: 5.
  • 17. Rosenman KD. Disorders of Heart and Blood Vessels. Ch.17. p.295. in “Fundamentals of Environmental Medicine” Ed. : Tarcher AB. Principles and Practice of Environmental Medicine, New York. Plenum Medical Book Company, 1992.
  • 18. Fuster V, Alexander W, O’Rourke R. The Heart, 10th edition. McGraw and Hill, 2001.
  • 19. Bleys J, Navas-Acien A, Guallar E. Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults. Arch Intern Med. 200; 168(4): 404-10.
  • 20. Navas-Acien A, Bleys J, Guallar E. Selenium intake and cardiovascular risk: what is new? Curr Opin Lipidol. 2008 Feb;19(1):43-9.
  • 21. Cunningham SR, Dalzell GW, McGirr P, Khan MM. Myocardial infarction and primary ventricular fibrillation after glue sniffing. Br Med J (Clin Res Ed). 1987; 294(6574): 739-40.
  • 22. Wu MM, Kuo TL, Hwang YH, Chen CJ. Doseresponse relation between arsenic concentration in well water and mortality from cancers and vascular diseases. Am J Epidemiol. 1989; 130(6):1123-32.
  • 23. Egeland GM, Bloom TF, Schnorr TM, Hornung RW, Suruda AJ, Wille KK. Fluorocarbon 113 exposure and cardiac dysrhythmias among aerospace workers. Am J Ind Med. 1992;22(6):851-7.
  • 24. Antti-Poika M, Heikkilä J, Saarinen L. Cardiac arrhythmias during occupational exposure to fluorinated hydrocarbons. Br J Ind Med. 1990; 7(2): 138-40.
  • 25. Soden KJ, Marras G, Amsel J. Carboxyhemoglobin levels in methylene chlorideexposed employees. J Occup Environ Med. 1996 Apr;38(4):367-71.
  • 26. Klatsky AL. Alcohol and cardiovascular diseases: a historical overview. Ann N Y Acad Sci. 2002;57: 7-15. Review.
  • 27. Steenland K, Piacitelli L, Deddens J, Fingerhut M, Chang LI. Cancer, heart disease, and diabetes in workers exposed to 2,3,7,8-tetrachlorodibenzo-pdioxin. J Natl Cancer Inst. 1999; 91(9): 779-86.
  • 28. Mahaffey KR, Rice G, et al. An Assessment of Exposure to Mercury in the United States: Mercury Study Report to Congress. Washington, DC: U.S. Environmental Protections Agency; 1997. Document EPA-452/R097-006.
  • 29. Oka T, Matsukura M, Okamoto M, Harada N, Kitano T, Miike T, Futatsuka M. Autonomic nervous functions in fetal type Minamata disease patients: assessment of heart rate variability. Tohoku J Exp Med. 2002; 198(4): 215-21.
  • 30. Futatsuka M, Kitano T, Shono M, Nagano M, Wakamiya J, Miyamoto K, Ushijima K, Inaoka T, Fukuda Y, Nakagawa M, Arimura K, Osame M. Long-term follow-up study of health status in population living in methylmercury-polluted area. Environ Sci. 2005;12(5): 239-82.
  • 31. Bahçebaşı T. Minamata Hastalığı. 2. Çevre Hekimliği Kongresi. Özet kitabı. Ankara. 2006, p.185.
  • 32. Bakir F, Damlugi SF, Amin-Zaki L, et al. Methylmercury poisoning in Iraq. Science. 1973;181: 230-41.
  • 33. Evrensel T. Kimyasal tarım ilaçlarına Dikkat. Buğday Dergisi Sayı: 12, 2007 http://www.bugday.org/article.php?ID=1637 [Erişim tarihi 4.3.2008]
  • 34. Bhatnagar A. Environmental cardiology: studying mechanistic links between pollution and heart disease. Circ Res. 2006; 99(7): 692-705. Review.
  • 35. Trewavas A, Stewart D. Paradoxical effects of chemicals in the diet on health. Curr Opin Plant Biol. 2003 Apr;6(2):185-90. Review.
  • 36. Netterstrøm B, Juel K. Impact of work-related and psychosocial factors on the development of ischemic heart disease among urban bus drivers in Denmark. Scand J Work Environ Health. 1988;14(4): 231-8.
  • 37. Marmot M, Shipley M, Brunner E, Hemingway H. Relative contribution of early life and adult socioeconomic factors to adult morbidity in the Whitehall II study. J Epidemiol Community Health. 2001; 55(5): 301-7.
  • 38. Catling LA, Abubakar I, Swift L, Hunter PR, Lake IR. A systematic review of analytical observational studies investigating the association between cardiovascular disease and drinking water hardness. J Water Health. 2008;6(4): 433-442.
  • 39. Monarca S, Donato F, Zerbini I, Calderon RL, Craun GF. Review of epidemiological studies on drinking water hardness and cardiovascular diseases. Eur J Cardiovasc Prev Rehabil. 2006;13(4): 495- 506.
  • 40. Tekbaş ÖF, Güleç M. Suların Sertlik Dereceleri Ve Sağlık Etkileri. TSK Koruyucu Hekimlik Bülteni, 2004: 3(7).
  • 41. Lawrence JF, Rosenstock L. Cardiovascular Disorders. Ch.24. p.549. in “Textbook of Clinical Occupational and Environmental Medicine” Vol:1. Eds.: Rosenstock L., Cullen M., Brodkin CA., Redlich CA. Second Edition. Elsevier Saunders,2005.
  • 42. Prozialeck WC, Edwards JR, Nebert DW, Woods JM, Barchowsky A, Atchison WD. The vascular system as a target of metal toxicity. Toxicol Sci. 2008; 102(2): 207-18.
  • 43. Mathews I, Parry S. The Burden Of Disease Attributable To Environmental Pollution, University of Wales College of Medicine. Cardiff University. The views presented in this paper are those of the authors and do not necessarily. Represent HPA views. 2005.
  • 44. Seghizzi P, D'Adda F, Borleri D, Barbic F, Mosconi G. Cobalt myocardiopathy. A critical review of literature. Sci Total Environ. 1994; 150(1-3): 105-9. Review
  • 45. Gariano JM, Manson JE, Ridker PM. Primary and secondary prevention of coronary heart disease. In: Zipes DP, Libby P, Bonow RO, Braunwald E: Braunwald’s Heart Disease. 7th ed. Philadephia, Elsevier-Saunders, 2005, p. 1057-1084.