ERİTROSİTLERDE in vitro OKSİDATİF STRESE KARŞI ANTİOKSİDAN OLARAK DEĞERLENDİRİLEN ÇEŞİTLİ BİTKİ EKSTRAKTLARI

Son yıllarda pek çok hastalığın patogenezinde oksidatif stresin etken olması araştırıcıların dikkatini çekmiştir. Eritrositler tüm vücut dokuları ve organları ile iletişim halinde olan, oksidatif strese karşı en hassas hücre gruplarından biridir. Bu nedenle oksidatif stresin olumsuz etkilerinin belirlenmesi için yapılan çalışmalarda eritrosit hücreleri sıklıkla kullanılmaktadır. Bununla birlikte oksidatif stresin olumsuz etkilerinin azaltılabilmesi veya yok edilebilmesi için doğal kaynaklı antioksidan maddelerin arayışı ile ilgili çalışma sayısı her geçen gün artmaktadır. Bu doğal kaynaklı antioksidan maddelerin tespiti için yapılan çalışmalarda çoğunlukla bitki ekstraktlarından yararlanılmakta ve bu ekstraktların antioksidan kapasiteleri araştırılmaktadır. Bu çalışmada, eritrositlerde oksidatif stresin meydana getirilme yolları ve oksidatif strese karşı kullanılan bitki ekstraktları ile ilgili bilgilere yer verilmiştir.

Anahtar Kelimeler:

Bitki ekstraktı, oksidatif stres, eritrosit, in vitro

Various Plant Extracts Evaulated as Antioxidant Against in vitro Oxidative Stress in Erythrocytes

The role of oxidative stress in pathogenesis of many diseases has interested researchers in recent years. Erythrocytes are in contact with all organs and tissues and are one of the most vulnerable cell types against oxidative stress. Therefore, erythrocyte cells are commonly used in studies performed to reveal negative effects of oxidative stress. On the other hand, the number of studies carried out with the aim of finding natural antioxidants to reduce or neutralize negative effects of oxidative stress is increasing day by day. Plant extracts are mostly used in these studies and antioxidant effects of these extracts are investigated. In the present study, current data on the means of producing oxidative stress in erythrocytes and the plant extracts used against oxidative stress were reviewed.

Keywords:

Plant extract, oxidative stress, erythrocyte, in vitro,

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