Babürhan GÜLDİKEN, Hülya ÖZKAN, Levent KARAYEL

Akut iskemik inmede ortalama trombosit hacmi ve periferik kan hücre sayısı yanıtı

Amaç: Ortalama trombosit hacminin (OTH) trombosit aktivitesinin iyi bir göstergesi olduğu, vasküler hastalıklarda arttığı bildirilmektedir. Bu çalışmada akut iskemik inmede, inme alttipleri ile OTH'nin ilişkisinin araştırılması amaçlandı. Hastalar ve Yöntemler: Çalışmada ORG 10172 çalışması TOAST kriterlerine göre büyük (n=43) ve küçük (n=59) damar hastalığı olarak alttiplendirmesi yapılan, akut iskemik inme geçiren 102 hastanın OTH değerleri, yaş ve cinsiyet eşleştirilmiş 48 sağlıklı birey ile karşılaştırıldı. Ortalama trombosit hacminin inme alttipleri, inme şiddeti ve diğer hematolojik parametreler (trombosit sayısı, platekrit, hemoglobin, hematokrit, eritsosit sayısı, ortalama korpusküler hacim, lökosit, nötrofil, lenfosit, monosit sayıları) ile ilişkisi araştırıldı. Bulgular: İnme altgrupları ve kontrol grubu arasında OTH değerleri açısından fark tespit edilmezken, OTH ile inme şiddeti ve diğer hematolojik parametreler arasında da ilişki saptanmadı (p>0.05). Büyük damar hastalığı olanlarda, küçük damar hastalığı olanlara ve kontrollere göre lökosit ve nötrofil sayısında artışın anlamlı olarak daha fazla olduğu görüldü (p

Anahtar Kelimeler:

Nötrofiller, Eritrosit indeksleri, İnme, Geriyedönük çalışma, Trombosit sayısı, Lökositler, İskemi

Mean platelet volume and peripheral blood count response in acute ischemic stroke

Objectives: Mean platelet volume (MPV) is a marker of the platelet activity and is reported to increase in vascular diseases. The aim of the study is to investigate the relationship between MPV and the subtypes of acute ischemic stroke. Patients and Methods: The patient group consisted of 102 acute ischemic stroke patients who were divided into the large vessel (n=43) and the small vessel (n=59) disease subgroups. Their MPV values were compared with those of 48 age/sex-matched healthy individuals. The relationship of MPV with the subtypes and severity of stroke, and other hematological parameters (platelet count, platecrit, hemoglobin, hematocrit, erythrocyte count, mean corpuscular volume, leukocyte, neutrophil, lymphocyte, monocyte) was further investigated. Results: No difference was found in terms of MPV values between the patient subgroups and control group, and no relation was found between MPV and stroke severity and other hematological parameters (p>0.05). A significant increase in the leukocyte and neutrophil count was seen in patients of the large vessel disease group when compared with the small vessel disease and control group (p<0.005). Neutrophil count is found to be a risk factor for the stroke severity (β=0.362, p=0.01, OR=1.437, CI %95 0.02-0.08). Conclusion: No significant change in MPV was seen in acute ischemic stroke. High leukocyte and neutrophil levels are markers for the large vessel disease subtype and severity of ischemic stroke.

Keywords:

Neutrophils, Erythrocyte Indices, Stroke, Retrospective Studies, Platelet Count, Leukocytes, Ischemia,

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