High C-reactive protein and amylase levels as prognostic markers in non-pancreatic severe sepsis patients

Amaç: Kritik hastalarda sepsis ilerleyen multi organ yetmezliği ile ilişkilidir. Ağır sepsiste ilave biyogöstergeler, yüksek riskli hastaların etkili tedavi seçiminde ve prognozun belirlenmesi mücadelesinde başarılı olmak için gereklidir. Bu araştırmada ağır sepsisli hastalarda sağkalım için belirleyici faktörler olarak serumda C-reaktif protein (CRP) ve amilaz değerlendirildi. Hastalar ve Yöntemler: Çalışmaya ağır sepsis kriterlerini sağlayan 95 hasta (42 erkek, 53 kadın) dahil edildi. APACHE II skorları, serum CRP ve amilaz düzeyleri hastaların yoğun bakım ünitesine kabul edildiğinde, iki gün sonra ve yoğun bakım ünitesinden taburcu edildiği gün veya kaybedildikleri gün alındı. Bulgular: Amilaz ve ortalama CRP düzeyleri ile APACHE II skorları yaşamını kaybeden hastalarda, sağ kalan hastalardan anlamlı derecede yüksekti. Sonuç: Serum amilaz ve CRP, ağır sepsisli hastalarda sağkalımı belirleyicidir. Yüksek amilaz ve CRP düzeyleri ağır sepsisli hastaların risk değerlendirmesinde ve gelecek çalışmalarda yüksek riskli hastaların sınıflandırılmasında değerli araçlar olarak görülebilir.

Anahtar Kelimeler:

Seyir, C-reaktif protein, Hastalık ciddiyet indeksi, Amilazlar, Sepsis, APACHE

Pankreatik olmayan ağır sepsisli hastalarda belirleyici faktörler olarak yüksek C-reaktif protein ve amilaz değerleri

Objectives: Sepsis in critical illness is associated with the progressive failure of multiple organs. Additional biomarkers in severe sepsis are needed to tackle the challenges of determining a prognosis and optimizing the selection of high-risk patients for therapy. This paper evaluates serum C-reactive protein (CRP) and amylase as prognostic factors for survival in patients with severe sepsis. Patients and Methods: Ninety-five patients (42 males, 53 females) meeting the criteria for severe sepsis were chosen for the study. APACHE II scores, serum levels of CRP and amylase were taken on admission to an intensive care unit, two days later, and on the day of discharge from the intensive care unit or on the day of death. Results: Amylase levels, median CRP levels, and APACHE II scores were significantly higher in the non-survivors than in the surviving patients. Conclusion: Serum amylase and CRP are predictors of survival in patients with severe sepsis. High amylase and CRP levels appear to be a valuable tool for individual risk assessment in severe sepsis patients and for stratification of high-risk patients in future intervention trials.

Keywords:

Prognosis, C-Reactive Protein, Severity of Illness Index, Amylases, Sepsis, APACHE,

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