NURETTİN AYDOĞDU, HAKAN ERBAŞ, Kadir KAYMAK

Taurin, melatonin ve N-asetilsisteinin kadmiyuma bağlı akciğer hasarındaki antioksidan etkileri

Amaç: Antioksidan özelliği bilinen taurin, melatonin ve N-asetilsisteinin (NAC) kadmiyum klorüre (CdCl2) bağlı olarak gelişen akciğer hasarını önlemedeki ve oluşmuş hasarı tedavi etmedeki etkinlikleri karşılaştırıldı. Çalışma Planı: Çalışmamızda 90 adet erkek Sprague-Dawley cinsi sıçan dokuz gruba ayrıldı. Üç ay süreyle grup 1'e içme suyu, grup 2'ye 200 ppm CdCl2, grup 3'e 200 ppm CdCl2 ve %1 taurin, grup 4'e 200 ppm CdCl2 ve %0.02 melatonin, grup 5'e 200 ppm CdCl2 ve %0.5 NAC içme sularına katıldı. Grup 6, 7, 8 ve 9'un içme sularına üç ay süreyle 200 ppm CdCl2 katıldıktan sonra; yedi gün süreyle 6. gruba içme suyu, 7. gruba %4 taurin, 8. gruba %0.08 melatonin ve 9. gruba %2 NAC içme sularına katılarak verildi. Bulgular: Koruyucu amaçla verilen melatonin ve NAC'nin azalmış glutatyon düzeyini artırdığı, hem koruyucu hem de tedavi amaçlı verilen üç ajanın da artmış olan lipit peroksidasyonun son ürünlerinden biri olan malondialdehit düzeylerini azalttığı görüldü. Sonuç: Taurin, melatonin ve NAC CdCl2'e bağlı olarak gelişen akciğer hasarına karşı hem koruyucu hem de tedavi edici rol oynamaktadır.

Anahtar Kelimeler:

Modeller, hayvan, Taurin, Asetilsistein, Melatonin, Glutatyon, Antioksidanlar, Kadmiyum, Sıçan, Sprague-Dawley, Akciğer hasarı

The antioxidant effects of taurine, melatonin and N-acetylcysteine in cadmium-induced lung injury

Objectives: The potential protective and therapeutic effects of taurine, melatonin and N-acetylcysteine (NAC), which are recognized as antioxidant agents, in cadmium chloride (CdCl2)-induced lung injury were compared. Study Design: Ninety male Sprague-Dawley rats were divided into 9 groups. During the 3 months treatment period, group 1 received drinking water, group 2 200 ppm CdCl2, group 3 200 ppm CdCl2 and 1% taurine, to, group 4, 200 ppm CdCl2 and 0.02% melatonin, and group 5 received 200 ppm CdCl2 and 0.5% NAC all added into drinking water in each group. After, groups 6, 7, 8 and 9 received 200 ppm CdCl2 in their drinking water for 3 months, group 6 was given drinking water, group 7, 4% taurine, group 8, 0.08% melatonin and group 9, 2% NAC, each for 7 days. Results: Melatonin and NAC which were given for protective purposes, increased the decreased glutathione levels. The 3 substances that were administered for both protective and therapeutic purposes, decreased the increased malondialdehyde levels, one of the end products of lipid peroxidation. Conclusion: Taurine, melatonin and NAC play protective and therapeutic roles in CdCl2 induced lung injury.

Keywords:

Models, Animal, Taurine, Acetylcysteine, Melatonin, Glutathione, Antioxidants, Cadmium, Rats, Sprague-Dawley, Lung Injury,

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